"Paracetamol" refers to antipyretics and has a powerful analgesic effect. The drug is of several types - tablets, syrup, suppositories. What is the shelf life of Paracetamol in these dosage forms?
Paracetamol in tablet form is intended for oral use. The drug is dispensed in blisters of ten and twelve tablets.
One tablet contains in its structure 250, 325 or 500 milligrams of the active substance - paracetamol, as well as a number of auxiliary components.
In one candle, there may be a different concentration of the active substance - 50, 100, 250, 500 milligrams. The shelf life of Paracetamol in children's suppositories is thirty-six months.
The syrup is available in bottles of 100 milliliters, the amount of active component is 120 milligrams.
Pharmacological actions
The drug has an antipyretic, as well as analgesic and mild anti-inflammatory effect on the body. When the tablet penetrates the organs of the stomach and intestines, the active component is absorbed into the bloodstream.
The spectrum of influence of "Paracetamol" is based on the inhibition of prostaglandin compounds - components that are considered inhibitors of inflammatory and pain processes in the body.
Indications
"Paracetamol" is recommended for patients with the following conditions and diseases:
- Migraine (severe headaches).
- Toothache.
- Algodismenorea (painful menstruation, accompanied by a violation of the general condition).
- Otitis (a disease that is an inflammatory process in the ear).
- Myalgia (a pathological condition characterized by the appearance of muscle pain).
- Post-traumatic pain (symptom complex, including dizziness, headache, difficulty concentrating, nervousness, sleep disturbances and personality disorders).
- Neuralgia (damage to the peripheral nerves, characterized by bouts of pain in the innervation zone of a nerve).
- Febrile conditions.
What ailments are forbidden to take "Paracetamol"?
Before using the drug, the patient is advised to read the instructions for him. Tablets are contraindicated in the following cases:
- Individual intolerance to substances.
- Severe damage to the liver and kidneys.
- Liver disease.
- Children under twelve years of age.
- Pregnancy in the first trimester.
- Chronic alcoholism
With extreme caution, the drug is recommended to be used in the second and third trimester of pregnancy and during breastfeeding. "Paracetamol" after the expiration date is forbidden to use, it must be disposed of.
Mode of application
A single and daily dosage of a medication is determined by the doctor depending on the age, weight of the patient, the intensity of the pain syndrome or heat.
For children 6-12 years old, a single concentration of the drug is 250 milligrams, daily dosing should not exceed one gram.
For adult patients, a single content of the active substance is 325 or 500 milligrams, in severe situations it is permissible to use one gram of the drug. A day, adults can take no more than 4 grams of the drug.
The tablet can be taken regardless of food intake, washed down with water. Between the use of the drug, it is necessary to withstand a period of time of at least four hours, otherwise the likelihood of negative phenomena increases.
The duration of treatment should not exceed five days, if therapy continues, then it is necessary to monitor the performance of the liver.
The use of the drug during pregnancy
In the first trimester, the drug, like any other drugs, is contraindicated, as this can adversely affect the intrauterine development of the unborn baby.
In subsequent trimesters, "Paracetamol" can be used only according to the indications and under the supervision of a medical specialist, only in cases where the likely benefit to the mother outweighs the risks to the baby.
The use of the drug during lactation is important to coordinate with the doctor. Since “Paracetamol" is excreted in milk, therefore, if therapy is necessary, breastfeeding should be interrupted.
Adverse reactions
During the use of tablets, a person may experience certain negative manifestations. It:
- Nausea.
- Vomiting
- Diarrhea.
- Pain in the stomach.
- Bloating.
- Liver enlargement.
- Increased activity of hepatic transaminases.
- Increased heart rate.
- Change in blood pressure parameters.
- Tachycardia.
- Anemia.
- Decreased platelet and white blood cell counts.
- Pyuria.
- Interstitial nephritis.
- Glomerulonephritis.
- Impaired renal function.
- In severe cases, the development of renal failure.
- Angioneurotic edema.
- Skin rashes.
- Redness.
If such negative phenomena occur during the use of Paracetamol, the patient must consult a medical specialist.
Overdose
With prolonged use of tablets at elevated doses, a person quickly develops symptoms of poisoning, which are clinically manifested as an increase in the above adverse reactions.
If you accidentally take a large number of Paracetamol tablets, you need to rinse your stomach as quickly as possible and take the patient to the hospital. If necessary, symptomatic therapy is carried out. The antidote for poisoning is "N-Acetylcysteine", it is used orally or intravenously.
Interaction
You can not use "Paracetamol" with "Rifampicin" at the same time, since in this situation the pharmacological effect of the first drug decreases.
When combining the drug with barbiturates or antiepileptic drugs, the likelihood of toxic liver damage quickly increases.
"Paracetamol" enhances the pharmacological effect of indirect coagulants, therefore, to avoid the development of bleeding, it is not recommended to combine these drugs.
Under the influence of Paracetamol, the therapeutic effect of Aspirin, Codeine and Caffeine is enhanced.
In order to avoid toxic damage to the liver and the occurrence of signs of poisoning, Paracetamol should not be taken in conjunction with other drugs in the structure of which this component is present.
Features
Patients who have severe liver disease in their medical history should always consult a doctor before starting treatment and it is advisable to take certain blood tests.
If you need long-term use of the medication, a person needs to monitor blood counts.
In pediatrics, "Paracetamol" is used in the form of a syrup (suspension) for oral use, which is allowed for children from two months.
Analogs of "Paracetamol"
The following drugs are analogues of the drug:
- "Panadol".
- Efferalgan.
- "Rolocin."
- Coldrex.
- Tilemin.
- Fervex.
- Tralgon.
- Cetanyl.
- "Opradol".
Before replacing the prescribed drug with one of the listed analogues, a single dose and age restrictions should be clarified with the doctor, in addition, some of these funds are combined and have a number of contraindications and restrictions. How long is the shelf life of Paracetamol in tablets?
Storage conditions
Tablets can be bought at a pharmacy without a prescription from a medical specialist. The average temperature for storing the drug is twenty-five degrees heat. Keep them away from children in a dark place.
The shelf life of Paracetamol in tablets is thirty-six months from the date of manufacture, which is indicated on the package itself. Do not use the medicine after the expiration date.
In pharmacies, the cost of a tablet preparation varies from 5 to 40 rubles. The average price of syrup is 150 rubles. The cost of candles varies from 40 to 50 rubles.
The shelf life of the paracetamol syrup after opening the bottle is one month. In closed packaging - twenty-four months.