For a long time, the drug "Drotaverin" is in high demand among patients. The effective work of the drug, proven in the course of multiple clinical trials, allows it to be used as a fast and readily available drug. The tool "Drotaverin" - injections or tablets - can be used both once and in the complex course of therapy for many diseases.
Creature
In 1961, the derivative Papaverine, the drug Drotaverin, was developed. In the course of clinical and pharmacological studies, the more effective work of the drug “Drotaverin” with respect to its predecessor was proved.
The drug "Drotaverin" with its main metabolites is a powerful selective inhibitor of smooth muscle tissue cells, due to this they get not only an analgesic effect, but also achieve a reduction in inflammation and edema of damaged tissues, generally receiving a positive effect on the body. Many patients wonder: “Drotaverin tablets are No-Shpa?” Yes, the No-Shpa drug is its analogue, and the Drotaverin remedy can also be replaced by many more antispasmodic medicines that are similar in composition.
Means "Drotaverin": what helps
Elimination of spasm is the main function of the drug, however, since pain is only a symptom characterized by physiological and pathological muscle contraction accompanied by certain diseases, it means that Drotaverinum is prescribed together with other medicines. The deterioration of the blood circulation of the damaged area can serve as the beginning of the pathological process.
Medical practice includes a number of cases in which the use of Drotaverin is necessary, but the main areas are:
- As a preparatory tool for patients referred to various procedures, for example, for catheterization of the ureters.
- As symptomatic therapy, in the case when pain is the main characteristic accompanying manifestation of the disease, but does not play a leading role in its pathogenesis.
How does the drug work?
The therapeutic effectiveness of Drotaverin is based on the effect on the mechanisms of muscle contraction. When the smooth muscle cells relax, the tension (tone) of the walls of the female genital organ decreases, the pain during menstruation is significantly weakened or completely eliminated. Due to the successful relief of pain, the blood supply to the walls of the organ improves.
Unlike other analgesics, Drotaverin does not erase the symptoms of the disease. The drug "Drotaverin" does not require a prescription for its purchase, it can be presented in several forms, the appointment of which should be decided by the attending physician:
- Ampoules of 2 ml contain 40 mg of the active substance Drotaverina.
- Tablets with a dosage of 40 mg of the active substance.
- Tablets "Forte" with an increased dosage of 80 mg of the substance.
Means "Drotaverin": the main directions of the drug
In case of gastrointestinal diseases, the Drotaverin drug has a rather positive effect on the body, from which smooth muscles are weakened and spasms are relieved. The tool can greatly help with the following ailments:
- Colitis.
- Pancreatitis
- Dysfunction of the sphincter of Oddi.
- Irritable bowel syndrome.
- Not ulcerative dyspepsia.
- Peptic ulcers of the stomach and duodenum.
- Papillitis
- Cholangitis.
- Pericholecystitis.
- Cholecystitis.
- Cholelithiasis.
The results of the studies showed ...
The drug "Drotaverin": what makes it so useful, and what is its advantage among other drugs? During drug testing and clinical trials aimed at studying the effect of the drug on patients diagnosed with stenosis of the sphincter of Oddi, a significant weakening of the syndrome was noted in 60% of all subjects. In this case, a more effective effect of the drug “Drotaverin” relative to other analgesics was proved.
In patients suffering from intestinal disorders, including irritable bowel syndrome, during the tests of the drug, a positive dynamics of the effect of the drug was similarly observed. The study involved 62 patients with constipation and IBS. Every day for 2 weeks, the subjects noted their complaints before the start of treatment, then for 2 months taking Drotaverin tablets 3 times a day. With active treatment, a decrease in abdominal pain was noted in 47% of patients. When taking Drotaverin, other symptoms of gastrointestinal dysfunction also decreased.
The effect of the drug "Drotaverin" on the systems and organs of the human body
As mentioned above, the Drotaverin remedy doesn’t help, it can be used for many diseases.
- It has a moderate sedative, anti-ischemic and coronary expansion effect. It has an advantageous difference from Papaverine, since the latter can reduce tone, helping to reduce blood pressure, dizziness and hyperventilation of the lungs.
- It enhances blood flow and significantly reduces the resistance of the vascular system.
- Does not affect the heart rate index, practically does not change blood pressure. Moderate hypotension can persist for half an hour after administration, no more.
- It does not affect the autonomic nervous system. Due to the direct effect of Drotaverin on smooth muscle, it can be used as an anesthetic in cases where the use of anticholinergic drugs is contraindicated - with hypertrophy or glaucoma of the prostate gland.
- After internal administration, the drug begins to act after 2-4 minutes, the maximum effect of the drug is observed after half an hour.
- Also, Drotaverinum is an active element in chronic lung diseases, hemodynamics, favorably affects the normalization of the functional state of the myocardial contractility.
- It is able to improve blood supply to tissues, as it has a vasodilating effect.
If the drug “Drotaverin” is not available in the pharmacy, its analogues can be selected as follows: “Spakovin”, “Spazoverin”, “Spazmonet Forte”, “Spazmol”, “Ple-spa”, “Nosh-bra”, “No-spa”.
Side effects of the drug
In the cardiovascular system:
- Increased heart rate.
- Feeling of heat.
- With intravenous administration, blood pressure may decrease.
- The development of the AV blockade.
- Arrhythmia.
In the respiratory system:
- With intravenous administration, depression of the respiratory center is noted.
Among others, it may be noted:
- Increased sweating.
- Dizziness.
Who should not take it
The drug "Drotaverin", from which it only does not help, but in some cases the doctor may prohibit its use. Contraindications to the use of the drug "Drotaverin" are the period of pregnancy and lactation. Also, the drug is canceled if hypersensitivity to the components of the composition is detected.
The presence of any effect of the drug on a pregnant woman has not been established. Prescribing Drotaverinum is possible only after a medical assessment of the potential risk to the fetus and a positive effect for the mother. Clinical studies in the lactation period have not been conducted, therefore, the appointment of a drug during lactation is undesirable.
Overdose
When taking the drug over the established norm, an overdose may occur, accompanied by the following symptoms:
- Heart failure.
- Paralysis of the respiratory center.
- AV blockade.
- Vascular insufficiency.
- Respiratory depression.
- Nausea.
- Vomiting
- Increased sweating.
- Pallor of the skin.
If you find these symptoms or part of them, you should immediately call a doctor.
Is it possible to assign it to children
A single dose for oral administration is 10-20 mg for children under 6 years old, 20 mg at 6-12 years, with a frequency of use of 1-2 times a day.
With increased caution, you should take the drug with arterial hypotension. During intravenous administration of the substance, the patient must certainly be in a supine position, because of the danger of collapse.
Other positive aspects of taking the drug
An advantage can be considered that when taking the medicine internally in a therapeutic dose, it in no way interferes with driving or any other potentially dangerous activity. However, after intravenous administration of the drug, it is still recommended not to drive a vehicle for some time, for approximately 1 hour.
The announced research data and doctors' own observations prove that the drug "Drotaverin" is a highly effective antispasmodic drug suitable for extensive use in various therapy. Depending on the dosage and form of release of the drug "Drotaverin", the price can range from 10 to 50 rubles.