How to apply Trimistin ointment? Instructions for use, reviews of the product for external use will be presented later. You will also learn about what substances are part of the drug, how much it costs, whether it has analogues, and what contraindications patients should know.
Composition and packaging
The drug "Trimistin" (ointment), the instructions for use of which are contained in a cardboard package, include such active ingredients as miramistin and triamcinolone acetonide. As for auxiliary components, they include: purified water, stearyl and cetyl alcohols, propylene glycol and betacyclodextrin.
A translucent gel of white color and a gel-like consistency with a mild specific aroma goes on sale in aluminum tubes.
Pharmacodynamics
What is the drug "Trimistin" (ointment)? Instructions for use informs that this is a combination product intended for external use only.
Triamcinolone, which is part of the ointment, has a pronounced anti-allergic, anti-exudative and anti-inflammatory properties.
Entering into connection with specific receptors of proteins, the aforementioned substance is able to correct the expression of corticoid-dependent genes, as well as affect the synthesis of the protein itself.
Triamcinolone reduces the activity, release, and production of inflammatory mediators (histamine, lysosomal enzymes, prostaglandin, and kinin). It also reduces vasodilation and vascular permeability at the site of inflammation and inhibits the migration of cells to the focus.
The drug in question is involved in the stabilization of lysosomal enzymes in leukocyte membranes, interferes with the recognition of antigens and inhibits antibody replication. It also inhibits the release of interleukins and interferon gamma from lymphocytes and macrophages.
What other properties are inherent in the medicine "Trimistin"? The instructions for use report that the gel inhibits the release of inflammatory mediators by eosinophils, promotes the formation of lipocortin and stabilizes mast cell membranes.
In the presence of injured tissues, all of these effects are directly involved in the suppression of inflammatory reactions that occur with mechanical, chemical and immune damage.
As for such an antiseptic component as miramistin, it has an extensive spectrum of action. This substance has a bactericidal effect (hydrophobically affects the membrane of bacteria).
Features of the drug
How does Trimistin gel work? Instructions for use (analogues of the ointment are indicated below) reports that the effect of this medication extends mainly to gram-positive microorganisms, as well as to some gram-negative bacteria, including aerobes and anaerobes.
In addition, the drug in question adversely affects the non-spore-forming and spore-forming microflora in the form of monocultures and microbial associations (including hospital strains that are resistant to antibiotic therapy).
The antifungal activity of such an active substance as miramistin encompasses yeast-like and yeast fungi, ascomycetes and dermatophytes. This substance prevents the infection of wounds by activating the regeneration processes.
Pharmacokinetics
The chemical and physical properties of the drug, as well as the high molecular sorption polymers included in it, keep the active ingredients at the site of application and prevent their penetration into the systemic circulation.
Indications
When should Trimistin gel be used? Instructions, a description of the drug report that this medication is prescribed in the presence of skin diseases of inflammatory origin, including aggravated by a bacterial or fungal infection:
- eczema, parapsoriasis, lupus erythematosus;
- atopic dermatitis, Dühring's dermatitis, pemphigus;
- neurodermatitis, seborrheic dermatitis, skin lymphoma;
- psoriasis, photodermatosis, contact dermatitis.
Contraindications
What diseases prohibit the use of the drug "Trimistin" (ointment)? Instructions for use indicate some contraindications of an external agent. These include:
- pregnancy period;
- tuberculosis of the skin, which is concentrated at the site of application of the ointment;
- lesions of the skin of syphilitic nature;
- age up to 1 year;
- hypersensitivity to constituent ingredients;
- skin reactions that occurred after vaccination;
- oncological skin diseases.
The drug "Trimistin" (ointment): instructions for use
The medication in question should be used only externally. The ointment should be applied to damaged areas of the skin with a thin layer, rubbing lightly with the fingertips.
This procedure must be carried out twice a day for 7-10 days. After the end of therapy, the inflammatory process should completely stop, the skin should clear, and the itching should stop.
When exudate appears at the application site, the skin area should first be treated with a 1% solution of boric acid, 3% hydrogen peroxide or 0.05% chlorhexidine bigluconate, and only then use the medication.
The application of ointment using a sterile dressing is also allowed.
Side effects
The medication in question rarely causes side effects. Although in some cases, when applying the ointment, patients may still experience a slight burning sensation.
Drug overdose
When applying ointment to large areas of affected skin, a small amount of the drug can penetrate the systemic circulation. This phenomenon does not lead to toxic effects.
Drug interaction
The effectiveness of Trimistin ointment is significantly increased with the simultaneous use of antibiotics, antimicrobials and systemic antihistamines. It should be noted that the effectiveness of the gel under consideration is markedly reduced when it is combined with other external drugs, which include sorbents.
Special recommendations
The effectiveness of the ointment may slightly weaken when applied to skin areas that contain a large number of purulent-necrotic secretions. Therefore, before using this product, the covers should be carefully treated with a soap solution or antiseptic.
Cost and analogues
The price of the drug in question varies from 130-180 rubles. As for the analogues, this tool does not have them. If the Trimistin ointment is not suitable for you, then you should consult a doctor to replace it with similar medicines.
Reviews about the external tool
Now you know what the medicine “Trimistin” (ointment) represents. The price, instructions, analogues, reviews and indications of this drug are described in this article.
According to patient reviews, the mentioned tool does an excellent job of the task. It is very popular among those people who have been diagnosed with various skin diseases. It should be remembered that the drug in question is not recommended for a long time, and also exceed the dosage recommended by the dermatologist.