What is Dimexidum for? We will understand in this article.
The drug is a synthetic drug for external use, which has analgesic, antibacterial and anti-inflammatory effects. This medication is widely used in dermatological medical practice, and is also prescribed for muscle and joint pain.
Reviews about "Dimexidum" are abundant.
Description
The main active substance of solutions of various concentrations for external use has a number of therapeutic effects:
- Anti-inflammatory effect - elimination of the severity of some manifestations of inflammatory processes, in particular, pain, swelling of the tissues and hyperemia (redness due to excessive blood supply).
- Local anesthetic effect - a decrease in all varieties of sensitivity (mainly pain) due to blockage of nerve endings located in the tissues.
- Antiseptic effect - suppression of various pathogenic (pathogenic) microorganisms - viruses, bacteria and fungi.
- Fibrinolytic effect - the dissolution of fibrin plaque in the area of damage to the skin or inflammatory process, which prevents the regeneration (healing) of tissues.
Dimexide is used in cosmetology.
Through local application, the active substance quickly penetrates into the mucous membranes and under the skin into deep tissues. In addition, it significantly increases their permeability to other medicines, therefore, solutions in most cases are used in combination with other medical preparations, having previously dissolved them in it.
What is the composition of "Dimexidum"?
Composition and form of release
The active substance of this medical product is dimethyl sulfoxide, auxiliary elements are nipagin (methyl parahydroxybenzoate), nipazole (propyl parahydroxybenzoate), sodium carboxymethyl cellulose (sodium carmellose), purified water. The composition of "Dimexidum" is described in detail in the instructions.
The drug is available in the form of concentrates for the preparation of solutions and gel for external use, in aluminum tubes, packed in cardboard packs. There are no other forms of release of Dimexidum.
Pharmacological properties
Medication with anti-inflammatory and local analgesic effects. It has a moderate antiseptic property, has a fibrinolytic effect.
Dimethyl sulfoxide is the main substance that suppresses inflammatory tissue infiltration, helps stabilize the process of fibrin formation, increases microcirculation in tissues, stimulates the aggregation of red blood cells, increases the activity of phagocytes, reduces the chemotaxis of neutrophils and the content of immune complexes circulating in the blood.
This active substance is able to penetrate through the layers of the skin, mucous membranes, the cell walls of bacteria (increases their sensitivity to antibiotics) and other biological membranes, and increases their permeability to medications. This medicine is practically non-toxic.
Pharmacokinetics
According to the instructions for Dimexidum, when a medication is applied, dimethyl sulfoxide is detected in the blood after about 7-16 minutes, and the maximum concentration of the substance is noted after 3-9 hours. As a rule, after 30-36 hours, dimethyl sulfoxide in the blood is no longer detected.
With external methods of using the drug, dimethyl sulfoxide penetrates the articular cavities, binds to proteins in tissues and blood, does not cumulate.
This active substance is excreted from the body through urine unchanged and in the form of oxidation products - dimethyl sulfate and dimethyl sulfone, as well as in the form of dimethyl sulfide (reduced product) is excreted with exhaled air.
Indications for use
The medicine "Dimexide" is prescribed in most cases as an element in the complex treatment of therapy of the following pathologies:
- Various disorders in the musculoskeletal system: rheumatoid arthritis, ankylosing spondylitis (ankylosing spondylitis), deforming osteoarthritis (with damage to periarticular tissues), reactive synovitis.
- Erythema nodosum, limited scleroderma, lupus erythematosus, foot mycosis, thrombophlebitis, keloid scars, eczema, alopecia, erysipelas.
- Sprains, bruises, traumatic infiltrates.
- Sciatica, trophic ulcers, furunculosis, purulent wounds, burns, acne.
What is Dimexidum for? The medicine is used, as a rule, to prevent a possible inflammatory process due to damage to the epidermis, or to eliminate an existing pathological focus.
In the field of plastic surgery, a drug can be used to preserve homotransplants.
Indications for the use of "Dimexidum" in gynecology
The medication is prescribed for:
- cervical erosion;
- complication after surgery;
- thrush;
- colpitis;
- cervicitis;
- vulvovaginitis;
- endometritis;
- adnexitis;
- condition after childbirth.
Contraindications
A pharmacological agent should not be used with the following pathological phenomena:
- hypersensitivity ;
- severe forms of hepatic or renal failure;
- angina pectoris;
- atherosclerosis;
- cataract, glaucoma;
- stroke, myocardial infarction, coma;
- pregnancy and lactation;
- children under 12 years old.
It is necessary to prescribe a medication simultaneously with other drugs with increased caution, since it can increase not only toxicity, but also the activity of some of them.
Dimexide Dosage and Administration
This medication is applied on the skin, in the form of compresses, irrigation (rinsing) and applications. How to use Dimexidum solution for compress?
In a solution of the drug of the required concentration, wet gauze wipes are applied and applied to the affected area for a duration of 20-30 minutes. A plastic wrap and cotton or linen cloth can be applied to such a napkin. The duration of the therapeutic course is 10-14 days.
In the treatment of trophic ulcers and erysipelas - apply a 30-50% solution of 50-100 ml several times a day.
With diffuse streptoderma and eczema, compresses with a 40-90% solution of the drug are used.
With local anesthesia for severe pain syndromes, a 25-50% solution in the form of compresses of 150 ml is used.
The medicinal product "Dimexide" in the form of a gel is used externally. It should be applied in a layer to the affected areas 1-2 times a day. The duration of such treatment should be 7-14 days. A second course can be carried out no earlier than 10 days.
How to use "Dimexide" in cosmetology?
For facial skin and other highly sensitive areas, it is recommended to use 10-20-30% solutions. You can make wrinkle masks with this tool. For these purposes, ointment and Dimexidum gel are usually used; a solution for such purposes is rarely used. For prevention purposes, the procedure is performed several times a month, and for skin problems 10-14 days 3 times a day.
In the field of plastic surgery, dressings with 10-20% solutions for transplanted skin homo- and autografts are used immediately after surgery and in the days following it until the graft is permanently implanted. A less concentrated solution of this medication rinses inflamed and purulent-necrotic cavities and foci.
Features of the use of "Dimexidum" in gynecology:
- Candles As a tool for complex treatment.
- Tampons. For this, sterile cotton wool will be needed, it is impregnated with a solution. Then, such tampons are inserted into the vagina. During menstruation, the drug is not recommended, since there is a likelihood of developing unwanted reactions.
- Compresses Lidase, novocaine, antibacterial agents, aloe can be additionally used. Pure tissue is wetted in the medicine, applied to the site of inflammation. Compress can cover diseased and healthy tissue.
- Electrophoresis The medication can also be used in physiotherapy. The therapeutic effect is enhanced, since the drug penetrates better into the tissues.
What else does the instruction to Dimexidum tell us?
Use in childhood
A medication is contraindicated for the treatment of children under 12 years of age, however, when patients reach this age, the medication is widely used not only to treat the above diseases, but also to eliminate coughs, which are inflammatory in nature. This symptom is so debilitating that it requires the use of emergency measures to eliminate it. In addition, irritation of the respiratory tract and throat causes pain during eating.
In this case, low-concentrated solutions of the drug "Dimexidum" in the form of compresses are used.
A similar remedy for treating a child acts as follows:
- relieves inflammation in the lymphoid tissue by the introduction of a drug substance in the immediate focus;
- enhances the properties of local immunity, stimulates the production of macrophages;
- actively promotes the introduction of medications that stop spasms of the respiratory system and have a direct anti-inflammatory effect, without introduction into the bloodstream and absorption in the body.
The medication does not have a warming effect.
This compress is given to children for 15-30 minutes, but no more. A gauze dressing can be applied not only to the throat with pharyngitis or laryngitis, but also to the chest with inflammation of the lungs and bronchi.
Side effects
According to reviews of "Dimexidum", when using a medication in some cases, the following negative reactions may occur:
- allergic - contact dermatitis, pruritic dermatitis, dry skin, erythematous rashes, mild burning, increased skin pigmentation, in rare cases - bronchospasm;
- digestive - nausea, vomiting.
With an overdose of this pharmacological drug, dose-dependent negative effects may be enhanced. In this case, the drug should be discontinued, rinse the damaged area and remove the solution.
special instructions
Some patients may experience a sensation of garlic odor in the inhaled air.
Before using the drug "Dimexidum" it is necessary to conduct a test for tolerance to it. To do this, a little solution should be applied to the surface of the skin with a swab moistened in it. The occurrence of severe hyperemia and itching will indicate hypersensitivity.
If allergic symptoms appear during treatment with this medication, it is discontinued and histamine H1 receptor blockers are taken.
Interaction with other medicines
The medicine is able to enhance the absorption processes and increase the effects of insulin, ethanol and other substances. Let's combine this drug with antibacterial drugs, heparin, and also NSAIDs.
In addition, during treatment with this agent, the sensitivity of microorganisms to beta-lactam and aminoglycoside antibiotics, as well as to chloramphenicol, griseofulvin, rifampicin, is enhanced.
Analogues of the drug
The following medicines are analogues of this medication for therapeutic effect:
- Apizartron;
- "Zhivokost";
- "Extra Hit";
- "Capsicum";
- Dolobene.
The composition of the absolute analogues of the drug "Dimexidum" are:
- "Dimethyl sulfoxide";
- "Dimex";
- Dimexid-Lugal;
- "Dimexide-JFF";
- Dimexidum FT.
Reviews about the drug
There are a lot of reviews about Dimexide, so we can conclude that this drug is used everywhere not only in the treatment of a variety of infectious and inflammatory pathologies, but also for prophylactic purposes with a high probability of developing purulent infections of damaged areas of the body. This medicine is used not only at home, but also in hospitals of hospitals and preventive departments.
In the reviews of patients who used Dimexidum solution for compress, a large amount of information about its high efficiency is reflected. First of all, this applies to a variety of purulent lesions of the skin resulting from injuries and bruises. At the same time, patients noted that after the start of therapy with Dimexidum medication in the form of purulent wound washing, their condition improved significantly - the affected tissues healed faster, the manifestations of redness, swelling and inflammation of the skin decreased. Also, this medicine has proven itself in the treatment of burns - patients observed rapid healing of the burn surface, a significant decrease in pain, which is especially pronounced with this pathology.
Leave feedback on "Dimexide" and people who used it to treat childhood diseases. They say that the medication effectively helps with a variety of pathologies of the throat and respiratory organs, which are inflammatory in nature. These are pharyngitis, bronchitis, tracheitis, pneumonia, rhinitis, etc. In this case, compresses were used with the drug in low concentrations, and parents claim that the disease in the child went much faster and easier.