Why does humanity need hormonal drugs? Hormones (from the Greek “induce”, “set in motion, excite”) are the product of the functioning of the endocrine glands. These substances manifest their influence distally, at different distances from the gland in which they formed. The effects of hormones are diverse and unique.
In the human body, a lot of different hormones are synthesized. Sometimes, against the background of various diseases, the activity of the endocrine system may decrease and, as a result, their (hormones) production decreases. To bring the situation to normal, hormonal drugs are needed. One of these is Prajisan. Reviews of patients and specialists characterize this substance as an excellent tool for the treatment of diseases of the female genital area.
Pharmacology
The drug is a corpus luteum hormone. With his direct participation, a change in the phase of the uterine mucosa occurs: from the state of proliferation, it passes into the secretory phase. Thus, “Prajisan” (reviews of doctors and information on the application instructions confirm this) creates optimal conditions for implantation of a fertilized egg into the mucosa.
In addition, under the influence of this hormone, the sensitivity of the uterus to such a substance as oxytocin decreases, its muscles relax. “Prajisan” helps to increase fat reserves, increase insulin levels (induced and basal), affects the efficient utilization of glucose, and stimulates the accumulation of glycogen in the liver.
Also, “Prazdisan” reviews has as a good tool that suppresses the synthesis of hypothalamic factors for the release of FSH, LH. In the tissues of the mammary gland, the hormone helps to reduce the permeability of capillaries, reduces the swelling of the connective tissue stroma.
In what cases is appointed?
All the most important and complete information about the hormonal drug "Prajisan" (capsules) contains instructions for use. Reviews, a description of the medication characterize it as very effective for problems such as secondary amenorrhea, infertility provoked by lutein deficiency, dysfunctional uterine bleeding, which are a consequence of a lack of progesterone.
Quite widely, “Prajisan” is used as a component of hormone replacement therapy in tandem with estrogenic drugs in the postmenopausal period. This hormone is also used to support the luteal phase in cases where additional reproductive techniques are used.
Ways to use the medication
In case of insufficient progesterone levels, Prajisana capsules are taken in a daily volume of 200-300 mg. The frequency of admission is twice a day. Determining the duration of the course of therapy is the prerogative of the doctor, everything is very individual and depends on the severity of the state of health.
The daily dose of the drug with luteal phase insufficiency can range from 200 to 400 mg. The duration of therapy is 10 days (strictly 17-26 days of the menstrual cycle).
During peri-and postmenopause, “Prajisan” (patient reviews state the drug is highly effective) is taken 200 mg per day in parallel with estrogens. The duration of the course is 10-12 days.
It is possible to use this hormonal agent at the stage of preparation for IVF in the form of capsules for vaginal administration. Duration of admission - until the onset of pregnancy.
When treating infertility, the cause of which is luteal insufficiency, the Prajisan gel is used. The duration of the course is 10 days.
When and who should refrain from using Prajisan?
As with any hormonal drug, there are contraindications for the Prajisan medication. Reviews, instructions for the use of this tool are prohibited in cases where the patient has such pathological problems as porphyria, vaginal bleeding of unknown origin, malignant neoplasms of the genital organs or mammary glands.
This medication is also contraindicated for those who suffer from thrombophlebitis, thrombosis and any other thromboembolic diseases. Do not prescribe "Prajisan" for acute cerebrovascular accidents and severe liver diseases.
Increased individual sensitivity to the main and auxiliary components of the medication is also a contraindication for taking the drug.
Pregnancy and Prajisan
A separate topic for discussion is “Prajisan” during pregnancy. Reviews of experts do not speak of persistent contraindications or indications. The fact is that a lack of progesterone in the body of a pregnant woman carries the threat of abortion. In such cases, the attending physician, as a rule, prescribes a course of appropriate therapy to enable the woman to safely endure the child. Prajisan is one of the possible options.
If the level of progesterone in the expectant mother is normal, then the woman will certainly put herself and the child at risk by taking the drug in the first half of pregnancy (16-18 weeks).
Also, one should not lose sight of the fact that taking “Prajisan” during pregnancy (expert reviews confirm this fact) during the period from 12 to 40 weeks of bearing a baby, the patient risks getting quite serious liver diseases.
Side effects
Patients taking "Prajisan" say about the presence of some side effects from different organs and systems. The cardiovascular system can respond by increasing blood pressure. From the side of metabolism, a pronounced reaction to Prajisan (expert reviews indicate this) is considered to be swelling. The digestive system is able to declare itself as a violation of the functioning of the liver, the development of jaundice. With prolonged use, nausea and vomiting may occur.
Also, when using Prajisan for a long time, a decrease in libido, weight gain, pain and a feeling of tension in the mammary glands, uterine bleeding (irregularly) are possible. A possible reaction of the central nervous system with prolonged use is depression, skin rash, itching, headaches. Quite often, patients talk about the appearance of a feeling of tiredness after taking the medication.