"Indapamide Retard": instructions for use, reviews

The drug "Indapamide Retard", presented in almost any modern pharmacy, is available to the general public - the price of packaging starts at 30 rubles. Recommended for high blood pressure. The main active ingredient gave the name of the drug is indapamide. The substance has a pronounced diuretic effect, due to which it has established itself as reliable and effective.

general information

According to the instructions, in “Indapamide Retard” 1.5 mg of indapamide. In addition to the active compound, additional components are present in the preparation. The tool belongs to the group of long-acting medicines. The active substance is in the core of the capsule, the outer coating is a thin film shell of a specialized substance. This makes the use of tablets simple, convenient.

As an auxiliary, the manufacturer used the following substances in the manufacture of tablets “Indapamide Retard”:

• hypromellose;
• lactose;
• povidone;
• silicon dioxide;
• magnesium stearate;
• Opadra;
• titanium dioxide;
• talc.

Carefully study the composition should persons suffering from hypersensitivity, intolerance to any substances used in the pharmaceutical industry. In particular, the tablets in question are not suitable for persons who are prohibited from lactose.

In the instructions for use of "Indapamide Retard" 1.5 mg (dosage of the active compound), the manufacturer indicates that the tablets are round, convex on both sides. Shell - white or close to white (grayish, brownish). The surface is a little rough to the touch. If you cut the instance, you can see two layers. Inside there is a white substance (possibly close to white), and the shell is white or having a slight shade of gray, brownish.

Pharmacological features

"Indapamide Retard" belongs to the class of diuretics, has the effect of a vasodilator, therefore, allows you to normalize high blood pressure. The features of the effect on the human body are somewhat similar to the effects of thiazide diuretics to lower blood pressure. When taking the drug, excretion of chlorine, sodium from the body with urine increases. To a slightly lesser extent, the agent stimulates the leaching of potassium, magnesium ions. The active component selectively inhibits the work of slow calcium channels, which means the arterial vascular walls become more elastic, and resistance at the periphery of the circulatory system decreases.

The active component of the tablets “Indapamide Retard” allows you to slightly reduce left ventricular hypertrophy. When it is taken, the fat profile of the blood is not adjusted, the ratio of lipids in the plasma does not change. No effect on carbohydrate metabolism. Tests have shown the absence of such an effect even when taking the drug by people with diabetes.

Tests have shown that Indapamide Retard helps to reduce the sensitivity of blood vessels to a second angiotensin, norepinephrine. The formation of several types of prostaglandins is activated. Under the influence of indapamide, the production of oxygen radicals (stable, free) is inhibited.

Patients note a long and pronounced effect from taking the pills - many reviews have been devoted to this. Instructions for use "Indapamide Retard" confirms that the tool affects the pressure during the day after taking the medicine. Against the background of the presence of indapamide, urination is moderately activated in the body.

Kinetics

Soon after taking the tablets, the active ingredient is absorbed. The processes are localized in the digestive tract. Bioavailability is estimated at 93%. It was revealed that the use of “Indapamide Retard” during a meal slows down the absorption process. The presence of food in the digestive tract does not affect the quality of the absorption process.

The highest levels of active compounds in blood plasma are achievable on average 12 hours after taking the pill. With repeated use, fluctuations in indicators reflecting the amount of the active drug in the intervals between the moments of use of the tablets are slightly reduced. The manufacturer in the instructions to "Indapamide Retard" (1.5 mg - the content of indapamide in one tablet) notes that stable levels of the active substance in the circulatory system are on average achievable a week after the start of taking the drug. This applies only to regular use. It is advisable to take the tablets every day at a stable, same time.

The elimination half-life is estimated at an average of 18 hours. In the instructions for use of Indapamide Retard, the manufacturer draws attention to the fact that about 79% of the active substance, when it enters the circulatory system, enters into strong bonds with protein structures. Possible reaction with muscle elastin present in the walls of blood vessels. The drug has a high volume of distribution. Indapamide is able to pass through organic barriers in the human body, including the placenta. Studies have shown that the active substance passes into breast milk.

Instructions for use "Indapamide Retard" mentions that metabolic processes are localized in the liver. Up to 80% of reaction products are excreted from urine, about 5% of indapamide do not change. The elimination route of other volumes is the intestinal tract. With insufficient kidney function, there is no change in the kinetics of the component. No cumulative effect was found.

It is possible and impossible

In the instructions for use of "Indapamide Retard" (1.5 mg), the manufacturer indicates that the product is intended for use by persons suffering from hypertension (high blood pressure). You can use the medicine strictly in agreement with the doctor. According to the rules, the drug is dispensed from pharmacies upon presentation of a prescription by the attending physician.

It is forbidden to use the tool if any conditions, individual characteristics inherent to a potential buyer, can provoke a severe negative response of the body. All cases in which the use of tablets is dangerous are listed by the manufacturer in the accompanying documentation.

Contraindications mentioned in the Indapamide Retard instructions:

• hypersensitivity or intolerance to indapamide or any other substance used in the manufacture of the drug;
• high sensitivity, allergic reaction to products obtained from the processing of sulfonamide;
• failure of the kidneys, liver in severe form;
• anuria
• lack of potassium in the circulatory system;
• encephalopathy;
• lack of lactase;
• lactose intolerance;
• malabsorption syndrome.

The manufacturer indicates the impossibility of using the medication in a minor age. In the instructions to the “Indapamide Retard” it is mentioned that no special studies have been conducted to identify the effectiveness of the drug in this group of patients, its safety.

Special occasion

As can be seen from the reviews, “Indapamide Retard” (1.5 mg) is sometimes prescribed to people suffering from impaired liver and kidney function. Patients with these features of the condition note that doctors, recommending taking pills, immediately indicate possible side effects from taking them, and also instruct how to respond to them, at which response the body needs to stop using the medication.

Restrictions on the possibility of using the remedy are imposed by:

• violation in the circulatory system of the ratio of water and electrolytes;
• decompensated diabetes mellitus;
• increased uricemia;
• hyperparathyroidism.

Particularly noteworthy are people suffering from gout, as well as people who have identified urate nephrolithiasis.

Certain restrictions are imposed by drug therapy. The combination of Indapamide Retard (1.5 mg) and agents capable of lengthening the QT interval requires maximum accuracy.

Mother and child

According to reviews, Indapamide Retard (1.5 mg) is not used during pregnancy. Women who took these pills noted: when a fact of conception was detected, they had to refuse therapy at the doctor’s insistence. This is due to the risk of ischemia. Against the background of the use of the medication, there is a likelihood of a delayed development of the embryo.

During lactation, the tablets “Indapamide Retard” are not recommended, since the active component is able to penetrate into milk. If it is not possible to avoid taking the drug at this time, you should transfer the child to artificial nutrition.

Terms of use

The manufacturer recommends taking the tablets orally. Chewing is not required. Patients who took the drug noted that the consumption process was not particularly difficult, but for some it was difficult to maintain the stability of the time of administration.

In reviews of the Indapamide Retard, patients using the tablets mentioned that they drank one capsule of the drug per day. The same dosage is recommended by the manufacturer in the accompanying documentation. In a particular case, some adjustment is possible based on the individual characteristics of the situation - the doctor will give recommendations.

Standard dosage regimen: one capsule in the morning, daily at the same time. "Indapamide Retard" abundantly washed down with clean boiled water without additives.

Negative consequences

Although observations of those taking the pills showed that in most cases the medication is well tolerated, there are references to various unpleasant effects in the reviews of Indapamide Retard that occurred while using the medication. Not all patients complained about them - many admit that they did not encounter any side effects at all. The manufacturer in the accompanying documentation for the tablets indicates that the use is associated with a risk of the following reactions:

• nausea, weight loss, upset stools, epigastric pain, liver encephalopathy, pancreatitis, dry mucous membranes, hepatitis;
• asthenia, agitation, pain and dizziness, sleep disturbances, depression, weakness, muscle cramps, anxiety, tension and nervousness;
• cough, inflammatory processes in the throat, nasal cavity;
• violation of rhythm and speed, severity of the heartbeat, a sharp decrease in pressure;
• kidney infection, failure of the work of this body;
• allergic reactions, including pruritus, urticaria, necrolysis;
• thrombocytosis, leukopenia, anemia, agranulocytosis.

Taking pills on the background of lupus erythematosus can cause an exacerbation of this pathological condition. Isolated cases of increased sensitivity to light are known. It is possible to change laboratory parameters when receiving samples from the patient for research. "Indapamide Retard" can cause a lack of potassium, sodium, chlorine in the blood, excess calcium, nitrous urea, creatinine. Possible detection of glucose in urine.

Too much!

When using the medicine in excess of the established limits, the following conditions are possible:

• pressure reduction;
• violation of the balance of water and electrolytes;
• nausea and vomiting;
• seizure
• craving for sleep;
• slowness of reactions;
• confusion of consciousness;
• anuria

Inhibition of respiratory function is possible. With cirrhosis, there is a risk of liver coma.

If an overdose is detected, the patient is shown gastric lavage and sorbent intake. The doctor prescribes funds to correct the balance of electrolytes, drugs to relieve other symptoms. The antidote indapamide does not have.

The nuances of using

Often, patients who have been prescribed the described drug are interested in how "Indapamide" and "Indapamide Retard" differ, what is the difference between them. Both products are based on the same active component, but the specifics of the composition are such that the drug with the prefix “Retard” in the name has a longer lasting effect. This tool provides an effect on pressure within 24 hours due to the gradual release of the active component. This approach to the creation of funds has allowed to reduce the concentration of the main substance. This is another of the points that distinguishes Indapamide from Indapamide Retard. The first is available with the content of indapamide in one capsule of 1.5-2.5 mg, the second is in only one form - 1.5 mg.

The doctor should choose which option to use in a particular case. Doctors know better the average people than the difference between “Indapamide” and “Indapamide Retard”, which means they can analyze which form to recommend to a particular patient. Choosing the best option is the key to effectiveness while minimizing the likelihood of side effects.

There is no universal answer to the question of which is better: - “Indapamide” or “Indapamide Retard”. Mostly the instructions for using these two medicines are the same. They are based on the same active compound, there are no differences in the indications, contraindications. The rules of use do not differ. The doctor chooses for the patient which is better (Indapamide or Indapamide Retard). Take into account the financial aspect: usually, “Indapamide” costs a little cheaper than extended-release tablets. However, only saving is not enough reason to replace the drug prescribed by the doctor with another. The analog of Indapamide Retard (Indapamide) is at least slightly cheaper, but the difference is too small to take into account. If the doctor says that for the patient there is no difference what exactly to take, then you can take any of the medications.

What to replace: analogues

Instructions for use "Indapamide Retard" draws attention: the product is based on indapamide. The following drugs were created on the same compound:

• "Ravel."
• Indap.
• Arifon.
• Arifon Retard.

To some extent, they are all substitutes for the described composition.

If it is not possible to purchase the drug recommended by the doctor, the question of replacement is preliminarily agreed with the attending physician. Quite often, doctors are advised to stay at the Arifon Retard. Indapamide is an active component of this drug, in many of its parameters similar to the one under consideration. However, an important difference for many is the cost of the product. If the medication described above in pharmacies on average costs from 30 to 150 rubles, then the price for packing a popular analogue exceeds 300 rubles.

One cannot say for sure which is better - “Indapamide” or “Arifon Retard”. The first tool is produced by several companies, has an affordable price. The second drug is a French development. It was he who first appeared on the market. The name of the drug is patented, and the right to make it belongs to Servier. Since medicines for high blood pressure have to be used for long courses, a foreign product is not available to everyone. If necessary, save should be clarified with the attending physician, for a particular patient what is better - "Arifon Retard" or "Indapamide". If the doctor confirms that the effect is equal, and the likelihood of side effects is the same, the patient can choose the product that fits better into the family budget.

Indapamide Retard: Compatibility

The manufacturer of tablets for high blood pressure recommends avoiding the combination of the drug and lithium products. Such a combination can cause an increase in the concentration of lithium ions in the blood plasma, a decrease in the excretion of these compounds by the kidneys, and therefore there is a likelihood of a neurotoxic effect.

Studies have shown that "Indapamide Retard" is combined with agents that can provoke a disturbance in the rhythm of the heartbeat, but such combination therapy requires special attention to the patient. With certain deviations (the doctor will explain in a particular case which ones), the therapeutic course will have to be interrupted. A combination of indapamide and is associated with risk:

• funds for arrhythmias from category IA;
• third class drugs against arrhythmia;
• phenothiazines;
• sotalol;
• benzamides;
• butyrophenones.

There is a risk of ventricular arrhythmias with a combination of indapamide and intravenous injection:

• erythromycin;
• vinkina.

Certain dangers are associated with the simultaneous use of the drug in question for pressure and pentamidine, moxifloxacin, astemizole, halofantrine, bibridyl.

It is necessary to warn the doctor about ongoing drug therapy, all the drugs that the patient is taking. This will reduce the risk of negative interaction. The doctor will explain how the mutual influence of funds on each other can manifest itself, give instructions on how to behave in such a situation.

During the course, it is recommended to regularly check the patient's condition, detect the concentration of electrolytes in the circulatory system, and take an ECG. If a potassium deficiency is detected, drug therapy will have to be adjusted to avoid arrhythmias.

Attention to all the details

The combination of Indapamide Retard tablets and non-hormonal drugs for stopping inflammatory processes (including acetylsalicylic acid, selectively inhibiting COX-2 drugs) can cause a decrease in the effectiveness of indapamide.Against the background of dehydration, there is a risk of kidney failure in the acute form, since the activity of glomerular filtration will decrease. Risks apply only to situations where non-steroidal anti-inflammatory drugs are used systemically. Starting such a therapeutic course, you should first check the electrolyte content in the circulatory system, adjust the level to normal. While taking the drug, you need to regularly take tests to clarify the quality of the kidneys.

The combination of Indapamide Retard medication and ACE inhibitory drugs with a low concentration of sodium in the circulatory system, stenosis of the artery that feeds the kidneys may be accompanied by arterial hypotension. For patients undergoing such a course, the risk of acute kidney failure is assessed above average.

With arterial hypertension and a suspicion of a lack of sodium in the body due to the use of diuretic foams, it is reasonable to stop using the Indapamide Retard tablets three days before the start of the IPAF course. You should start using diuretics that do not correct the level of potassium in the blood. An alternative is the use of IPAF at the beginning of the course at the lowest possible dose. Gradually increase the volume, if necessary. The first week of such a program should regularly take fluid samples to control creatinine clearance.

Important subtleties of reception

If the patient is prescribed cardiac glycosides, if the patient is taking a course of laxatives, taking "Indapamide Retard" requires checking the concentration of potassium ions in the blood, creatinine clearance indicators. Such measures are also necessary when taking a diuretic by elderly people and people suffering from hyperaldosteronism.

It is especially important to monitor the condition of patients taking diuretics to lower blood pressure if cirrhosis is detected. If the situation is complicated by ascites, puffiness, a high probability of metabolic alkalosis. Encephalopathy of the liver in such conditions is much more pronounced, so the patient's condition may worsen. Control is also required when taking pressure medications for people suffering from cardiac ischemia, heart failure.

Increased risks are associated with the use of indapamide tablets by individuals who are characterized by an excess of the long QT interval. This applies equally to those who have a congenital deviation, and to cases of acquired disorders due to pathologies.

In diabetes, it is important to monitor the concentration of glucose in the circulatory system. Persons suffering from a lack of potassium in the blood should be especially attentive to their health.

Severe dehydration can cause acute kidney failure.

At the beginning of the course, it is important to constantly take tests to monitor renal function. The doctor will explain how to replenish blood volumes (BCC). With gout, there is a risk of activation, an increase in seizures of the disease.

At the doping control, there is the likelihood of a positive response against the use of indapamide.

The manufacturer indicates the need to be especially careful when driving, if a person takes Indapamide Retard tablets. This applies to work with high-precision mechanisms, equipment. At the same time, there is no absolute ban on such activity.

What's in pharmacies?

"Indapamide Retard" is available in tablet form. Capsules are packaged in blisters. One blister contains 10-15 tablets (depending on the form of release). In a cardboard box, the manufacturer places the instructions for use and three blisters for 10 capsules or two for 15. On the outside are the name of the medication, manufacturer, expiration date and production date, rules for dispensing the drug, the exact number of tablets inside.

It is unacceptable to use "Indapamide Retard" after the expiration date. The product should be stored in a dark room at temperatures up to 25 degrees. If the storage conditions are violated, the medication should not be eaten. Choosing a place to store it is necessary where children do not have access.

How it will help: arterial hypertension

"Indapamide Retard" is prescribed for high blood pressure. It is customary to talk about a pathological condition when the pressure value is steadily maintained above 140/90. In rare cases, such parameters are normal for a person and are explained by individual characteristics - then special adjustment is not required. If the condition brings discomfort, treatment is necessary. At present, arterial hypertension is one of the most common health problems if we analyze the diagnoses of patients all over the planet. The older the person, the higher the likelihood of such failures.

Sometimes hypertension is an independent disease, but there are cases of its development against the background of other health disorders. Improperly functioning adrenal glands, kidneys, and neoplasms can provoke high blood pressure. Often, pressure is provoked by experiences, stresses, although other causes are possible. As a rule, a health disorder develops gradually. First, the pressure rises occasionally and insignificantly. If this is just a response to an external factor, then it is too early to talk about pathology. When the pressure becomes elevated persistently, hypertension is diagnosed.

How to notice?

The most significant manifestation of hypertension is pressure above 140/90. You can check the indicators yourself at home if you purchase a tonometer.

"Flies" appearing in front of the eyes may indicate increased pressure. Sometimes dizzy and sore head, impaired vision. As a rule, the progress of the disease is associated with malfunctions of the functionality of various internal organs. Persons suffering from high blood pressure are characterized by swelling, suffocation and shortness of breath are possible. Symptoms sometimes appear suggesting heart failure.

It is accepted to distinguish three main degrees of hypertension. If the indicators vary within 159/99, they talk about the first degree. The progress is indicated by raising the parameters to 179/109. With a third degree, pressure is higher than 180/110.

An isolated increase in systole only is possible when the first parameter exceeds 149, and diastole varies within 90.

There are several reasons for this condition. If the disease is primary, in most cases it does not seem realistic to determine why the pathology has developed. It is known that it is more likely to encounter high hypertension if there are hypertensive patients among close relatives. AH is more often observed in people older than 50 years of age, as well as in people who have bad habits, primarily smoking. Hypertension can provoke low mobility in everyday life, excessive intake of salt, endocrine diseases, diabetes mellitus, and frequent effects of stress factors.

Secondary hypertension is often observed in diseases of the kidneys, blood vessels that feed these organs, adrenal glands. High likelihood of high pressure in tumor processes and impaired blood dynamics. Vascular lesions that cause hypertension are divided into congenital and acquired. Both types can equally provoke pressure above normal. Another possible cause is obstructive sleep apnea. Sometimes hypertension is caused by taking medications (more often - hormonal or lowering the temperature).