High blood pressure is a consequence of arterial sclerosis and the cause of serious heart damage. Individuals who are elevated by these indicators are diagnosed with Hypertension. Due to stenosis of some capillaries that have lost elasticity, an increase in pressure occurs in others. This inhibits microcirculation and increases the load on the heart.
"Lortenza" is a comprehensive antihypertensive medication. The drug is produced in tablet form, which combines two active ingredients: amlodipine and losartan. What is the price of Lortensa? About it further.
Structure
The structure of the drug includes the following active ingredients:
- amlodipine besylate;
- losartan A substance granules.
According to the instructions for use of "Lortenza", it is known that additional substances are:
- cellactose 80;
- cellulose;
- starch;
- sodium carboxymethyl starch;
- silicon dioxide;
- iron oxide yellow;
- magnesium stearate.
Lortenza tablets: indications and contraindications
According to the annotation, the drug is recommended for use in the treatment of patients with arterial hypertension.
Prohibitions for use are:
- Lowering blood pressure.
- Severe liver failure.
- Heart disease, in which the narrowing of the aortic opening occurs, which creates an obstacle to the expulsion of blood into the aorta with a contraction of the left ventricle.
- Pregnancy.
- Impaired renal function.
- Cardiogenic shock (left ventricular failure, which is characterized by a rapid decrease in the contractility of the heart muscles).
- Glucose-galactose malabsorption syndrome, provoked by inadequate absorption of monosaccharides in the digestive tract.
- Lactase deficiency (hereditary or acquired pathology, which is characterized by the absence or low content of the lactase enzyme).
- Age to eighteen.
- Breast-feeding.
- Individual intolerance.
- Low circulating blood volume.
- Severe heart disease.
- Cerebrovascular diseases (brain damage due to a gradual progressive damage to brain tissue against a background of chronic cerebrovascular accident).
- Angioneurotic edema (an acute condition characterized by the rapid development of local edema of the mucous membrane, subcutaneous tissue and the skin itself).
- Primary hyperaldosteronism (endocrine pathology, which is characterized by increased secretion of aldosterone).
- Artery stenosis of a single kidney (narrowing of the lumen of the vessel caused by congenital causes, atherosclerosis, inflammatory changes).
- Unstable angina (a disease that occurs when the myocardial circulation is disturbed due to narrowing of the coronary artery).
- Ischemia of the heart (damage to the muscles of the heart that is provoked by a deficiency or termination of microcirculation of the heart muscle).
- Acute myocardial infarction (ischemic heart disease, which occurs with the death of the muscles of the heart, due to absolute or relative deficiency of its microcirculation).
- Hyperkalemia (a disease that provokes an abnormally high blood potassium content).
- Arterial hypotension (a common pathological condition that manifests itself as a regular, persistent tonometer indicator below normal).
- Liver failure.
- Tachycardia (a sharp increase in heart rate, a sign of serious disorders).
- Severe bradycardia (a type of sinus rhythm disturbance that is controlled by the sinus node).
- Autosomal and dominant lesion, which is characterized by an increase in the wall of the left and occasionally right ventricle.
- Elderly age.
Mode of application
According to the annotation, the drug is taken orally, regardless of food intake, washed down with water. The dosage is 1 tablet per day. Lortensa (5 + 50 milligrams) is used when monotherapy with Amlodipine and Losartan does not lead to stable control of blood pressure.
Dosage is determined by titration of dosages of the active substance of the drug. If necessary, adjust the concentration of one of the active components in the composition of a fixed combined medication.
Adverse reactions
According to the instructions for use and reviews of Lortense, it is known that the active substance (amlodipine) provokes certain negative effects:
- Thrombocytopenia (a disease characterized by a decrease in the number of platelets circulating in the peripheral blood).
- Leukopenia (a decrease in white blood cells in plasma).
- Hypersensitivity reactions.
- Hyperglycemia (excessive serum sugar).
- Change of mood.
- Anxiety.
- Insomnia.
- Depressive disorders.
- Dysgeusia (a type of pathology of the gustatory sensory system, characterized by impaired activity of the bulbous nerve endings located in the oral cavity).
- Tremor.
- Hypesthesia (a pathological process in which there is a violation of sensitivity in the lower and upper limbs, individual parts of the body).
- Paresthesia (one of the types of sensitivity disorder, characterized by spontaneously arising sensations of burning, tingling, crawling ants).
- Peripheral neuropathy (a disease in which damage to the peripheral nerves occurs).
- Muscle hypertonicity (a violation of the usual condition, threatening many adverse effects).
- Visual impairment.
- Noise in ears.
- Palpitations.
- Atrial fibrillation (a violation of the functioning of the heart, which is accompanied by regular, fibrillation of certain groups of atrial muscle fibers).
- Ventricular tachycardia (a sharp increase in heart rate of more than 180 beats per minute).
- Arrhythmia (a pathological condition leading to a violation of the frequency, rhythm and sequence of excitation and contraction of the heart).
- Sensation of a rush of blood to the skin of the face.
- Marked decrease in blood pressure.
- Rhinitis (inflammation syndrome of the nasal mucosa).
- Dyspnea.
- Cough.
- Nausea.
- Pain in the abdomen.
Other side effects of "Lortenza 5 + 50"
The medication provokes the following negative reactions:
- Diarrhea.
- Intestinal obstruction.
- Dyspepsia (a violation of the normal functioning of the gastrointestinal tract, as well as difficult and painful digestion).
- Vomiting.
- Pancreatitis (an inflammatory disease of the pancreas).
- Gingival hyperplasia (a disease of the gum tissue, which can be found in most adults).
- Dry oral mucosa.
- Gastritis (inflammatory or inflammatory-dystrophic changes in the mucous membrane of the gastrointestinal tract).
- Jaundice (icteric staining of the skin and visible mucous membranes, due to the increased content of bilirubin in the blood and tissues).
- Hepatitis (inflammatory liver disease, usually of viral origin).
- Purple (pathological changes in the body in the body, characterized by the appearance of small capillary hemorrhages on the skin).
- Alopecia (hair loss, which leads to their disappearance in certain areas of the head or body).
- Stevens-Johnson syndrome (acute toxic-allergic disease, the main characteristic of which are rashes on the skin and mucous membranes).
- Exfoliative dermatitis (a serious illness that can provoke serious complications and even death of a person).
- Exudative erythema multiforme (acute inflammatory process affecting the skin and mucous membranes).
- Photosensitivity (skin reaction to sunlight with the participation of the immune system).
- Painful urge to empty the bladder.
- Nettle rash.
- Nocturia (a symptom of various diseases in which nocturnal diuresis prevails over daytime).
- Swelling of the ankles.
- Arthralgia (joint pains that are volatile in the absence of objective symptoms of joint damage).
- Myalgia (pain in the muscles).
- Muscle cramps.
- Rapid urination.
- Gynecomastia (breast enlargement with hypertrophy of glands and adipose tissue).
- Impotence.
- Erectile dysfunction (a disease in which insufficient pressure appears in the cavernous or cavernous bodies of the penis).
- Peripheral edema (a condition of the limbs, which is characterized by the accumulation of fluid in soft tissues).
- Fatigue.
- Pain
- Malaise.
- Asthenia (neuropsychic weakness, chronic fatigue syndrome).
Adverse reactions due to (active component) losartan:
- Urinary tract infection.
- Anemia (a pathological condition characterized by a decrease in hemoglobin concentration and in the vast majority of cases the number of red blood cells per unit volume of blood).
- Dizziness.
- Sleep disorders.
- Drowsiness.
- Migraine.
- Disorders of taste.
- Vertigo (these are neurological symptoms such as dizziness, loss of balance, shaky gait, blurred vision).
- Noise in ears.
- Hyperkalemia (a pathological condition that causes an abnormally high concentration of potassium in the blood).
- Hyponatremia (a condition in which the concentration of sodium ions in blood plasma drops below normal).
What side effects are observed on the part of the heart
On the part of the cardiovascular system, the following adverse reactions may occur when taking the drug "Lortenza":
- Angina pectoris (bouts of sharp chest pain that develop as a result of acute myocardial blood supply deficiency).
- Orthostatic hypotension (a clinical syndrome characterized by impaired ability of the body to maintain a normal level of blood pressure in an upright position).
Recommendations
During treatment with medicine, it is necessary to monitor the weight and consumption of table salt, as well as adhere to an appropriate diet. In addition, it is recommended that you visit the dentist from time to time and constantly maintain oral hygiene, as gingival hyperplasia is likely.
People who received "Losartan" monotherapy had an increased level of calcium in their blood. According to the annotations and reviews of Lortense, it is known that discontinuation of therapy is not required in any of these situations.
The simultaneous use of "Losartan" with salt substitutes, as well as drugs with potassium, potassium-sparing diuretic agents, which can increase the concentration of potassium in the bloodstream, should be justified.
According to the instructions to "Lortense", it is known that the use of the drug can cause transient arterial hypotension, which is accompanied by shortness of breath. During the use of the medicine, it is important for people to be especially careful when carrying out potentially dangerous types of work and driving, as dizziness may appear.
The drug is prohibited for use during pregnancy and during breastfeeding. A contraindication to Lortensa, as mentioned above, is also the age of eighteen.
Drug interaction
According to the instructions for use, it is known that other antihypertensive drugs can enhance the antihypertensive effect of Lortenza, and therefore their use should be justified.
In the process of taking medication with lithium medicines, an increase in neurotoxicity occurs. Losartan, which is part of Lortenza, is able to lower lithium excretion when used in combination with lithium-containing agents, and therefore monitoring the concentration of this element in the blood is important.
With the simultaneous use of the drug with inhibitors of the CYP3A4 isoenzyme, regular monitoring of signs of arterial hypotension and peripheral edema is needed.
When combined with beta-blockers, an exacerbation of the course of chronic heart disease is likely. According to the instructions and reviews about Lortense, it is known that with the simultaneous use of the medication with Dantrolene for intravenous administration, hyperkalemia and arrhythmia occur.
With complex therapy, medications with inducers of the CYP3A4 isoenzyme, it is necessary to constantly monitor blood pressure.
Substitutes
The analogues of Lortens are:
- "Vamloset".
- "Aprovask".
- Amzaar.
- Exforge.
- "Combisart".
- Amlosartan.
- "Lozap Plus".
- "Valsartan".
- "Valz N".
- "Kasark N".
- Atacand Plus.
- "Ko-Irbesan".
- "Diocor".
- "Fosicard N".
- "Combisartan."
The price of "Lortenza" varies from 240 to 650 rubles.
Opinions about the drug
Responses about the drug, as a rule, can be found in medical forums. As a rule, reviews about the drug "Lortensa" are positive, which confirms the beneficial effect of the use of antihypertensive drugs.
According to reviews, Lortensa is considered an effective drug that rarely causes negative reactions.