Tablets "Acyclovir-Acre": instructions for use, analogues and reviews

In the article, we consider the instructions for use with the Acyclovir-Acre tablets. This is an antiviral medication.

Dosage forms of this drug are: tablets, packaged in 10 pcs. in blister packs. In a cardboard box there are 2 or 3 of such packaging. Also, tablets may contain 20 pcs. in darkened glass jars, in a cardboard box - 1 can. The medication is also made in the form of ointment, cream for external use.

The package contains instructions for use. In tablets "Acyclovir-Acre" 200 mg and 400 mg, the main active ingredient is the substance - acyclovir. The tablets are blue with light or dark blue blotches and white spots, the shape is flat-cylindrical, with a risk and a chamfer. Additional substances are microcrystalline cellulose, indigo carmine, magnesium stearate, starch sodium glycolate, water, polyvinylpyrrolidone.

Pharmacological effects

According to the instructions for tablets "Acyclovir-Acre", the drug is a synthetic analogue of purine acyclic nucleoside. It has a highly selective effect on the herpes virus. The transformation of acyclovir into tri-, di- and monophosphate of acyclovir gradually occurs under the influence of viral thymidine kinase inside human cells infected with the virus. As a result, acyclovir triphosphate begins to integrate into the DNA chain of the abnormal cell (deoxyribonucleic acid), and by competitive suppression of viral DNA polymerase prevents its synthesis.

The medicine “Acyclovir-Acre” inhibits the formation of new rash elements, reduces the likelihood of spreading the pathogen and visceral complications, enhances the formation of crusts, and alleviates pain in the acute stage of herpes zoster.

As indicated by the instructions for tablets "Acyclovir-Acre" when taken orally, absorption in the digestive tract is 20%. A relatively weak binding of the main active element with plasma proteins is observed. The half-life in most cases is three hours. In cerebrospinal fluid, the level of this substance corresponds to 50% of the level in the blood. During the biological transformation of acyclovir, the formation of 9-carboxymethoxymethylguanine is observed. This active substance is excreted by the kidneys in the amount of 10-15% of the drug in the form of metabolites or unchanged.

Indications for appointment

Instructions for tablets "Acyclovir-Acre" are very detailed. The drug is prescribed to patients with the development of the following diseases:

• infection of the skin and mucous membranes provoked by Herpes simplex (both types), including cases of primary and secondary genital herpes;
• primary, as well as recurring infectious processes caused by Varicella zoster viruses (chickenpox, shingles);
• cases of severe immunodeficiency in HIV infection and after bone marrow transplantation operations (detailed clinical picture, early clinical symptoms, stage of AIDS) - as part of combination therapy;
• for preventive purposes - primary and recurrent infectious processes provoked by Herpes simplex (both types) in people with immunodeficiency;
• prevention of exacerbation of recurrent infections caused by Herpes simplex (both types) in patients with adequate immune status.

List of contraindications

The medication "Acyclovir-Acre" has some contraindications for use, the list of which includes the following conditions:

• pregnancy, lactation;
• high sensitivity to certain active elements of the drug and ancyclovir.

With some caution, this pharmacological drug should be prescribed for a variety of neurological disorders (including a history), with dehydration, and renal failure.

Rules for admission and dosage

What else does the instruction tell us? Acyclovir-Acre tablets are taken orally with or after meals, washed down with water. The dosage regimen is determined by doctors depending on the clinical manifestations and severity of the condition of a particular patient.

Recommended dosages:

1. Treatment of infections of the skin and mucous membranes provoked by Herpes simplex: patients older than 2 years are prescribed 0.2 g 5 times a day (after 4 hours in the afternoon, with an interval of 8 hours at night). The duration of the course is 5 days, if necessary, the course of treatment can be extended.
2. For the prevention of recurrence of the infectious process caused by Herpes simplex in people with a normal immune response: 4 times a day, after 6 hours, 200 mg each. According to the instructions for tablets "Acyclovir-Acre."
3. For the treatment of Varicella zoster infections, patients weighing more than 40 kg are prescribed 0.8 g 5 times a day (after 4 hours). The duration of the therapeutic course is 10 days. For children after 2 years, a pharmaceutical agent is calculated at 0.02 g per kilogram of weight - 4 times. Course duration - 5 days.
4. With severe immunodeficiency, including cases of an expanded clinical picture of HIV infection or after a bone marrow transplant procedure (as part of combination therapy), it is prescribed 5 times a day according to the instructions for the use of Acyclovir-Acre tablets, 400 mg each.
5. Therapy of herpes zoster - for adults, as well as children after 6 years of age, is prescribed at 0.8 g 4 times - 5 days.

The highest daily dosage for all categories of patients with various pathologies is 3.2 g.

Side effects

In accordance with the instructions for tablets "Acyclovir-Acre" 400 mg and 200 mg, a pharmacological agent can cause the following negative reactions:

1. CNS - weakness, cephalgia, drowsiness, excessive fatigue, hallucinations, dizziness, tremor.
2. Allergic symptoms - skin rashes.
3. Digestive system - a transient increase in the activity of liver enzymes, nausea, hyperbilirubinemia, abdominal pain, diarrhea, vomiting.
4. The hematopoietic system - leukopenia, erythropenia.
5. Other adverse reactions are baldness, fever, and increased levels of creatinine and urea in the blood.

Special recommendations for the use of the drug

During the use of this medication, the patient should consume a large amount of fluid to allow for enhanced hydration. In addition, constant monitoring of renal function, blood urea and creatinine is required.

Conducting multiple therapeutic courses in patients with immunodeficiency can cause the formation of virus resistance to the active substance of the drug.

During the treatment period, caution is advised when performing dangerous types of work, including driving a vehicle and mechanisms, since there is a certain likelihood of developing undesirable symptoms on the part of the nervous system.

Use of the drug during pregnancy and lactation

The medicinal components of this drug pass through the hematoplacental barrier, which is why it is strictly contraindicated to use it during pregnancy. It is possible to prescribe a drug during the gestation period only as a last resort, when, according to a specialist, the clinical effect for the mother exceeds the threat to the child.

Since the active element of the drug (acyclovir) is excreted in breast milk, the use of this medication during lactation is also contraindicated. In case of impaired renal function, the medicine should be used with some caution. With moderate and severe stages of such disorders, a decrease in the daily dosage of the drug is required.

Drug Analogs

The analogues of this drug are:

• Valtrex
• Arviron.
• Vero-Ribavirin.
• "Minaker."
• "Ribamidil."
• "Ribapeg."
• "Trivorin."
• "Familar."
• Alpizarin.
• "Vartek".
• Herpferon.
• "Gossypol."
• Imiquimod.
• "Condilinus."
• "Fenistil Pencivir."

Reviews about this medication

This drug is very popular and in high demand. Patients to whom it was prescribed observed the rapid onset of the result from such treatment and the disappearance of pathological symptoms. The only negative factor that characterizes this tool is the frequent cases of adverse reactions. Of these, the most common are manifestations of dyspeptic disorders, dizziness, lethargy, and excessive fatigue. Patients say that these manifestations are mild and do not interfere with a normal lifestyle. The pluses include accessibility in pharmacies (price - about 50 rubles). We reviewed the instructions for tablets "Acyclovir-Acre" 400 mg and 200 mg.