"Enap" refers to combination drugs. It has an active hypotensive and diuretic effect, is available in white tablets (10 units in contour packaging).
Enap. Indications for use
Among the antihypertensive drugs widely used today in medical practice, a special place is taken by the drug “Enap”. Instructions for use call several indications for its purpose:
- arterial hypertension;
- dysfunction of the left ventricle;
- heart failure.
It should be noted that enap is considered a prodrug, its activity appears after ingestion, when the components of the drug form enalaprilat by hydrolysis, which in turn inhibits ACE.
The active substances of the Enap preparation, in addition to enapril, include hydrochlorothiazide, which belongs to the group of thiazide diuretics. The mechanism of the combined action of the drug is explained by a decrease in the volume of sodium and fluid in the vessels, which leads to a decrease in cardiac output and blood pressure.
Patient with myocardial infarction is also prescribed Enap. Instructions for use indicate that taking the drug in such cases helps to reduce the affected area of necrosis and improve metabolism in the heart muscle.
Enap has a positive effect on renal circulation, while the drug does not increase the output of potassium from the body, which is important for arterial hypertension. This quality of the drug prevents the development of renal failure in patients.
Patients with cardiovascular diseases feel better when treated with Enap. Instructions for use recommend the drug due to the reduction in mortality observed in patients with congestive heart failure. The effectiveness of the drug does not decrease depending on the level of renin in the blood plasma, on the age of the patient, on his gender. In medical practice, there are no descriptions of cases of negative effects on the sexual function of the drug Enap. The instruction also indicates the absence of a negative effect of the drug on fat and carbohydrate metabolism in the body.
The medicine "Enap". Pharmacokinetic properties
Absorption of the active substance occurs mainly through the digestive tract (about 60%), and the absorption process does not depend on the time of eating. After 1 hour, the onset of the action of the Enap preparation is observed. The instruction indicates a pronounced therapeutic effect of the drug, which occurs a maximum of 6 hours after its administration, the active effect of the drug persists for a day.
Contraindications and side effects
The contraindications to the use of the drug "Enap" include:
- increased patient sensitivity to its components;
- porphyria;
- angioedema ;
- pregnancy;
- lactation period.
There are a number of side effects that occur in some cases of taking the medicine "Enap". The instruction warns against simultaneous treatment of patients with other diuretics, which can lead to impaired renal function. The work of the kidneys is restored when the drug is discontinued.
In rare cases, arterial hypotension is observed (has a short-term nature), patients complain of frequent headaches. In some patients, taking the drug provokes vomiting and nausea, muscle cramps and skin rashes.
The drug "Enap". Overdose
The main symptoms caused by an overdose of Enap, the instructions for use call signs of arterial hypotension. With their manifestation, the patient should be laid down, gastric lavage applied and activated charcoal given. Then measures should be taken to restore the volume of blood circulating in the body. To do this, the patient is injected (intravenously) with a solution of sodium chloride, and all vital systems should be monitored.
To avoid the troubles associated with an overdose or side effects of the drug "Enap", it is necessary to consult with your doctor before taking.