Why is a drug like Endofalk necessary? The composition, analogue of the drug, as well as instructions for its use will be presented below.
Composition, form of laxative
In what form is the drug in question made? What does the instructions for use report about this? Endofalk is available in powder form for the preparation of an oral solution. It has a crystalline structure, white color, as well as a fragrant-fruity orange smell.
The active components of this medicine include macrogol 3350, sodium bicarbonate, sodium chloride and potassium chloride. Also, the composition of the medication includes inactive ingredients in the form of colloidal silicon dioxide, fruit flavoring, orange flavoring and sodium saccharinate.
“Endofalk” powder, the instruction for use of which is in a cardboard box, is contained in bags of laminated material.
Pharmacological indicators
What is this medication? What does the instructions for use say about it? Endofalk is a laxative. Its effectiveness and mechanism of action are due to the work of the components that make up the composition.
“Endofalk” is a combined preparation, which consists of a mixture of various electrolytes, as well as macrogol. They are intended for the preparation of an isosmolar solution.
The finished solution "Endofalk", the composition of which was presented above, is actively used in medical practice to cleanse the intestines. Thus, this remedy is referred to as laxatives.
Features of a medical device
As mentioned above, the active component of the drug in question is macrogol 3350 (i.e. polyethylene glycol). Thanks to it, an isosmolar solution can be created from the powder, which prevents the absorption of water in the intestines and stomach, and also contributes to the accelerated passage of the contents of the gastrointestinal tract and its release.
It should also be noted that polyethylene glycol has a high molecular weight. Due to the lack of metabolism and absorption, this element prevents unwanted gas formation, which is caused by the metabolizing action of bacteria.
As for the electrolytes of the salts that make up the drug, they prevent the process of disturbing the water-salt balance in the human body.
Pharmacokinetic features of a laxative
Is a laxative absorbed? What information on this subject contains instructions for use? “Endofalk” includes an element such as macrogol 3350. It is not absorbed from the gastrointestinal tract, nor is it metabolized. This substance prevents the absorption of other components of the drug in the intestine. In addition, it contributes to the rapid passage of the contents of the digestive tract and its excretion.
It should also be noted that the medication in question prevents the occurrence of increased gas formation. Due to diarrhea, the intestines are gradually emptied and cleansed.
The electrolytes in the finished solution are balanced in such a way as to prevent the reverse secretion and absorption of water and salts, preventing the violation of the water-mineral balance in the body.
Indications for use of the prepared solution
When is Endofalk used? The instruction states that the following conditions are indications for the appointment of this remedy:
- the process of preparing the patient for x-ray or endoscopic examination of the lower intestine;
- the process of preparation for surgical procedures, in which a complete absence of intestinal contents, i.e. chyme, is required.
Bans for the use of a laxative
In what cases can not use the drug "Endofalk"? Instructions for use, reviews claim that there are many contraindications to this tool. These include the following:
- violation of the gastric emptying process, the risk of gastrointestinal perforation or if it already exists;
- intestinal obstruction, as well as a suspicion of a similar pathology, severe colitis, which is in the acute stage;
- erosive and ulcerative lesions of the digestive tract, hypersensitivity to macrogol or another ingredient of the drug, toxic megacolon;
- severe renal failure, dehydration, cardiovascular failure.
It should also be noted that the medication in question is not prescribed for people with a disturbed swallowing reflex, as well as predisposed to aspiration, burping, patients with impaired consciousness.
Instructions for use
Endofalk is prescribed only to adults who have reached the age of eighteen. The drug is taken orally in the form of a freshly prepared solution.
The recommended dosage of this remedy is three to four liters. Ready laxative solution is taken in portions of 200 or 300 ml every twenty-five minutes.
How to cook such a preparation? To get one liter of drug solution, the contents of two sachets are dissolved in 500 ml of boiled chilled clean water. After that, the volume of laxative medication is adjusted to one liter.
According to doctors, in order to completely cleanse and release the intestines, it is necessary to prepare and then take 3 liters of the drug. The period during which it is required to take a laxative solution is three or four hours.
How should I use the drug "Endofalk"? Instructions, reviews of specialists say that such a solution should be taken orally by mouth. If it is impossible to use the medication on its own, it is administered through a nasogastric tube. As a rule, they do this the night before or in the morning on the day when it is supposed to examine the patient or perform an operation on the intestine.
It should also be noted that in the evening on the eve or in the morning on the day of the examination, the patient needs to refrain from eating any food.
Side effects
What adverse reactions should a patient be warned about before prescribing Endofalk? Instructions for use states that adverse events associated with the use of this drug may occur from the gastrointestinal tract. Typically, such adverse reactions include a feeling of fullness and bloating, irritation of the anus, nausea, cramping in the abdomen and vomiting.
In the event that the patient has at least one of the above symptoms, he needs to temporarily slow down the frequency of taking the solution or stop using it altogether until the side effects disappear.
Also, a person taking the drug "Endofalk" may experience the following negative reactions:
- sleep disturbance, general weakness, slight disorientation;
- arrhythmia, tachycardia;
- allergic reactions (urticaria, dermatitis, rhinorrhea);
- hypocalcemia (a very rare occurrence).
Drug overdose
In case of an overdose of the drug in question, the patient may experience severe diarrhea. Also, when taking a large amount of the drug, a violation of the water, electrolyte and acid-base balance in the body is possible. In such cases, the patient needs to replace the lost fluid, as well as constantly monitor electrolytes and pH.
It should also be noted that with a disturbed electrolyte and acid-base balance, the patient undergoes correction of the revealed changes.
With aspiration, the patient may develop pulmonary edema. This requires intensive treatment, including mechanical ventilation with high pressure.
Interaction with other means
The absorption of drugs taken prior to or with the use of Endofalk® solution is significantly reduced or completely stopped due to their rapid excretion from the gastrointestinal tract.
In the event that, for health reasons, the use of the drug cannot be canceled, then they switch to alternative routes of administration (for example, intravenous or intramuscular). If there are no such forms in the medicine, then the patient can be temporarily transferred to similar means.
The finished solution must not be mixed with other means, as well as with various additives, including sugar.
Analogs and reviews
Now you know how to use Endofalk powder. Instructions, analogues of this medication are discussed in this article.
If it is necessary to replace this medication, the following analogues are used: Defenorm, Fitolaks, Leovit, Norgalax, Forlax, Mikrolaks, Lavakol, Portalak, Normolak and others.
According to consumer reviews, the drug in question manifests itself as a highly effective laxative. However, its use is indicated only for medical examination and surgical procedures. In order to eliminate common constipation, experts recommend the use of other medicines designed specifically for this.