"Clomiphene citrate" is a synthetic non-steroidal drug, characterized in pharmacology as an antiestrogen. It is widely used both for medical purposes as a stimulator of ovulation in women, and in bodybuilding as a means for building muscle mass.
The action of the drug “Clomiphene” is based on its partial structural similarity with estrogen produced in the human body. Due to this, the main substance of the described agent can bind to estrogen hormone receptors, which stimulates an increase in the production of FSH and LH gonadotropins. And this, in turn, enhances the secretion of testosterone in men and estrogen in women.
Further in the article, we will describe in more detail the effect of the drug “Clomiphene” in various cases of its use.
How is the drug used in medicine?
The named tool is prescribed for men with androgen deficiency, with oligospermia and delayed sexual and physical development in adolescents.
The drug “Clomiphene citrate” is also popular in gynecology as a tool that can help a woman with diagnosed ovarian dysfunction, ranging from minor deviations to serious pathologies.
For women, this drug is indicated for uterine bleeding, post-contraceptive amenorrhea, galactorrhea that arose against the background of the tumor, as well as for polycystic ovaries - the result will not be long in coming. The main thing in this case is to establish precisely the causes of the pathological condition and draw up an adequate therapeutic course.
Since Klomifen is a tablet with a strong effect of exposure, their long-term use is impractical. And to prevent this, the doctor must determine the exact time to start the course. For this, for example, a woman with anovulatory infertility is offered to undergo an ovulation test (usually this is done from the twelfth to fifteenth day with a 28-day cycle or from eleventh to twentieth with an irregular one), which helps to clarify the dates of the first and last day of treatment.
How to induce ovulation using the drug "Clomiphene": instructions
Ovulation induction (stimulation of the egg maturation process with the help of special medicines) is usually indicated for patients with rare menstruation, those who are absent, and those whose cause of infertility cannot be determined. All of them are usually prescribed the most effective drug for such cases, according to experts, the drug, which is “Clomiphene”.
The feedback from practitioners confirms that it should be taken for five days at the very beginning of the cycle (standard dose is 50 mg per day at bedtime, regardless of food intake). The course of the induction process must be monitored by a specialist, checking its results using ultrasound, basal temperature measurements and determining the amount of estrogen in the blood.
As a rule, as a result of exposure to the drug, ovulation occurs 5 days after the last dose of the drug, but in some patients, it may take from 18 to 23 days. In such cases, the development of follicles is monitored by ultrasound.
By the way, taking the drug "Clomiphene" increases the likelihood of multiple pregnancy.
Side effects that prevent pregnancy when using the drug
Despite the relative safety of the described drug, the reviews of experts available on the Klomifen preparation emphasize its ability to provoke inferiority of the mucus secreted in the cervix. And this, in turn, can be a barrier to sperm, as a result of which, even with good ovulation, a woman has problems with conception. To avoid this problem, doctors recommend that patients in the first half of the cycle conduct post-coital testing after each induction of the drug “Clomiphene”.
Another negative consequence of the use of the described means is the possibility of reducing the quality of the endometrium. This is manifested in the fact that it is thinning, which makes successful implantation of a fetal egg practically impossible.
In addition to the listed side effects, some experts also note patient complaints of hot flashes, visual impairment, vaginal dryness, as well as the manifestation of ovarian hyperstimulation syndrome. Some women may also experience growth of cysts in the ovary, which is why it is considered extremely necessary to conduct an ultrasound scan before the induction course.
Contraindications
It should be noted that this drug is taken orally, while being well absorbed and metabolized by the liver. The half-life of it, as a rule, is from 5 to 7 days.
Reviews available on the drug "Clomiphene" also warn about contraindications to its use. It can not be assigned:
- pregnant
- patients with severe impaired liver or kidney function,
- with uterine bleeding of unknown etiology,
- ovarian cyst
- tendency to thrombosis,
- with tumors or pituitary pituitary,
- as well as in the presence of malignant and benign neoplasms in the genitals.
All of these diseases serve as a serious obstacle to the appointment of the named drug, so they should be reported to the attending physician in a timely manner.
The use of the drug "Clomiphene" in bodybuilding
As mentioned above, the described tool is used not only for medical purposes: both novice athletes and professionals are actively using the drug “Clomiphene”. Its use in sports is explained by excellent indicators in building muscle mass and the fact that, unlike many similar drugs, it does not reduce the concentration of natural testosterone in the blood, but, on the contrary, leads to its increased production.
In addition, experts suggest that men take the drug in case of gynecomastia, which occurs in some cases after a course of steroids (an increase in the mammary gland in men). By the way, the anti-estrogen "Clomiphene" to some extent also has anabolic properties, although not as powerful as in steroid preparations.
The drug "Klomifen": instructions for use in bodybuilding
In heavy sports and bodybuilding, the drug "Klomifen" is taken, as a rule, regardless of weight or other indicators of an athlete. Its dosage usually ranges from 50 to 150 mg per day at a time. According to experts, taking a larger amount of the drug is not advisable, because even its minimum dose (50 mg) can significantly affect the increase in testosterone levels and muscle growth.
The course of taking the described drug lasts no more than three weeks. And, as evidenced by the reviews, the named term is enough to make the effect of its application obvious.
Reviews about taking the drug "Clomiphene"
It is not difficult to find reviews about the drug Klomifen, as it is enviable among gynecologists and athletes.
True, among the many laudatory reviews there are also negative statements. But they are based, as practice proves, based on the incorrect and uncontrolled use of this drug, which, of course, entails negative consequences. They usually include nausea, vomiting, headache, discomfort and pain in the area of the mammary glands, as well as fever.
Patient complaints about mood swings and insomnia associated with taking Clomifen tablets are also frequent.
But experts once again confirm that all these phenomena in most cases are caused by improper selection of the dosage of the drug and disappear soon after its withdrawal.
A little more about Klomifen tablets
To avoid fakes of this very popular drug, it is best to purchase the drug “Clomiphene” in a pharmacy. It is available in the form of round white tablets placed in a contour package of ten pieces or in a plastic jar.
One tablet contains 0.05 g of clomiphene citrate, as well as excipients in the form of lactose, potato starch, edible gelatin, magnesium stearate and talc.
Special remarks about the drug "Clomiphene"
Judging by the reviews of experts and consumers, regardless of whether they were people taking it as a medicine or athletes who wanted to build muscle, the described drug helps to cope with problems. And therefore, despite the fact that the price for Klomifen tablets is quite high (up to 3,000 rubles), the demand for them does not decrease.
But I want to remind once again: this drug, like other medicines, in no case should you prescribe yourself and take it without consulting a specialist. You can cause irreparable harm to your health! Be careful and prudent!