"Renec" refers to the pharmacological group of antihypertensive drugs of angiotensin converting enzyme inhibitors. It is used to lower blood pressure in various pathological processes of the cardiovascular system. Next will be considered instructions for use and analogues to "Renitek".
The drug is dispensed from pharmacy points in tablet form for oral administration. The main active trace element of the drug is enalapril, its concentration in one tablet is five, ten or twenty milligrams.
In addition, the medicine is also available under the name "Ko-Renitek." In addition to enalapril, the drug has another active substance in its composition - hydrochlorothiazide. It has a diuretic and antihypertensive effect.
Hydrochlorothiazide and enalapril can be used both in monotherapy and in complex treatment with other drugs to eliminate arterial hypertension. The antihypertensive effect of the active substances of the drug is complementary, and the pharmacological effect is prolonged, it lasts for twenty four hours.
Pharmacological properties
The main active microelement "Reniteka" inhibits the angiotensin-converting enzyme, which accelerates the reaction of conversion of angiotensin-one to angiotensin-two. As a result, the content of biologically active compounds is reduced, which are responsible for increasing the tone of the smooth muscles of the arterial walls, as well as narrowing their lumen and increasing the level of total blood pressure.
Enalapril is considered a highly specific compound. After absorption into the general bloodstream, it is transformed into enalaprilat, which has a pharmacological effect. The decrease in angiotensin-two content under the influence of enalaprilat also entails an increase in the level of renin, which leads to a decrease in the production of aldosterone. This helps to reduce blood pressure, since this hormone leads to a retention of fluid in the body due to an increase in sodium ions. In general, the active component affects the renin-angiotensin-aldosterone system.
Indications
The following medical conditions are considered the main medical indications for taking tablets:
- Hypertonic disease.
- Heart failure.
- Myocardial infarction or preinfarction condition.
- Angina pectoris.
The treatment and prevention of heart disease with a drug can slow down the further development of a pathological decrease in blood flow intensity, and also helps to reduce the severity of clinical signs.
Contraindications
Medical prohibitions on the use of tablets are several pathological and physiological conditions of the body, which include:
- Angioneurotic edema.
- Kidney disease.
- Individual intolerance to any of the components of the drug.
- The age is up to eighteen years, since the effectiveness and safety of the drug in this case is considered to be not reliably proven.
Before you start using the drug, you must make sure that there are no prohibitions on the use.
How to apply the drug?
Tablets are taken orally, usually once a day in the morning, regardless of food intake. The dosage and mode of use of the medication depends on the pathological process, which has become an indication for taking:
- Arterial hypertension - the initial dosage is ten to twenty milligrams once a day. With a mild course of the pathological process, the dosage is ten milligrams, with moderate and severe degrees, twenty milligrams. In general, the concentration of the active substance is selected by the doctor individually, while the daily dose should not be higher than forty milligrams.
- With renovascular hypertension, the course of treatment with Renitecom begins with a minimum dosage, which is five milligrams once in essence. Then the concentration of the active component may gradually increase depending on the pharmacological effect (as a rule, the effective pharmacological dosage is twenty milligrams once a day).
- In the treatment and prevention of heart disease, myocardial ischemia, the dosage is selected individually by a medical specialist, which depends on the use of other medicines.
Adverse reactions
As a rule, the medication is very well tolerated. In rare situations, negative reactions can occur, for example:
- Lowering blood pressure below standard.
- Myocardial infarction is ischemic necrosis of the heart muscle, which develops subsequently in an acute violation of coronary microcirculation.
- Deterioration of blood microcirculation.
- The appearance of chest pain.
- The development of Raynaud's syndrome is a vasospastic disease characterized by a paroxysmal disorder of arterial circulation in the vessels of the limbs (feet and hands) under the influence of cold or emotional excitement.
- Depressive disorders.
- Insomnia.
- Dizziness.
- Paresthesia - a disorder of sensitivity, characterized by spontaneously arising sensations of burning, tingling, crawling ants.
- The appearance of anxiety.
- Pancreatitis is a group of diseases and syndromes in which inflammation of the pancreas is observed.
- Stomatitis is an inflammation of the oral mucosa of various origins.
- Hepatitis is an inflammatory disease of the liver, usually of viral origin.
- Vomiting
- Constipation
- Dry mouth.
The occurrence of negative reactions after using the drug is considered an occasion to visit a doctor who will determine further therapy with the drug or adjust its dosage.
Features
To obtain the maximum pharmacological effect, as well as to prevent the occurrence of complications when using Renitek, it is necessary to thoroughly familiarize yourself with the instructions for use, and also make sure that there are no restrictions on admission, take into account a number of special instructions, which include:
- With extreme caution, the medication is prescribed to people with one kidney, in case of impaired glucose uptake, after a kidney transplant, in case of a violation of the hematopoietic system in the red bone marrow, as well as pathological conditions that are accompanied by a decrease in the volume of circulating blood.
- Before the start of treatment, as well as during its implementation, the level of total blood pressure is monitored.
- Periodic lowering of blood pressure is not considered a reason to stop taking the medicine.
Pills "Renitek": analogues
There are several analogues of the drug on the pharmacological market. The drug "Renitek" analogue and substitutes has the following:
- Miopril.
- Invoril.
- Renipril.
In addition, Renitek has a number of generics:
- Burlipril.
- Enalapril.
- "Vazolapril".
- "Enapharm".
Before replacing the original Renitec drug with a Russian analogue, consult a medical specialist.
Invoril
When taken orally, about sixty percent of the drug is absorbed from the gastrointestinal tract. Concomitant use of food does not affect absorption. It is exchanged in the liver by hydrolysis with the production of enalaprilate, due to the pharmacological activity of which a hypotensive effect occurs.
The binding of the active substance to blood proteins is sixty percent. The half-life of enalaprilat is eleven hours, it increases with renal failure. After oral administration of the drug, it is excreted from the body by the kidneys with urine. Invertil is considered an analogue and substitute for Ko-Renitek.
When taken, the initial dosage is 2.5-5 milligrams once a day. The average concentration of the active substance is twenty mg per day. With intravenous administration, 1.25 mg every six hours. To detect increased hypotension in patients with sodium deficiency and dehydration, which is due to previous treatment with diuretics, an initial dosage of 625 milligrams is administered.
Miopril
The drug is prescribed for the following diseases:
- Hypertension.
- Secondary arterial hypertension is an increase in pressure, which is associated with damage to the organs involved in maintaining its normal values.
- Heart disease.
- Diabetic nephropathy is a process of pathological changes in the renal vessels, which is caused by diabetes.
- Secondary hyperaldosteronism is an endocrine disease that is characterized by increased excretion of aldosterone.
- Raynaud's disease is a pathology in which arterial blood supply to the hands or feet is disturbed.
- Scleroderma is an autoimmune disease of connective tissue with a characteristic lesion of the skin, blood vessels, musculoskeletal system and internal organs (lungs, heart, digestive tract, kidneys), which is based on impaired microcirculation, inflammation and generalized fibrosis.
The drug is administered orally, the dosage is set individually. With hypertension, the initial concentration of the active substance is from ten to twenty milligrams per day, in the future, the dosage is adjusted individually.
Burlipril
Antihypertensive medication, which refers to angiotensin-converting enzyme inhibitors. Used for the treatment of high blood pressure and heart disease.
Under the influence of the drug, the capillaries expand, while the heart rate does not increase. The antihypertensive effect of Berlipril is accompanied by increased blood flow, but it does not affect the microcirculation of blood in the brain. Berlipril is the best analogue of Renitec.
According to the instructions, it is known that prolonged use of Berlipril helps to reduce left ventricular myocardial hypertrophy, as well as prevents heart disease and inhibits the increase in the volume of the heart chambers, without changing the thickness of the heart wall of the left ventricle. Improves microcirculation of the muscles of the heart with ischemia.
Enalapril
The drug is considered the best analogue of "Renitek". The medication refers to the antihypertensive drugs angiotensin-converting enzyme.
The main microelement "Enalapril" blocks the production of angiotensin-converting enzyme, which is responsible for the level of blood pressure.
It is used to eliminate pathologies that are accompanied by an increase in blood pressure.
Renipril
The active trace element in Renipril is enalapril, which is considered an inhibitor of the angiotensin converting enzyme, which is manifested by an antihypertensive effect.
Its spectrum of action is due to the ability to suppress the activity of the angiotensin-converting enzyme, which reduces the formation of angiotensin, which narrows the capillaries, and at the same time activate the production of prostacyclin and kinins, which have a vasodilating effect. "Renipril" is an analogue and substitute for "Ko-Renitek."
As a single drug, it is prescribed five milligrams once a day. In this case, the patient should be under the supervision of a medical specialist. In the absence of positive dynamics for two weeks, the dosage is increased to 10 milligrams.
If necessary, but subject to good tolerability of Renipril, it is possible to increase the daily dosage to forty milligrams. After about three weeks, they switch to maintenance treatment at a dosage of forty milligrams per day.
If the drug is prescribed to patients who are already receiving diuretics, they must be canceled in two to three days. If this is not possible, then the initial concentration of the active component should be 2.5 milligrams per day.
"Enapharm"
The medicine is intended to eliminate hypertension. The active ingredient is enalapril maleate, it is considered to be a representative of the group of angiotensin-converting enzyme inhibitors.
According to reviews of the Renitec analogue, it is known that the active substance prevents or weakens the metabolic effects of diuretic treatment and has a positive effect on structural changes in the heart and blood vessels.
How to store medicine?
According to the instructions, the shelf life of Renitek is 2.5 years. The drug must be kept in a dark, dry, inaccessible place for children at an air temperature of no more than twenty-five degrees. The average price of tablets varies from 40 to 160 rubles.
Opinions
According to reviews of the drug "Renitek" it is known that this is an affordable and effective medication. A convenient dosage regimen, a mild effect on the body, the possibility of prolonged use without the need to increase the dose are noted.
Some comments noted that in the first week of use, small adverse reactions can be observed. With further treatment, these signs go away on their own.
Therefore, it is not recommended to use the medicine without a doctor’s prescription. Reviews about "Renitek" tell us that a certain category of patients take it for quite a long time, note the effectiveness during the entire treatment. The instructions for the drug "Renitek" analogues are not indicated. They can only be prescribed by a doctor.