"Cefixime" is a medication that can have a bactericidal and antibacterial effect. The drug is resistant to the influence of beta-lactamases and activity against many gram-positive and gram-negative microorganisms. The therapeutic effect against the background of its use is developing quite rapidly.
After oral administration, the active components of the drug are absorbed by 50%, the absorption rate is not dependent on meals. It binds to blood proteins by approximately 65%. Excretion from the body is carried out together with urine throughout the day, and the active components are excreted unchanged.
Indications for use
According to the instructions, "Cefixime" is often prescribed to patients with the goal of treating a variety of diseases of an infectious and inflammatory nature, provoked by microorganisms sensitive to the active component of the drug.
Most often used in therapy:
- Uncomplicated urinary tract infections.
- Exacerbations of chronic bronchitis.
- Acute bronchitis.
- Shigellosis.
- Pharyngitis.
- Streptococcal tonsillitis.
- Uncomplicated gonorrhea.
- Acute otitis media.
- Sinusitis
Contraindications
As the instructions to Cefixime indicate, he, like any medicine, has a number of contraindications that impede its use. If these restrictions are ignored, the development of undesirable consequences is possible:
- Individual susceptibility to derivatives of penicillin, cephalosporin, cefixime.
- Intolerance to other components that are part of the medication.
The use of Cefixime is also not recommended in the treatment of pediatric patients suffering from chronic renal failure, as well as those whose body weight is less than 25 kg.
The use of “Cefixime” during pregnancy can adversely affect the formation and development of the fetus.
Drug use
According to the instructions for use with Cefixim, we need to prepare a suspension from it before taking it. Use for this should be water - purified, boiled and cooled to room temperature. It will take about 35 ml of fluid.
The drug bottle is opened and pre-prepared water is poured into it (about half the volume of the bottle). Then it is closed with a lid and shaken thoroughly. Then the bottle is opened again and water is added to the full volume, closed and again shaken.
Each time before the next dose, shake the contents in a vial. Only after this suspension is ready for use. Allowed to use the drug at any time, regardless of meals. However, if the patient has an irritation of the digestive tract, it will be optimal to take the medication with food.
In accordance with the instructions for "Cefixime" 400 mg tablet should be washed down with plenty of water. Like suspension, they can be taken without regard to food.
Dosage
What else can you learn from the instructions for Cefixim? Most often, experts recommend using it in the following dosages:
- People weighing more than 50 kg are allowed to drink 400 mg of Cefixime per day according to the instructions for use. Reception can be carried out once or twice.
- Children with a body weight of 25-50 kg should take 200 mg once a day.
In order to treat tonsillopharyngitis provoked by streptococcus, a drug is indicated for a minimum of 10 days. The exact duration of treatment and dosage are determined by the doctor, taking into account the severity of the disease.
For the treatment of uncomplicated gonorrhea, a single use of 400 mg per day is indicated. The duration of therapy depends on the type of infection and the nature of the course of the disease. After the disappearance of symptoms, therapy is continued for about 3 days. This is necessary to obtain the greatest therapeutic effect.
So it is said in the instructions for the tablets "Cefixime".
In order to treat diseases of the ENT organs and respiratory tract of infectious etiology, medication is indicated for up to two weeks.
For the treatment of uncomplicated urinary tract infections in women, the use of the drug in a standard dosage for a week is indicated. If the upper parts of the urinary tract have been infected, the use of the drug is extended to two weeks.
If the patient has impaired renal function, then the dosage should be determined taking into account the creatinine clearance in the blood.
If the clearance is at the level of 21-60 ml / min, or the patient is undergoing hemodialysis, the drug should be used in other pharmacological forms.
The daily dosage of the drug is reduced by approximately 25%. If creatinine is at a level of less than 20 ml / min, then the dosage of Cefixime should be halved. The same rule should be observed when treating patients undergoing peritoneal dialysis.
Overdose
The instructions to Cefixime should be strictly observed.
Against the background of the use of the drug, patients may develop various undesirable reactions, which become more pronounced if an overdose of the drug occurs.
To stop the symptoms of overdose, the patient should immediately carry out a gastric lavage procedure and prescribe symptomatic and supportive therapy.
The patient is recommended to start taking glucocorticoids and antihistamines, to carry out oxygen therapy.
A specific antidote to medicine is not known.
Adverse effects
Against the background of application according to the instructions of "Cefixime" 400 mg, various negative reactions are able to develop. Adverse reactions that occur when using the medication are most often minor and weakly expressed. Among them:
- Hair loss.
- Fungal dermatitis.
- Dry skin.
- Increased perspiration.
- Epidermal necrolysis of a toxic nature.
- A variety of rashes on the skin.
- Arthralgia.
- Hypoprothrombinemia.
- Serum sickness.
- Thrombophlebitis.
- Purpura.
- Hemolytic anemia.
- Hives.
- Agranulocytosis.
- Cholestasis.
- Increased prothrombin time.
- Erythrem multiforme.
- Increased thrombin time.
- Anaphylactic shock.
- An increase in the level of transient phosphatase in the blood.
- An increase in transaminase levels in the blood of a transient nature.
- Leukopenia
- Increased levels of creatinine and urea.
- Fast fatiguability.
- Interstitial nephritis.
- Stomatitis.
- General weakness.
- Impaired renal function.
- Pain in the head.
- Dizziness.
- Dyspeptic manifestations.
- Decrease in appetite.
- Pseudomembranous colitis.
- Diarrhea.
- Candidiasis of the mucous membranes.
- Abdominal pain due to spasms in the intestine.
- Glossitis.
- Flatulence.
- Dry mucous membranes in the oral cavity.
- Icterus sclera.
- Hyperbilirubinemia.
- Vomiting
- Nausea.
If you experience these unwanted effects of the drug, consult your doctor.
Analogs
Currently, there are many means, the action of which is similar to Cefixime. The most popular and often used are: Ceforal, Cefix, Cefic, Cefigo, Flamifix, Fixim, Fix, Suprax, Sortsef, Maxibat, Lopralax , Inzim, Vinex, Efmerin, Efektal, Emsef, Ceftriaxone, Ceftrax, Cefotriz, Cefolight, Cefodar, Cefogram, Cefgreen, Trimek ”,“ Cefast ”,“ Tercef ”,“ Rumixon ”,“ Rotacef ”,“ Protsef ”,“ Ratsiotsef ”,“ Promotsef ”,“ Oframax ”,“ Norakson ”,“ Partsef ”,“ Medaxon ”,“ Maxson ” , “Loraxon”, “Lenlaci”, “Diaceph”, “Denicef”, “Bresec”, “Blicef”, “Belcef”, “Auroxon”, “Alzizon”, “A Cabo "," Avekson ".
Some of these drugs are in tablet form only, others are available in capsule or powder form.
Cefix
Cefix in any form of release, including in the form of a suspension for children, has high stability to the presence of beta-lactamases, enzymes that fight beta-lactam antibiotics. As a result, many microorganisms resistant to penicillins and cephalosporins become susceptible to the effects of the active substances of the drug.
It is prescribed for the treatment of the following pathologies:
- acute intestinal diseases;
- uncomplicated urinary tract infections;
- otitis media.
Also, the drug is effective for pharyngitis, laryngitis, pneumonia.
Noraxon
It is an antibacterial drug for systemic use, its main active substance is ceftriaxone sodium. Included in the group of beta-lactam antibiotics, this is the 3rd generation cephalosporin. It has a prolonged effect, it is used exclusively parenterally (bypassing the gastrointestinal tract). It treats infections whose pathogens are sensitive to ceftriaxone.
If it is necessary to replace Cefixime with a similar medication, it is important to consult a doctor so that he determines the feasibility of such a replacement.
Cost
The cost of the drug in Russian pharmacies depends on its pharmacological form and dosage. So, the average cost of a medication with a dosage of 200 mg will be about 450 rubles. It will cost an average of 760 rubles a pack of 400 mg Cefixim tablets. The instructions for use do not contain such information.
The price of the drug is not very affordable, but the drug has a lot of analogues that are much cheaper.
Reviews
Most of the encountered reviews about the experience of therapy with the use of Cefixime are positive. The drug is quite highly evaluated not only by patients, but also by doctors.
The availability of the drug, the possibility of its use in the treatment of children, a rather pleasant taste, almost complete absence of negative effects (which develop, as a rule, after the first use, and then completely disappear), high efficiency and a wide range of indications are separately noted.
Are there any disadvantages of the drug?
The main disadvantages of the drug are: a fairly short shelf life, an extensive range of possible negative reactions, high cost.
Despite the presence of negative characteristics, most patients recommend it as an effective medication.
We reviewed the instructions for use with Cefixim tablets.