In the article, we consider the analogues of "Furazidine."
The medicine is an antimicrobial agent of a wide spectrum of exposure, which belongs to the category of nitrofurans. The principle of its action is associated with inhibition of the production of nucleic acids in the body. Under the influence of nitrofurans, there is a suppression of the functionality of the respiratory chain and tricarboxylic acid cycles (Krebs cycle), as well as inhibition of other biochemical processes of pathogenic microorganisms, which leads to a violation of the integrity of their membranes or cytoplasmic membranes.
Description
The drug is highly active against gram-negative rods: Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. and gram-positive cocci: Streptococcus spp., Staphylococcus spp.
The following types of pathogens are resistant to the main substance of this pharmacological preparation: Pseudomonas aeruginosa, Acinetobacter spp., Enterococcus spp., Most strains of Serratia spp. and Proteus spp ..
Depending on the concentration introduced into the body, it has a bacteriostatic or bactericidal effect. Against the main part of pathogenic bacteria, the bacteriostatic concentration is from 10 to 20 μg / ml. The bactericidal concentration is approximately 2 times higher.
Characteristics of analogues of "Furazidine"
The domestic pharmaceutical market has a large number of analogues of the drug “Furazidine”, in accordance with the terminology called “synonyms” - interchangeable by the action of medicines containing one or more identical active elements. When choosing synonyms, it is necessary to take into account not only their price, but also the reputation of the manufacturer.
Indications for appointment
Means "Furazidine", its analogues and synonyms are indicated for oral administration in the following pathologies:
- various urogenital infections (urethritis, cystitis, acute pyelonephritis);
- gynecological infectious diseases;
- infection of the skin and soft tissues;
- severe severe burns;
- for prophylactic purposes during urological surgical interventions (including catheterization, cystoscopy).
For local and external use, these medications are indicated for infectious and inflammatory pathologies of the pharynx and oral cavity, infected wounds.
Contraindications
The medicinal product "Furazidine" and its analogues cannot be taken in the following cases:
- chronic renal failure, severe;
- period of pregnancy, lactation;
- age less than 4 years;
- high sensitivity to furazidine and other nitrofurans.
How effective is Furazidine and analogues for cystitis?
Cystitis
Cystitis is a disease that approximately one in three women has met. In men, this problem occurs much less frequently.
Episodes of this pathological can go away on their own during the day, and in the near future will not be repeated, however, the development of a severe, extremely painful course of pathology, with the appearance of an impurity of blood in the urine, is possible. With cystitis, a lot of antibacterial drugs are prescribed, but some of them have long been ineffective, due to the development of pathogenic microorganisms resistance to them, which is fraught with the occurrence of complications and relapses of the disease. Others can be very unsafe in some clinical situations.
First line funds
Nitrofurans, such as Furazidine and analogues for cystitis, are first-line medications. They belong to the category of antimicrobial drugs that have long been used in the treatment of this unpleasant ailment. Common to these medicines is a bactericidal effect, low resistance of the main varieties of pathogens, but at the same time a significant frequency of adverse reactions. Every third patient, when taking nitrofurans, complains of nausea, vomiting, pain in the abdomen, dizziness, drowsiness. This group of drugs has a rather large list of contraindications in the form of liver, kidney and heart failure, and others.
Furadonin
This analogue of "Furazidine" is a synthetic antimicrobial drug from the group of nitrofurans. It is highly effective against staphylococcus, enterococcus, E. coli, Klebsiella, protea, enterobacteria and has a bacteriostatic effect, that is, it does not destroy microbes, but stops their growth.
The drug is available in the form of yellow tablets for oral administration with the active active substance nitrofurantoin.
The medicinal product "Furadonin" is shown as a medicine as part of combination therapy or self-treatment for infectious diseases of the urinary organs: urethritis, cystitis, pyelonephritis. It is also used for a symptom such as painful urination due to the presence of stones in the bladder cavity, for the prevention of inflammatory processes of the urinary organs after certain manipulations (cystoscopy) or surgical interventions.
The analogue of the drug "Furazidin" - "Furadonin" - can not be prescribed to patients with the following conditions:
- hypersensitivity to the drug;
- pregnancy 1 trimester, lactation;
- ailments of the liver and kidneys in severe forms;
- acute kidney failure;
- severe heart failure;
- cirrhosis of the liver;
- symptoms of anuria or oliguria;
- age up to 1 year;
- porphyria.
Furamag
Antimicrobial medication from the category of nitrofurans. Resistance to this medicine develops extremely slowly and, as a rule, does not reach a high degree. The principle of exposure is associated with the suppression of the production of nucleic acids. Depending on the level in the body, this pharmacological agent can realize its bacteriostatic or bactericidal property. Under the influence of the main component of the Furazidin analogue in pathogens, the development of the respiratory chain and the Krebs cycle, as well as other biological and chemical processes, is suppressed, as a result of which the destruction of their membrane structures is noted. As a result of this, pathogens emit less toxins, which is associated with an improvement in the patient's condition even before the growth of pathogenic microflora is suppressed.
This medication, unlike other analogues and substitutes of Furazidin, does not inhibit the immune system, but rather increases its activity: it increases the complement titer and the ability of leukocytes to phagocytize microbes.
Furamag is indicated for the development of infections caused by susceptible microorganisms:
- urogenital;
- gynecological;
- skin and soft tissue infections;
- complex infected burns;
- after urological operations (including catheterization, cystoscopy).
Contraindications to the use of this antimicrobial drug are liver, kidney, heart failure, age less than three years, lactation, pregnancy, lack of glucose-6-phosphate dehydrogenase.
"Furacilin"
The product is available in the form of a solution for external use, as well as in the form of tablets. The active substance in the medicine is nitrofuran, which blocks the reproduction of staphylococci, streptococci, Escherichia coli and other bacteria.
Tablets are packaged in blisters of 10 pieces (1) in a cardboard box, detailed instructions with a description of the characteristics are attached to the drug. Each tablet of the drug "Furacilin" contains 20 mg or 100 mg of the active substance - nitrofural, as well as a number of auxiliary additional components.
"Furacilin" does not irritate the mucous membrane of the urinary system, urethra and vagina. It is usually used for relapses of cystitis in the chronic stage of the disease and infections in all organs of the urinary system and infectious inflammation in the vagina.
For internal use - a daily dose of 0.5 grams of furatsilin, divided into 4-5 doses. Drinking the drug "Furacilin" is recommended for no more than 5 calendar days. Take the drug inside the body, it is necessary strictly as directed by the doctor. It is strictly forbidden to increase the dose of administration and to independently extend the medical course of treatment.
"Urofurogin"
The active component of this analogue is furazidine, a broad-spectrum antimicrobial compound from the class of nitrofurans. The principle of its influence is based on the suppression of nucleic acid synthesis. The drug inhibits the activity of the Krebs cycle and respiratory links, exhibits pharmacological functionality against many varieties of pathogenic bacteria.
The medicine “Urofuragin” is indicated for the treatment of inflammatory diseases of the urinary organs - urethritis, pyelonephritis, cystitis, as well as for the prevention of complications in the postoperative period.
Contraindications: renal and hepatic insufficiency, urosepsis, infection of the kidney parenchyma, pregnancy, lactation, age less than 18 years, lactase deficiency, impaired congenital sucrose absorption, hypersensitivity to nitrofurans. Relative contraindications are lung diseases, anemia, pathologies of the nervous system, porphyria, diabetes mellitus, folic acid deficiency, and vitamin B.
Is it possible to use "Furazidine", analogues and synonyms for children?
Use in childhood
Children, as well as adults, often suffer from diseases of the urinary organs, in particular cystitis and pyelonephritis, and nitrofurans are the most optimal solution to such problems in childhood. However, not all medications of this category can be used in the treatment of diseases in babies. Children from one year old are most often prescribed the drug “Furamag”, which is a more modern medicine, in comparison with the means “Furazidin” and “Furadonin”. This medicine causes a minimum of pathological adverse reactions in children, which allows it to be prescribed even to small patients.
From the same pharmacological group, the drug “Furazolidone” is very effective; this analogue of “Furazidine” can be given to children from the age of 4. The only thing that needs to be monitored is the reaction of the skin, since this medication is contraindicated in a child with a history of allergic reactions to drugs.
Special recommendations
According to the instructions for use with Furazidine and its analogues, it is recommended to drink a large volume of liquid to reduce the risk of side effects.
With the development of side effects, tablets should be stopped (toxic effects are more often observed in patients with low excretory activity of the kidneys).
During therapy, it is recommended to refrain from drinking alcohol, as it is possible to increase the negative effects.
Reviews about "Furazidine" and analogues
The drug "Furazidine" is one of the first pharmacological preparations of their category of nitrofurans. In its composition there is an active substance of the same name, which is the basis of all other drugs from this group. There are a lot of reviews about them, and almost all of them are positive.
Patients who treated urological diseases with the help of these medications note that they are most often tolerated normally, although side effects occur in almost every second case of use. They are expressed in violation of the digestive functions, nausea, impaired stool. In addition, many of the patients observed dark urine staining.
As for the effectiveness of these drugs, they very successfully cope with their task. The pathological manifestations of diseases such as cystitis and kidney inflammation during treatment disappear quite quickly - on the second day of admission.
The most preferred drugs from this group, judging by the information from the reviews, are Furamag, Furadonin and Furazidin.
We reviewed the instructions and analogues of "Furazidine."