The article will talk about drugs-inhibitors of PDE-5. It is known that due to erectile dysfunction the work of other organs and systems is not disturbed, it does not harm the health and life of a man, however, such a sexual disorder is very difficult to perceive from a psychoemotional point of view. A man has to worry about the quality of an erection and potency for almost his entire conscious life, even if there are no visible reasons for concern.
Currently, there are a large number of natural remedies that help prevent erectile dysfunctions, and stimulators of strong erection with complete dysfunction. The most effective inhibitors are PDE-5, or type 5 phosphodiesterase, which provide a man with a 100% erection, regardless of the etiology of the disorder and its severity.
What are the causes of erectile dysfunction?
If earlier the main causes of erectile dysfunction were considered different psychological problems, now the opinion has changed. It is now known that the violation in 80% of cases has an organic origin and appears as a complication of various somatic diseases.
The main organic causes: hypogonadism (dishormonal conditions); angiopathy; neuropathy.
The prevalence in heart and vascular pathology is very high, more than 50% of the stronger sex with such diseases have erectile dysfunction, but not every patient uses PDE-5 inhibitors - a kind of "gold standard" in the treatment of sexual function defects. Why is this so? Unfortunately, until now, patients are extremely wary of such remedies, despite the fact that their effectiveness has already been proven.
General therapeutic principles
Before choosing tablet type 5 phosphodiesterase inhibitors for the treatment of disorders of the reproductive system, each man must determine the mental and somatic prerequisites for such disorders. The following factors can affect an erection:
- the presence in the body of concomitant systemic pathologies;
- the use of potent drugs;
- lifestyle (bad habits, passive pastime, overeating);
- frequent depression and stress.
Specialist help
If after elimination of such prerequisites for dysfunction, the violation does not pass, you can first use the help of a sexologist or psychotherapist. A conservative treatment method can be nutrition correction, exercise, refusal from addictions, weight loss, elimination of stressful situations leading to depression. Among other things, an erection can be restored by treating the underlying disease, for example, hormonal disorders, diabetes mellitus, etc.
What does treatment suggest?
The medication method of treatment involves:
- the use of tablets is sublingual and oral;
- injections into the urethra or the cavernous bodies of vasoactive drugs.
The achievement of a stable erection can also be helped by the use of shortly before the intimate connection of drugs alpha-1-blockers or type PDE5 inhibitors.
special instructions
It should be noted that taking such medications is possible only after consulting a doctor. He will determine the dosage acceptable in each case, since with irrational use, the drug may be ineffective or cause side effects.
Expediency of application
The use of PDE-5 inhibitors is advisable, this is proved by the following facts:
- such drugs are adapted first-line treatment;
- the use of such funds has been going on for more than 30 years;
- repeated clinical trials have proven their effectiveness;
- drugs are convenient to use;
- in practice, millions of men have proven the safety of such products.
Instructions for the use of drugs
Currently, the most popular in the treatment of erectile dysfunction are medications type 5 phosphodiesterase inhibitors, which have valuable pharmacokinetic properties, are characterized by clinical efficacy and a relative absence of harm.
Pharmaceutical companies produce a large number of drugs that stimulate an erection. PDE-5 inhibitors include the following drugs.
Sildenafil. He is also a selective PDE5 inhibitor, which was first produced in 1996. Film-coated almost white or white round tablets, biconvex, having an almost white or white core in cross section.
The active ingredient is sildenafil nitrate, in one tablet is 28.09 mg, which corresponds to 20 mg of sildenafil. Auxiliary components: microcrystalline cellulose, anhydrous calcium hydrogen phosphate, croscarmellose sodium, magnesium stearate.
The film membrane contains talc, hypromellose, titanium dioxide, polyethylene glycol 4000 (macrogol 4000).
The tablet should be taken one hour before an intimate relationship, the approximate daily dosage ranges from 50 to 100 mg. The effect of the drug persists for four hours.
Phosphodiesterase inhibitor 5 type "Vardenafil". This is an improved and new highly selective inhibitor, which has proved its high effectiveness to biological equivalents by repeated clinical studies (in the form of monohydrochloride trihydrate).
Such a drug is taken once a day thirty minutes before intimacy, its effect lasts 4-5 hours. The daily dosage is approximately 10-20 mg of vardenafil.
The drug "Tadalafil" is a selective inhibitor that has been sold recently, but is highly effective in restoring erectile dysfunction. "Tadalafil" is currently produced in the form of tablets, in which the active component is contained in 2.5; 5; 20 and 40 mg. As an active ingredient, the drug "Tadalafil" includes a chemical substance of the same name. In the form of excipients, the preparation contains the following components: hyprolose; lactose; croscarmellose sodium; microcrystalline cellulose; magnesium stearate; sodium ilauryl sulfate; titanium dioxide; triacetin.
The principle of action and structure are somewhat different from Sildenafil, its selectivity is less than that of the first agent. The effectiveness of the composition of the tablets lasts 36 hours. The drug should be taken in an amount of 10-20 mg shortly before intimacy. In addition, such a tool is allowed to combine with alcohol and food, which is an indisputable advantage for patients.
"Udenafil." A modern reversible selective inhibitor that provides a man with the ease of achieving an erection state. Tablets should be taken 30-90 minutes before possible sexual contact, and its effect will remain for 12 hours. It is very important to comply with all the conditions that are specified in the instructions, since drugs of this type have contraindications and side effects.
"Avanafil." The next representative of the PDE-5 inhibitor group, which also contributes to the expansion of blood vessels and allows blood to enter the intimate organs more easily, providing an erection of 100%. The tablets contain as an active ingredient avanafil. The composition of the drug also includes mannitol, hydroxypropyl cellulose, fumaric acid, calcium carbonate, iron oxide and magnesium stearate.
The medicine should not be taken if there is an allergic reaction to at least one of the components listed above. The therapeutic efficacy of the drug is 80%, a tablet must be taken 15-20 minutes before the upcoming sexual contact. The effectiveness of the drug lasts for six hours, it can be combined with alcohol and food. In this case, the average dosage is approximately 100 mg per day.
What can be achieved?
It is worth noting that most drugs of this type to stimulate erectile function allow for vascular expansion, muscle relaxation, and due to this an erection will be much easier to achieve.
In addition, such funds are not recommended to be combined with the intake of alcoholic beverages or fatty foods, as this can to some extent reduce the absorption and effectiveness of the composition of the tablets.
Before taking the above medicines in the form of tablets that restore erectile function, each man needs to consult about the optimal dosage of a particular inhibitor, since an overdose can cause significant side effects.
Contraindications for taking PDE-5 inhibitors
It is known that preparations with synthetic components in any case have a well-defined list of contraindications that can cause a number of side effects. The same can be said for PDE-5 inhibitors, which are contraindicated in the following situations:
- the person has not reached the age of majority;
- hypersensitivity to the components;
- the parallel use of tablets containing organic nitrates;
- disorders and pathologies of the functionality of the heart and blood vessels, in which increased sexual activity is unacceptable;
- taking "Doxazosin" and other drugs for erection;
- loss of vision with anterior non-arterial ischemic neuropathy of the optic nerve;
- chronic kidney failure and the use of such stimulants more than twice a week;
- alabsorption, lactase deficiency or lactose intolerance;
- glucose-galactose malabsorption.
Side effects
The most typical undesirable effects of the irrational use of type 5 phosphodiesterase inhibitors are vomiting, nausea, headaches, visual disturbances (light perception and lack of concentration), dizziness, rhinitis and swelling of the nose, shortness of breath, redness of the face. If these symptoms occur, consult a doctor.
The interaction of "Trazodone" and type 5 phosphodiesterase inhibitors
Trazodone is a selective serotonin reuptake inhibitor, it also blocks 5-HT2A receptors and moderately inhibits serotonin reuptake.
"Trazodone" can be used both in a separate treatment course and in combination with other means to get rid of erectile dysfunction, including with androgens and type 5 phosphodiesterase inhibitors, that is, they combine with each other, their interaction is effective.