The medicine "Tienam", analogues of the drug (means "Grimipenem", "Tsilapenem" and others) belong to the category of antibiotic medicines. The active ingredients are cilastatin and imipenem. The last substance - a derivative of thienamycin - belongs to a new class of carbanems (beta-lactam type antibiotics). Imipenem inhibits synthesis in the bacterial cell wall, has a bactericidal effect on a wide range of strains of pathogenic gram-negative and gram-positive pathogens, as well as on anaerobes and aerobes. Sodium cilastatin, an enzyme of a specific type, inhibits the metabolism of imipenem in the kidneys, significantly increases its level (unchanged) in the urinary tract.
The drug "Tienam." Instruction Price. Indications
The cost of the solution for injection into the muscle is about 500 r, the solution for infusion - from 5000 r. The medicine is prescribed in the treatment of pathologies of the infectious-inflammatory type, provoked by pathogens sensitive to it. In particular, the “Tienam” remedy recommends the use of it for gynecological infections, lesions in the lower parts of the respiratory system, and in the organs of the abdominal cavity. The indications include infectious diseases of the skin, joints, soft tissues, bones, with mixed lesions. In the form of infusions, the medication is also prescribed for septicemia, endocarditis.
The medicine "Tienam." Instructions for use
The method of administration and dosage per day are set personally in accordance with the severity of the infection. The total amount of medication is distributed evenly taking into account the level of sensitivity of microbes, kidney activity and patient weight. Intravenous infusion is advisable in the initial stages of therapy for endocarditis, bacterial sepsis and other life-threatening severe infections, including lesions in the respiratory system, with severe complications, and shock conditions. With a mass (average) of 70 kg and stable renal function, 1-2 g is prescribed in three to four infusions. A maximum of 4 g or 50 mg / kg is allowed to be administered per day. Intravenous infusion is performed within 20-30 minutes at a dose of less than 500 mg and for 40-60 minutes with an appointment of more than 500 mg. If nausea occurs, the rate of infusion should be reduced. For children from three months with a weight of less than forty kilograms, a dosage of 15 mg / kg after six hours. A day is not allowed to enter more than 2 grams. With a weight of more than 40 kg, the dosage is for an adult.
The drug "Tienam." Instructions for use. Contraindications
The drug is not prescribed for increased susceptibility to the components of the drug, to local amide anesthetics. Contraindicated in patients with severe shock, pregnant and lactating. The drug "Tienam" instruction for use does not recommend for disorders of intracardiac conduction. Caution during treatment should be exercised with children, elderly patients. If necessary, adjust the dose and rate of infusion in accordance with the state.