Medication "Indapamide" acts on the vascular walls, relaxing them and normalizing the elasticity of the muscles. Thanks to this drug, arterioles increase, which leads to unhindered blood movement in the body. Pills "Indapamide" - a cure for pressure. This is a vasodilator, pharmacodynamically similar to a thiazide diuretic. During the day, the amount of urine produced increases slightly. Together with it, the prevailing sodium ions, chlorine, and potassium are removed from the body. While taking the medicine, carbohydrate and fat metabolism remain normal, which makes it possible to take the drug for patients with obesity or diabetes. With a marked increase in the left ventricle of the heart , Indapamide significantly reduces the level of hypertrophy. With regular use of the drug, the effect is achieved after 2 weeks, and after 10 weeks the maximum beneficial effect is noted. A single dose of the drug "Indapamide" retains its therapeutic property for up to 24 hours.
Pharmacokinetics
The drug from pressure "Indapamide" is rapidly absorbed in the gastrointestinal tract and excreted mainly in the urine. The content of inactive metabolites in feces is about 20%. Diuretic interacts with plasma and red blood cells, passes into breast milk. With regular use of the drug, cumulation is not observed. Patients with liver failure should use this medicine with caution in order to avoid the formation of liver encephalopathy.
Indications for use
What does the medicine "Indapamide" help? Indications for its use are:
- Arterial hypertension.
- Chronic heart failure (sodium and water retention in the body).
Contraindications
Taking the drug is limited in the following diseases:
- Impaired liver function.
- Impaired renal function.
- Intolerance to the components of the drug.
- Hypokalemia.
- Circulatory disorders in the system of the brain and spinal cord.
- Gout.
In what cases may complications arise with the use of the medication "Indapamide"
From what it is recommended to take this drug, we have already found out. But when do you need to be especially careful when using it? Such cases include:
- Lactose intolerance.
- Pregnancy and lactation.
- Age to 18 years.
- Unstable water-electrolyte balance.
Method of application, dosage
The drug is taken orally 1 time per day at 2.5 mg. Morning intake is more effective because a large amount of food slows down the absorption of the drug. The tablets should be swallowed without chewing, drinking plenty of water. An increase in the dose of Indapamide does not accelerate the therapeutic effect, but causes a number of side effects. Patients suffering from heart failure, in the absence of improvements, are prescribed a dose of 5 mg per day.
Adverse reactions
When taking the drug "Indapamide" (from which it is prescribed, we already know), a side effect may occur. First of all, this happens when using an increased dose of the drug, intolerance to the substance by the body, the impact of individual components on a specific organ system. Side effects can occur in different ways.
- Central nervous system: headache, drowsiness, asthenia, insomnia, irritability.
- Respiratory system: pharyngitis, acute cough.
- Digestive system: nausea, vomiting, diarrhea.
- Urinary system: nocturia, infectious inflammation.
- Cardiovascular system: arrhythmia, palpitations, hypokalemia.
- Skin diseases: itching, urticaria, rash.
Cost
The average price of Indapamide in Russia is 12 rubles. In the package of 30 tablets of 2.5 mg.
Interaction with other drugs
Anti-inflammatory drugs reduce the effect of the drug "Indapamide", quickly spend fluid in the body, because of which it has to be constantly replenished. When taking Indapamide tablets, what does compatibility with other drugs depend on? The composition of the diuretic is quite complicated, so the complex treatment is selected by a specialist strictly individually, based on the prescribed drugs.
- Preparations containing lithium are quickly excreted in the urine, so it is necessary to control the level of the substance in the blood serum.
- GCS, on the contrary, retain water in the body, reducing the antihypertensive effect.
- Cardiac glycosides reduce the amount of potassium in the body, which can lead to hypokalemia.
- Calcium: an increase in salt levels in the body.
- Radiopaque preparations containing a significant amount of iodine can lead to the development of renal failure.
- Tricyclic antidepressants cause the risk of orthostatic hypotension.
special instructions
Which patients need close monitoring when taking Indapamide? What do they need to watch out for? Patients with cirrhosis of the liver, heart, kidney, liver failure are required to undergo treatment with Indapamide strictly under the supervision of doctors. The possible occurrence of dehydration in the body leads to an exacerbation of organ dysfunction. It is important to control the fluid content in the body and compensate for it in time.