"Omez D" is a capsule-type drug that combines two active components - domperidone and omeprozole, against the background of which the production of gastric juice decreases, an antiemetic effect develops with reflux disease and gastrointestinal dyspeptic manifestations.
Read more about the active components of the drug
Omeprazole is a representative of a group of pharmacological substances that can inhibit a proton pump in the lining of gastric cells. As a result, the secretion of hydrochloric acid is blocked, the acidity of the secreted gastric juice decreases.
Domperidone does not affect the synthesis of hydrochloric acid. The presence of this substance in the composition of Omeza D is due to its ability to act on the cardiac sphincter, increasing its tone. The result of this effect is the acceleration of the process of emptying the stomach.
The mechanism of action of the drug
The mechanism of action of domperidone is that it blocks the dopamine receptors of the second type, thereby eliminating the inhibitory effect of dopamine on the functionality of the gastrointestinal tract. Against the background of the use of domperidone:
- The duration of contractions of the duodenum and antrum in the stomach increases.
- The gastric emptying is accelerated, the influence of the gastric juice and the likelihood of its reflux into the esophagus are reduced.
- The tone of the esophageal cardiac sphincter rises.
- Prevention of nausea and urge to vomit.
According to the instructions for Omez D, the antiemetic effect of domperidone is due to a combination of antagonistic action in relation to the trigger receptors of the vomiting center located in the brain and stimulation of the stomach. In addition, domperidone is able to increase the content of prolactin in the blood serum.
From pharmacies, medication is dispensed exclusively if there is a prescription form from a doctor.
Pharmacological properties, composition of the drug
As indicated by the instructions for use with Omez D, the manufacturer produces the drug in the form of capsules made from gelatin. They have a white body, the lid is light purple. Each capsule has an inscription with the name of the drug. Content is represented by pellets, particles, white powder. The medicine is produced by an Indian pharmaceutical company.
Indications for use
The drug is recommended for patients in the treatment of reflux disease and dyspeptic disorders, if monopreparations, which are proton pump inhibitors or antihistamine receptor antagonists, do not have the desired effect.
The use of "Omeza D" is strictly prohibited for patients with the following physiological or pathological conditions:
- Individual hypersensitivity to any of the components present in the composition of the drug.
- Childhood.
- The lactation period.
- Pituitary tumor of hormone-secreting type.
- Perforation in the intestines or stomach.
- Digestive obstruction of a mechanical nature.
- Bleeding in the intestines or stomach.
It is important to exercise caution when using the drug if the patient has renal, hepatic dysfunction. Also, precautions when using the product should be followed by pregnant women.
This is confirmed by the instruction to "Omez D". Reviews about the drug are abundant.
Using
Capsules are intended for oral administration. It is recommended that adult patients take 1 capsule twice daily, and should be taken 20 minutes before meals.
Negative impact
Against the background of the use of "Omeza D", like any other medication, various negative reactions can develop. The drug has a distinctive characteristic - due to the presence of two active components in it, patients may develop negative effects characteristic of each of these substances.
During domperidone therapy, the following reactions are not ruled out:
- Gastrointestinal tract: intestinal upset, improvement or deterioration of appetite, heartburn, thirst, stomatitis, dry mouth, spasms of smooth muscle structures.
- Nervous system and visual analyzer: itching in the eyes, inflammation of the eyes, cramps in the lower extremities, increased nervousness, headache, asthenic syndrome, extrapyramidal disorders.
- Allergic in nature: swelling of the extremities, face, urticaria, itching, rash.
- Of a different nature: tachycardia, urination disorder, irregular menstruation, enlargement of the mammary glands, pain in the mammary glands.
Under the influence of omeprazole, the following negative symptoms may develop:
- Gastrointestinal tract: hepatitis, increased activity of hepatic transaminases, atrophic gastritis, the appearance of gastric polyps, candidiasis, stomatitis, taste disturbance, intestinal upset, abdominal pain, flatulence, vomiting, decreased appetite, nausea, dry mucous membranes in the oral cavity.
- NS and visual analyzer: visual impairment, encephalopathy, hallucinations, mental disorders, depressive states, increased nervousness, insomnia, dizziness, asthenic syndrome, malaise, headache.
- Musculoskeletal system: muscle weakness and pain, joint pain.
- Circulatory system: anemia, leukocytosis, a decrease in the number of eosinophils, leukocytes, platelets, neutrophils.
- Urine excretion system: urinary tract infection, swelling, protein and blood in the urine.
- Subcutaneous tissue and dermis: baldness, erythrem, photosensitivity.
- Allergic reactions: anaphylaxis, nephritis, angioedema, bronchospasm, itching, urticaria, rashes.
- Manifestations of a different type: gynecomastia, chest pain, hyperhidrosis.
If any of these negative symptoms develops, you need to consult a doctor, you probably need a dose adjustment or a complete withdrawal of the drug.
Interaction with other medicines, special instructions for use
The bioavailability of domperidone is reduced when it is used concomitantly with sodium bicarbonate, cimetidine, and other secretolytics and antacids.
When combined with anticholinergics, neutralization of domperidone is noted.
The level of domperidone in the blood increases with the combination of omeza D with nefazodone, HIV protease inhibitors, macrolides, and antimycotic agents of the azolone series.
Omeprazole is able to increase the pH in the stomach, so when combined with ketoconazole, itracosole, iron-containing medications, ampicillins, esters, their absorption is reduced.
Omeprazole is able to reduce the secretion of phenytoin, indirect anticoagulants, and diazepam. Therefore, their dose should be adjusted by a specialist.
Against the background of the use of Omeza D, according to reviews, it is possible that the effect of drugs that inhibit hematopoiesis is enhanced.
Before starting therapy, it is necessary to exclude the presence of neoplastic processes in the digestive tract of the patient.
Analogs "Omeza D"
The drug has no direct analogues, however, if necessary, it can be replaced by a combination of medications containing omeprazole and domperidone. Among the preparations containing domperidone, the most popular are:
- "Domet." It is produced by the Indian manufacturer in tablet form.
- Domperidone. Domestic drug in the form of tablets.
- "Domperidone HEXAL." It is made in the Netherlands.
- "Domperidon-Teva" Tablet medicine of Israeli production.
- "Motizhect." Tableted means of domestic production.
- Motilak. It has two pharmacological forms - oral tablets and tablets intended for resorption. Produced by a domestic pharmaceutical company.
- Motilium. Has a French origin, is available in the form of tablets intended for resorption, oral tablets, suspensions.
- "Motinorm." The manufacturer comes in tablet and syrup form, is of Indian origin.
- "Motonium." The drug is based on domperidone of domestic origin, is available in oral tablets.
- Passasics. It is produced by a Russian pharmaceutical company, has two pharmacological forms - chewable and oral tablets.
Popular drugs with omeprazole
The most popular drugs that contain omeprazole are:
- "Zhelkizol". A medicine of Chinese origin.
- "Losek." Available in Sweden.
- Omeprazole Zentiva. The medicine is made in Slovakia.
- Omeprazole Sandoz. The drug is of Slovenian origin.
- "Omeprazole Stad." It is made at the Russian pharmaceutical factory.
- Omeprazole-OBL. It has a Russian origin.
- Omeprazole-Akrikhin. Also a domestic drug.
- Omeprazole Richter. The medication is available in Spain.
- Omeprazole-Teva. It is made in Israel.
- Omipix. It is a drug manufactured in India.
- Omitox. Indian drug.
- Orthanol. Available in Slovenia.
- "Pleom-20." It is made by the Indian company.
- "Promez." It is of Indian origin.
- "Romesek." It is of Indian origin.
- "Ulkozol". Argentinean drug.
- Ultop. It is made in Slovenia.
- "Helicide." It is of Czech origin.
- "Tsisagast". Available in the Czech Republic.
Cost
The average cost of a drug in Russian pharmacies is 330 rubles for a package containing thirty capsules. The price may fluctuate depending on the region of sale and the pricing policy of the pharmacy chain that distributes it.
Reviews about "Omese D"
Most of the responses about the experience of using the drug are positive. Patients note that the use of the drug improved their condition in peptic ulcers and other gastrointestinal pathologies. Separately, the ability of the drug to effectively eliminate constipation is noted.
Drug therapy is only in rare cases accompanied by the development of negative reactions, which, like the affordable cost, is an undoubted advantage of Omeza D.
However, patients should remember that self-medication can cause complications, so therapy should be prescribed by a doctor.
We have reviewed the instructions for use and reviews for the Omez D preparation.