According to scientific information, almost every second inhabitant of our planet is hypertonic. Those who suffer from high blood pressure need therapy with antihypertensive drugs.
"Diovan" refers to drugs that are prescribed as antihypertensive drugs.
Structure
The medication is produced in tablet form. The active substance of "Diovan" is valsartan.
Tablets with a dosage of 40 milligrams have a yellow tint, oval shape, DO marking.
According to the instructions for use, "Diovan 80 mg" has a pink color, rounded shape, DV marking.
Tablets with a dose of 160 mg oval, gray in color, marked DX / DX.
Tablets with the amount of the active ingredient in 320 mg are purple, oval, and also marked DXL. The average price of "Diovan" varies from 1400 to 2000 rubles.
The following substances act as additional trace elements:
- hypromellose;
- titanium dioxide;
- magnesium stearate;
- silicon dioxide;
- macrogol 8000;
- crospovidone;
- cellulose;
- iron oxide yellow.
Pharmacological properties
When treating people with arterial hypertension, a decrease in blood pressure can be observed, which is not accompanied by a fluctuation in the heart rate.
According to the instructions for use with Diovan, tablets after a single dosage have an antihypertensive effect in the first hundred and twenty minutes, and the maximum concentration occurs after six hours. Efficiency after use persists for more than a day.
A sharp cessation of the use of the drug does not cause a sudden increase in blood pressure or other negative manifestations.
Clinical evidence confirms that the drug has no effect on the concentration of uric acid, cholesterol, triglycerides in blood plasma.
The main trace element of the drug in a small amount is stored in the body. The active component is excreted from the body with feces and urine.
Indications. How to take the drug?
The drug is recommended for use in the presence of the following conditions and ailments:
- Arterial hypertension.
- Chronic heart failure.
- Acute myocardial infarction.
The tablets must be used orally without chewing. To eliminate arterial hypertension, you need to use (according to instructions) "Diovana" 80 mg once a day for people of any age.
The drug shows efficacy fourteen days after the start of the course. The maximum effect of the drug is noticeable after about thirty days. If blood pressure does not drop to normal, then the dosage can be increased to 320 milligrams, or diuretics are prescribed.
From the instructions to Diovan, it is known that forty milligrams of the drug should be consumed twice a day to eliminate chronic heart failure. Gradually, the dose can be increased to eighty milligrams twice a day.
If the medication is well perceived, then its amount is increased to 320 milligrams per day. The concentration of diuretics that are used simultaneously will have to be reduced.
In chronic heart failure, kidney function must be monitored. After a myocardial infarction, therapy should begin in the first twelve hours. Initially prescribed twenty milligrams twice a day.
Then, after three months of therapy, gradually increase to 160 mg twice a day. The maximum daily dosage can reach 320 milligrams, which must be divided into two doses.
Overdose
According to the instructions to "Diovan", tablets with excessive excess doses can cause the following signs of poisoning:
- shock;
- collapse;
- a sharp decrease in blood pressure.
For overdose therapy, induce vomiting and take an absorbent.
Side effects
The use of "Diovan" can provoke the appearance of the following negative reactions:
- Thrombocytopenia (a condition characterized by a decrease in platelet count below the standard).
- Neutropenia (low level of neutrophilic granulocytes in the general cellular composition of the blood).
- Rhinitis (an infection that affects the mucous membrane of the nasal cavity and causes a violation of its functions).
- Feeling tired.
- Sinusitis (inflammation of the mucous membrane of one or more sinuses).
- Pharyngitis (acute or chronic inflammatory process localized in the pharynx, affecting its mucous membrane and deeper layers).
- Respiratory tract infections.
- Viral infections.
- Migraine (a neurological disease, the most frequent and characteristic symptom of which is episodic or regular severe pain).
- Dizziness.
- Lowering libido.
- Insomnia (a sleep disorder characterized by insufficient duration or poor sleep quality).
- Fainting.
- Vertigo (known as dizziness, it is characteristic of ear pathology or, less commonly, brain damage).
- Postural dizziness (repeated transient short-term bouts of systemic dizziness).
- Serum sickness (an immune response to the introduction of foreign serum proteins).
- Increased Sensitivity.
- Cough.
- Vasculitis (a group of diseases based on immunopathological inflammation of blood vessels - arteries, arterioles, capillaries, venules and veins).
- Heart failure.
- Arterial hypotension (lowering blood pressure by more than twenty percent of the standard).
- Orthostatic hypotension (a clinical syndrome characterized by a violation of the body's ability to maintain a normal level of blood pressure when a person is standing up or standing for a long time).
- Angioneurotic edema (an acute condition characterized by the rapid development of local edema of the mucous membrane, subcutaneous tissue and the skin itself).
- Diarrhea.
- Renal failure.
- Myalgia (a disease that is characterized by pain in the muscles of various nature).
- Arthralgia (joint pains that are volatile in the absence of objective symptoms of joint damage).
- Hyperkalemia (a pathological condition that causes an abnormally high concentration of potassium in the blood).
- Asthenia (asthenic state, asthenic syndrome, asthenic reaction, neuropsychic weakness, chronic fatigue syndrome).
- Feeling tired.
Contraindications
The drug is not recommended for use in the presence of the following ailments:
- High sensitivity to the drug.
- Lactation.
- Pregnancy.
At the same time, it is important to be especially careful when taking Diovan for diseases of the kidneys and liver, as well as for a diet with a low sodium content.
Can I use "Diovan" during pregnancy and lactation?
When using the drug in the second and third trimester of "interesting position" there is a risk of fetal death. If you use "Diovan" in the first three months of pregnancy, the likelihood of birth defects in the child increases.
There is evidence of impaired renal function in newborns and spontaneous abortions in expectant mothers who used valsartan.
Pregnant women and girls who plan to become pregnant should not use this medication.
The drug should not be used for lactation, since the active substance is excreted in milk.
Drug interaction
The drug after oral administration is not exposed to significant metabolism, therefore there is no risk of its harmful interaction with other medicines.
The simultaneous use of potassium-containing diuretics, as well as salts with potassium, can provoke an increase in potassium in the blood. With such complex therapy, caution must be exercised.
Features
In the treatment of patients who suffer from essential arterial hypertension, it is not necessary to periodically monitor the indicators.
In people with a sodium deficiency in the body, sometimes at the beginning of the course, blood pressure may decrease and symptoms of arterial hypotension may manifest.
If this disease occurs, the patient should be laid with raised legs, then 0.9% sodium chloride solution should be administered intravenously. After normalizing blood pressure, treatment with the drug can be continued.
In patients with renovascular hypertension, which appeared after renal artery stenosis, renal hemodynamics, as well as the number of plasma creatinine and urea nitrogen, do not change after the course.
Patients who have impaired renal function may not need to adjust the dose of Diovan. With significant lesions, therapy should be carried out with extreme caution.
People suffering from kidney disease do not have to make adjustments to exclude cholestasis. The main active substance is excreted from the body in the form of bile. When taking the course of therapy with the drug "Diovan" you also need to be careful.
People who have had a myocardial infarction or chronic heart failure using this medicine have noticed a slight decrease in blood pressure. Therefore, it should be at the beginning of treatment to monitor indicators. If you follow all the recommendations, then stop taking "Diovan" is not necessary.
For patients using beta blockers and valsartan in parallel, caution is essential.
According to the reviews and instructions for use for "Diovan", it is known that when completing the course it is important to be especially careful when driving a car and when working with complex mechanisms.
To eliminate arterial hypertension and chronic heart failure, the drug "Diovan" can be prescribed as monotherapy or together with other medicines that lower blood pressure. At the same time, diuretics, digitalis preparations or angiotensin - converting enzyme inhibitors are prescribed .
In treatment with Diovan, statins, acetylsalicylic acid and thrombolytics can be used.
The use of valsartan by children under eighteen years of age is poorly understood. Since there is no reliable information about the safety and effectiveness of this drug in this category of patients, it is therefore not recommended to use it (according to the instructions for use).
Analogs
"Diovan" has substitutes for therapeutic effects, for example:
- "Tareg".
- Tantordio
- Nortian.
- "Valsacor".
- Valsafors.
- "Valsasin".
- "Valsartan".
- Valz.
- "Valaar."
- "Artinova."
Storage conditions
The drug "Diovan" is recommended to be kept at a temperature not exceeding thirty degrees, in a dry place, inaccessible to children. Shelf life is thirty-six months. The drug is dispensed from pharmacy points strictly according to the prescription (according to the instructions).
Diovan: reviews
People with arterial hypertension leave positive feedback about the medication. They tell about the improvement of the general condition both with monotherapy and with its combination with other antihypertensive drugs.
It happens that at the beginning of the course side effects occur, which are most often expressed in nausea and dizziness.
Since the drug is not suitable for everyone, the doctor should individually select the therapy for arterial hypertension. Medical experts speak well of Diovan as an effective drug for the treatment of chronic heart failure and advise it to be used in rehabilitation after myocardial infarction.
If the patient adheres to the prescribed treatment regimen, the use of "Diovan" gives a positive result and is not accompanied by negative effects.