In the article, we will consider how to use "Dicinon" during pregnancy in the early stages.
One of the most dangerous symptoms during pregnancy can be revealed bleeding and the threat of spontaneous miscarriage. At the first signs of termination of pregnancy or bleeding in the early stages of the expectant mother, the drug Dicinon may be prescribed.
The composition of the medication
The pharmacological preparation “Dicinon” contains the main element - the substance etamzilate in a dosage of 250 mg (in tablet form) and in a dosage of 125 mg and 250 mg in the form of a solution for intravenous use.
Anhydrous citric acid, lactose, povidone K25, corn starch, magnesium stearate are used as auxiliary substances in the production of tablets.
Excipients of a solution for injection: water d / and, sodium disulfite, sodium bicarbonate (in some cases it is used to adjust the pH).
Indications for appointment
"Dicinon" during pregnancy in the early stages can be prescribed as a prophylactic and therapeutic agent for various types of internal and external bleeding. The medicine can be used orally, intramuscularly, intravenously, subconjunctival, retrobulbar, in the form of tampons and gauze dressings topically.
The main indications for the appointment of "Dicinon" during pregnancy in the early stages according to the instructions are the treatment and prevention of capillary bleeding of various origins:
- hematuria;
- threatened abortion;
- bleeding gums;
- metrorrhagia;
- nosebleeds;
- diabetic microangiopathy.
Pharmacological properties
The presented medicinal product has hemostatic properties (it stops bleeding or reduces its severity), which are due to the ability of the medication to activate the formation of thromboplastin in case of damage to small vessels (formed at the initial stages of the coagulation process). The use of the drug "Ditsinon" allows you to strengthen the formation of large mucopolysaccharides in the walls of capillary vessels, which protect protein fibers from trauma.
In addition, the medication helps to normalize the permeability of capillaries, increase their stability, improve blood microcirculation. The medicine "Ditsinon" does not have the ability to increase blood coagulability and does not contribute to narrowing of blood vessels and the formation of blood clots. The medication begins to act approximately 1-2 hours after oral administration and 5-15 minutes after the injection. The therapeutic effect of the drug is observed for 4-6 hours.
Release Forms
The pharmacological drug is available in the following forms:
- tablets containing 250 mg of the active element (ethamylate), one package contains 100 tablets;
- injection (ampoules) - contains 12.5% ​​solution in a volume of 2 ml, one box contains 50 or 20 ampoules.
Possible risks and side effects
According to the instructions for use, "Dicinon" during pregnancy in the early stages can provoke the occurrence of the following side effects:
- Nervous system: hyperemia of the face, headaches, dizziness, migraine.
- Dermatological reactions: redness of the skin, passing skin reaction.
- Digestive system: nausea, heartburn, pain in the epigastric region.
- Heart and blood vessels: lowering blood pressure.
As a rule, the reactions noted above are observed in pregnant patients who lead a passive lifestyle, violate the recommended dosage of the drug during the period of gestation.
Contraindications
There are some contraindications to the use of "Dicinon" during pregnancy in the early stages, including:
- acute forms of porphyria;
- thrombosis;
- intolerance to the components of the drug;
- hemorrhage due to the use of drugs of their anticoagulant category;
- thromboembolism.
Instructions for use
The instructions for the drug indicate that the medicine can be used only in cases where the benefit to the expectant mother is higher than the estimated risk to the health of the fetus.
In the early stages of pregnancy, Dicinon injections enhance the processes of platelet production in the bone marrow, as well as accelerate their transportation to the blood plasma. The action of this medication increases the intensity of the synthesis of thromboplastin, which is responsible for blood coagulation in the affected areas of the cover lining the inner surface of the capillary vessels. In this case, the platelet level remains in the optimal range, therefore, if the patient has a decrease in the level of such cells, it does not make sense to prescribe this medication to her.
Pills and injections of “Dicinon” during early pregnancy if bleeding develops act as a kind of stimulator of the processes of platelet attachment to the affected areas of blood vessels, after which a platelet plug is formed. This is what causes a bleeding stop in a pregnant woman.
A drug-based daily dosage of a drug is 10-20 mg per 1 kg of patient weight. What is the dosage of Dicinon tablets during early pregnancy? If a medication is prescribed in tablet form, the dosage is 1 tablet (250 mg) - 3-4 times a day. The effect with oral use will be noticeable after about 3 hours from the moment the drug is dissolved in the stomach. Its duration is observed for 5 hours.
The dosage of "Dicinon" during pregnancy in the early stages should be strictly observed.
Experts note that injections are much more effective than tablets of the drug, because the medication after injection immediately enters the bloodstream and begins to have a therapeutic effect, which is extremely important in the initial stages of pregnancy, when there is a threat of miscarriage.
Doctors prescribe the medicine "Ditsinon" not only for heavy bleeding in the early stages of gestation, but also for slightly noticeable spotting. This approach helps to eliminate the problem in the initial stages, without waiting for the deterioration of the pregnant patient. If there is a threat of miscarriage, it is impossible to prescribe this medication on your own in any case, since its administration is part of a comprehensive treatment. Without a proper approach to therapeutic measures, the medicine will only mask the symptoms, exacerbating the situation. Thus, the use of the medication is carried out exclusively under medical supervision.
Special recommendations
Before starting therapeutic measures using the described medical device in the early stages of pregnancy, the exact causes of bleeding should be diagnosed.
1 tablet of “Dicinon” medicine contains 60.5 mg of lactose (the maximum daily dose should not be more than 5 g). This medication should not be prescribed to pregnant patients with a lactase deficiency and congenital glucose intolerance, as well as for glucose-galactose malabsorption syndrome.
When staining an injection solution for intravenous or intramuscular use, it cannot be prescribed. The solution is intended for use in clinics and hospitals only. It can also be used topically: a sterile cotton swab or gauze should be soaked with a medicinal solution and a damaged surface is applied (for example, when removing a tooth from a pregnant woman)
Drug interaction
The introduction of “Dicinon” in early pregnancy injections at a dose of 10 mg per kilogram of body weight 1 hour before the injection of dextrans prevents their antiplatelet effect. The introduction of the drug "Dicinon" after the introduction of dextran into the blood does not contribute to the provision of hemostatic effects.
It is possible to use a medication with sodium menadione bisulfite and aminocaproic acid.
The drug is not pharmaceutically compatible (in the same syringe) with other pharmacological preparations.
This is confirmed by the instructions for use for "Dicinon" during pregnancy in the early stages.
Analogs
During pregnancy, analogues of the drug can be used, which include:
- Ethamsylate is a medication that increases the formation of mucopolysaccharides in the walls of capillary structures and increases the resistance of microvessels. This medicine helps to improve the permeability of capillaries in a pathological process, optimizes microcirculation, has a hemostatic effect, which is due to the activation of the formation of thromboplastin. The product enhances the formation of coagulation factor III, normalizes platelet adhesion, does not affect IPT, does not have hypercoagulation properties, and does not contribute to thrombosis.
- "Tranexam" - a hemostatic drug, an inhibitor of fibrinolysis. Specifically inhibits the activation of plasminogen and its conversion to plasmin. It has a systemic and local hemostatic effect during bleeding due to increased fibrinolysis (platelet pathology). Due to the processes of suppressing the formation of kinins and other active peptides involved in inflammatory and allergic reactions, it has anti-inflammatory and anti-allergic properties.
- “Vikasol” - an antihemorrhagic drug, a synthetic analogue of vitamin K, a cofactor for the synthesis of prothrombin and other coagulation factors (VII, IX, X) in the liver, helps to optimize this process.
Consider the reviews of gynecologists about "Dicinone" during early pregnancy.
Comments of gynecologists
Gynecologists respond quite positively about the use of this drug in the initial stages of pregnancy. They note that this medication can be used in the early stages of bearing a baby, even though its effect on the fetus has not yet been fully studied. If there is a risk of miscarriage, according to experts, the medicine helps to stop bleeding, significantly reducing the risk of spontaneous miscarriage.
Reviews about "Dicinone" in early pregnancy from patients
Women during pregnancy, especially at its initial stages, to which the Dicinon medication was prescribed, note that this remedy is quite effective and safe. It was used in case of abundant or minor spotting from the genital tract in the first trimester of gestation, when patients had an increased tone of the uterus and bleeding from capillary vessels. Women note that the drug practically does not cause adverse reactions, it is tolerated very easily and has a pronounced positive effect. In rare cases, they had dyspeptic symptoms that quickly disappeared after discontinuation of the drug.