“Cefix” is a suspension (instructions for children are included with the product), the active substance of which is 3rd generation cephalosporin. This antibiotic effectively cures not only respiratory diseases, but also other infectious diseases. The medicine is also available in capsule form.
Composition and form of release
"Cefix" (instructions, use, composition of this drug indicate its effective effect on the children's body with colds, SARS, tonsillitis, influenza, etc.) contains the active substance cefixime trihydrate. 5 milliliters of suspension accounts for 100 mg of the active ingredient. Additional ingredients are croscarmellose sodium, sodium carboxymethyl cellulose, xanthan gum, microcrystalline cellulose, sodium benzoate, citric acid monohydrate, flavoring, sucrose.
The auxiliary components of the capsules are magnesium stearate, sodium lauryl sulfate, hydrogenated vegetable oil, croscarmellose sodium, microcrystalline cellulose.
The suspension for oral administration is available in a dosage of 100 mg / 5 ml in a 30 ml bottle and 100 mg / 5 ml in a 60 ml bottle. Capsules contain 200 and 400 mg of active substance.
The prepared suspension should be stored in a cool place for no more than fourteen days. The drug in the form of capsules is stored at a temperature not exceeding +25 ° C. The shelf life of undiluted suspension and capsules is about three years.
Pharmacology of the drug
"Cefix" is a suspension (instructions for children fully describes the proper use of the drug), which is highly stable to the presence of beta-lactamases - enzymes that are aimed at combating beta-lactam antibiotics. As a result, penicillin and cephalosporin-resistant organisms may be susceptible to the effects of the active substance of this drug.
"Cefix" is a broad-spectrum antibiotic and affects most strains of microorganisms, among which stand out:
- Gram-positive - this is pneumococcus, pyrrolidonyl peptidase, Streptococcus.
- Gram-negative, such as Proteus Mirabilis, hemophilic infections, Moraxella (Branhamella) catarrhalis, E. coli, gonococcus.
Cefix is instantly absorbed in the gastrointestinal tract. The speed of this process is not affected by food intake. Bioavailability for adults and children is about 30-50%. The highest concentration of the active substance is achieved 2-6 hours after taking the drug inside, regardless of its form of release. About half the dose taken during the day is excreted in the urine unchanged. Part of cefixime trihydrate leaves with bile.
With moderate renal impairment, 50% of the active substance leaves the human body for up to 6.4 hours. In severe renal failure, the half-life is 11.5 hours.
Indications for use
"Cefix" is a suspension (the instructions for children do not recommend using it without consulting a doctor), which is often prescribed for various infectious diseases of the urinary tract. An indication for use is an acute form of bowel disease. An antibiotic is prescribed for the treatment of a number of diseases caused by pneumococci and streptococci pyrrolidonyl peptidase. The medicine is used for ENT diseases, such as pharyngitis, tonsillitis, otitis media and sinusitis. It is used for various forms of bronchitis, acute pneumonia and other infectious diseases of the respiratory tract.
Contraindications
The drug “Cefix” (suspension) is completely contraindicated for people who are allergic to cephalosporin antibiotics. Instructions for children (reviews of some women note that improvement after taking the medicine occurs on the 2-3rd day of its use) up to twelve years, the drug is prohibited in capsules. For the treatment of children from six months to twelve years, a suspension should be used. You can not take the drug to pregnant and lactating women, if only the expected positive effect for the mother is several times higher than the risk of developing fetal pathology, then the doctor allows the use.
"Cefix": instructions for use for children
Suspension, unlike pills, is approved for use by young children. It is drunk after fifteen minutes after eating.
For children of the age category from twelve years of age and adults, the maximum daily norm of the drug is 400 mg. The duration of admission is controlled by the doctor. This period depends on the age and severity of the disease. For patients with creatinine clearance of 21 and 60 ml / min, the consumption rate is reduced to 300 mg per day. For patients with creatinine clearance less than 20 ml / min, the dose is reduced to 200 mg per day.
Children from six months to twelve years of age are prescribed another form of Cefix - suspension. Instructions for children on how to breed the powder yourself, tells in detail. To do this, take 30-35 ml of boiled water not lower than +25 ° C and pour the liquid into a vial of powder, close and thoroughly shake all the contents. After this process, the bottle is opened and water is added to risks. After that, the lid is screwed again, and the components are thoroughly mixed.
You can drink "Cefix" both before meals and after. If the antibiotic caused irritation of the gastrointestinal mucosa, then it is used during meals.
The dose of the suspension is determined based on the age and weight of the child. So, children from six months to twelve years old are advised to take 8 mg per kilogram of weight. The recommended volume can be divided into several receptions, or the entire volume can be drunk at a time.
Children from twelve years old having a body weight of 50 kg or more are prescribed an adult dosage, which can reach 400 mg per day. The course of treatment is determined by the course of the disease.
Side effects of the drug "Cefix"
The instruction (a description of the drug warns of the importance of following all the recommendations) indicates that the drug can cause a number of side effects, which include:
- diarrhea, nausea and pain in the abdomen;
- dyspepsia, colitis and flatulence;
- various rashes on the skin (rash, itching and hives);
- malfunctioning of the lymphatic system;
- allergic reaction and serum sickness;
- dry mouth and general weakness;
- impaired kidney function;
- fungal infections of the female genital organs;
- dizziness, fatigue and headache;
- excessive sweating, baldness and epidermal necrolysis (death of the upper layer of the skin).
In some cases, an overdose was observed, which manifested itself in the form of diarrhea, dizziness, nausea and vomiting. If such symptoms are detected, gastric lavage should be done, antihistamines should be taken, oxygen therapy should be done.
Interactions with Other Medicines
The nephrotoxicity of the drug increases if you use it simultaneously with Furosemide and aminoglycosides.
The duration of the prothrombin period with or without bleeding manifestations increases with the use of Cefix with anticoagulants.
During therapeutic treatment it is forbidden to drink alcoholic and tonic drinks.
Analogues of the drug
More than once proved its effectiveness in the fight against infectious diseases Cefix (suspension for children). The instruction (the price of this drug is quite high) describes in detail all the methods of treatment, as well as indications and contraindications. If this tool does not work, then you can always choose the appropriate analogue. According to the content of the active substance and the form of release, the medicine is similar to such medicines:
The above drugs are released in powder form for suspension and are suitable for children. Capsule analogues include Supraks Comfort, Supraks Solutab, Lopraks and Flamifiks.
These funds in their effect on the body can completely replace Cefix (suspension for children). The instruction (the price may vary slightly depending on the margin in the distribution network) warns that you should consult your doctor before using this antibiotic.
Cost of medicine
This is a new drug that has gained popularity relatively recently. Despite this, you can find it in every pharmacy. The cost of funds ranges around 900 rubles. The price of Cefix may slightly change in the direction of decreasing or increasing. Instructions for use, description, reviews of mothers talk about the effectiveness of this drug in the treatment of tonsillitis and other diseases, so the medicine costs this money.
Reviews about the drug
“Cefix” - suspension (instructions for children warns that before taking the medication you should familiarize yourself with the contraindications), about which there are many positive opinions. Women note the effectiveness of the drug. They say that the improvement in the condition of the child came on the second day of his admission. The throat ceased to hurt, the cough disappeared, fatigue and other symptoms of the common cold passed. It is claimed that the tool has a wide spectrum of action and, therefore, helps to cure tonsillitis, tracheitis and infectious diseases of the intestine. More than once the drug proved to be effective in treating diseases of the upper respiratory tract, where it acted quickly and effectively. Like children, because it has a bright and delicate taste of strawberries.
Among the shortcomings of the drug, the reviews highlight an allergic reaction, high cost and short shelf life of the diluted suspension. Women say that for a child aged 10-12, it is necessary to buy two bottles, since one is not enough for the full course of treatment. A certain part of people did not see any effect after using this medicine and considers its useless.
Conclusion
Cefix is an antimicrobial agent that quickly heals pulmonary and other infectious diseases. Rarely causes side effects. It differs from others in its effectiveness.