How and why should I use the drug "Arthrosan"? Instructions, analogues and indications for the administration of this drug will be described below. We will also tell you about the form in which the mentioned medication and its substitutes are made, what components are included in their composition, what patients say about them, etc.
Form, packaging and description of the drug, its composition
In what form is the medicine "Arthrosan" sold? Analogs and the medicine in question themselves have different forms of release:
- Tablets. The active substance of this form is meloxicam. Also, its composition includes auxiliary elements in the form of lactose monohydrate, colloidal silicon dioxide, sodium citrate, povidone, potato starch and magnesium stearate. Arthrosan tablets (Russian and foreign analogues will be presented in the article) can have various shades of yellow. Such a drug is available in a flat form with a chamfer and a risk in the middle. It is packed in blisters that are placed in a cardboard box.
- Solution for intramuscular injection "Arthrosan" (injections). Instructions for use (analogues of this form are presented below) states that the composition also contains the main substance in the form of meloxicam. In addition, the solution also contains such additional components as sodium chloride, glycine, poloxamer, water, a unimolar solution of sodium hydroxide and glycofurol. This form of the drug is available in the form of a transparent and yellow-green liquid in ampoules, packed in cardboard boxes.
Forms of analogues and their composition
If it is impossible to use the drug "Arthrosan", you can apply the following analogues:
- Solution for intramuscular administration "Movalis". The active substance of this drug is meloxicam (auxiliary components: meglumine, poloxamer, glycofurfural, glycine, sodium chloride, sodium hydroxide, water d / i).
- Tablets of the cylindrical shape "Meloxicam". The active component of this medication is also meloxicam (excipients: microcrystalline cellulose, lactose, povidone, sodium citrate dihydrate, sodium carboxymethyl starch, colloidal silicon dioxide, calcium stearate).
- Tablets and Melbek injection. The active element of this drug is meloxicam (minor ingredients: povidone, anhydrous lactose, magnesium stearate, microcrystalline cellulose, sodium citrate, crospovidone, colloidal anhydrous silica).
The mechanism of action of the medication "Arthrosan" and its analogues. Pharmacokinetics
How does the drug "Arthrosan"? Analogs and the medication itself, which contains such an active substance as meloxicam, are derivatives of oxicam. They have an anti-inflammatory effect, blocking the enzyme cyclooxygenase-2 and the synthesis of prostaglantins, which are directly involved in the arachidonic acid cycle.
After the use of drugs, the activity of inflammatory mediators, as well as the permeability of the vessel walls, are significantly reduced. This slows down reactions with free radicals.
The analgesic effect of the drugs is due to a decrease in the activity of the interaction of nerve endings and prostaglantins.
What pharmacokinetic features does the Arthrosan medication have? Analogs and the drug itself reach a maximum concentration in the blood within 3-5 days. Medicines bind well with proteins (about 99%). Their metabolism passes in the liver, as a result of which 4 metabolites are formed. However, they do not play any role in pharmacodynamic processes.
Drugs are excreted along with urine and feces.
Features of analogues
- The drug "Movalis" has a pronounced anti-inflammatory effect in any inflammation of the articular parts of the body.
- Medication "Meloxicam." The anti-inflammatory effect of this drug is associated with a decrease in the enzymatic activity of COX-2.
- The medicine "Melbek", like other analogues, belongs to the NSAID group.
Indications for use of the drug "Arthrosan" and its analogues
The analogue of the drug “Artrozan” and the drug in question are prescribed for the same reasons. All of the above medicines are intended to treat various inflammations of the joints, accompanied by pain:
- with osteochondrosis;
- with osteoarthrosis;
- with rheumatoid arthritis;
- with myositis;
- with ankylosing spondylitis;
- with radiculitis.
Contraindications to the use of the drug and its analogues
Under what conditions can not use the drug "Arthrosan", analogues of this drug? According to the attached instructions, the medicines in question (Arthrosan, Movalis, Meloxicam, Melbek) have the following contraindications for use:
- duodenal ulcer and stomach;
- drug allergy ;
- sensitivity to drug substances;
- intolerance to NSAID groups;
- bleeding in the digestive tract;
- bronchial asthma;
- age up to 15 years;
- polyps in the nasal cavity and nose;
- severe forms of renal, heart and liver failure;
- hyperkalemia
- hemophilia;
- lactation and pregnancy.
How should I take the medicines "Movalis", "Meloxicam", "Melbek" and "Arthrosan"?
The analogue of Movalis, as well as the preparations Meloxicam and Melbek are prescribed in the same dosages as Arthrosan.
Preparations in the form of tablets are prescribed once a day with meals, they should be washed down with plain water. The daily dose of these drugs is 7.5-15 mg (depending on the course of the disease and the intensity of the pain syndrome).
If medications cannot be taken orally, then doctors prescribe intramuscular injections. In this case, the daily dosage is also 7.5-15 mg. In this case, therapy is started with small doses and increased until the desired effect is achieved. It is highly recommended not to exceed the dose, as in this case, the risks of adverse reactions may increase.
Drug overdose
When using high doses of Arthrosan, Movalis, Meloxicam and Melbek, the patient may experience the following symptoms:
- indigestion;
- epigastric pain (bleeding in the stomach is possible);
- vomiting and nausea;
- impaired consciousness;
- respiratory arrest;
- asystole;
- violations in the liver and kidneys.
To eliminate such signs, the stomach is washed and the enterosorbents are prescribed.
Side effects of Arthrosan and its analogues
When taking the drugs "Arthrosan", "Movalis", "Meloxicam" and "Melbek" quite often there are such undesirable phenomena as:
- indigestion, belching, stomach ulcer, stomach bleeding;
- hepatitis, increased activity and level of liver enzymes, acute renal failure;
- bronchospasm, angioedema, peripheral edema;
- tachycardia, anaphylaxis;
- leukopenia, thrombocytopenia, anemia;
- headache, disorientation, drowsiness, dizziness, blurred vision;
- esophagitis, allergic reactions to the skin, photosensitization, skin itching;
- stomatitis, conjunctivitis and urticaria.
Drug interaction
Combine the drugs "Arthrosan", "Movalis", "Meloxicam" and "Melbek" with other medicines should be very careful. To find out which complex of drugs is acceptable for the treatment of joints and which is not, you should definitely consult a doctor and study the attached instructions. By the way, in the latter the following features of the drugs are indicated:
- in combination with drugs that lower blood pressure, their effectiveness is reduced;
- in combination with Cyclosporin and diuretics, the risk of developing renal failure increases;
- in combination with fibrinolytics, vitamin K antagonists, heparin and serotonin reuptake inhibitors, the patient may experience bleeding.
It should also be said that the medicines “Artrozan”, “Movalis”, “Meloxicam” and “Melbek” are especially carefully combined with lithium preparations, intrauterine devices, other NSAIDs, “Colestyramine” and “Methotrexate”.
Special recommendations for receiving analogues
The use of non-steroidal drugs for the treatment of joints can mask serious infectious diseases that occur in the patient's body.
With long-term use of drugs (longer than two weeks), it is necessary to monitor the work of the liver and kidneys.
If a person has a predisposition to the occurrence of a duodenal ulcer or stomach, then the medications Arthrosan, Movalis, Meloxicam and Melbek should be used with extreme caution. In this case, it is better to use the solution for intramuscular administration.
In the event of effects that are associated with a decrease in the speed of psychomotor reactions, it is necessary to stop working with complex mechanisms, and in no case to drive a car.
Drug analogue
"Arthrosan" in ampoules and tablets has many analogues in the modern pharmaceutical market (Russian and foreign). The main analogues were listed above. Also, similar drugs include:
- Mataren,
- Bi-Xikam
- “Medics”
- Movasin
- Lem
- M-cam
- Mirlox
- Mesipol
- Amelotex
- Melox
- Meloxam
- Movix
- "Meloflam" and others.
The closest analogue of the drug "Arthrosan" is the drug "Movalis". It is also an NSAID. This tool relates to derivatives of enolic acid. It has anti-inflammatory, antipyretic and analgesic effects.
Also, very often, the drug "Arthrosan" is replaced by "Meloxicam" or "Melbek". These are non-steroidal anti-inflammatory drugs that have analgesic, antipyretic and anti-inflammatory effects.
All of the above analogues are designed to reduce the pain that manifests itself in various diseases of the joints. It is rather difficult to distinguish among them particularly effective, since they all fully cope with the task.
It should also be noted that these drugs have similar side effects and contraindications (see above).
Patient Reviews on Medicines
Most people leave positive reviews about the drugs "Atrozan", "Movalis", "Meloxicam" and "Melbek". In their opinion, these medicines are available, but they are highly effective. They help many patients in the shortest possible time to get rid of pain syndromes, which are manifested in various diseases of the joints.
It should also be noted that the tablet form of these drugs has the same effect as injections.
Of the minuses of the Atrosan medication and the above analogs, adverse reactions in the form of stomach pains, headaches and dizziness are especially often noted.