"Tizanil" is a muscle relaxant that has a central effect. To reduce the tone of skeletal muscles, the drug Tizanil is often used, the indications for use of which allow, if necessary, to eliminate muscle cramps resulting from the development of a neurological disease, osteochondrosis, surgery or injury. In addition to the active substance tizanidine, the drug contains additional components. The auxiliary effect is due to the presence of silicon dioxide, stearic acid, microcrystalline cellulose and lactose monohydrate.
Pharmacological action "Tizanil"
Alpha2-adrenergic receptors are activated after taking the drug "Tizanil." The composition of this drug allows you to effectively deal with acute cramps and spasms in a chronic form, the origin of which is spinal or cerebral. This tool helps to reduce muscle resistance during passive movements and enhance voluntary muscle contractions.
The absorption of the drug is fast. "Tizanil" instructions for use are as a means that is absorbed almost completely, in the maximum amount found in the blood 60 minutes after entering the gastrointestinal tract.
Metabolism occurs in the liver, bioavailability corresponds to 34%, binding to blood proteins - 30%. Half-life requires an average of three hours. The drug is excreted in the form of metabolites mainly by the kidneys, its insignificant part is removed unchanged.
Indications
For the drug "Tizanil" indications for use are as follows:
- diseases of the spine with muscle cramps, which are accompanied by pain;
- painful muscle cramps after surgery;
- spasticity of the muscles of the skeleton as a result of neurological diseases.
Contraindications to taking "Tizanil"
The medicine is contraindicated in case of hypersensitivity to its components, with violations of the liver and kidneys, which are of a pronounced nature. "Tizanil" instruction does not allow use during the period of bearing a child and breastfeeding. Contraindication is the treatment with "Fluvoxamine." Age less than 18 years old also refers to contraindications.
In case of renal failure, the instruction allows the use of the drug, but with extreme caution. The same applies to the combined use of Tizanil with CYP1A2 inhibitors and treatment in old age.
The use of the drug, dosage
The medicine is taken orally. If the purpose of using the drug is to eliminate painful muscle spasms, it is recommended to use it in a dose ranging from 2 to 4 mg. The recommended dose should be taken three times a day. If the case is severe, it is allowed to add another additional dose of 2-4 mg of the drug Tizanil. Tablets instructions for use allows you to use with spasticity of the skeleton muscles in a dose of 6 mg. This is the maximum daily dose that cannot be exceeded at the initial stage of treatment. In the treatment of such conditions, three doses of the drug are carried out daily. Observing the interval of 3-7 days, the dosage can be gradually increased by an average of 3 mg.
To achieve the maximum effect, it is allowed to bring the daily dose of the drug to 24 mg. The optimal dosage is usually 12 mg or more, but cannot exceed 36 mg. At the same time, 3 or 4 doses of the Tizanil agent should be performed daily. Instructions for use contain information on the treatment of patients with renal failure. Such patients are first prescribed to take the drug for use once a day in a minimum dose, which corresponds to 2 mg. The dosage is changed gradually, taking into account the reaction of the patient. If you need to increase the dose, first increase the dosage itself, and then change the frequency of administration.
Side effects
Long-term treatment is sometimes accompanied by unwanted reactions of the body. In this case, they can develop more often and appear more pronounced. This also applies to taking large doses of the drug "Tizanil." The instructions for use report such side effects as disturbances in the digestive tract, drying out of the oral mucosa, insignificant decrease in blood pressure, fatigue, drowsiness, dizziness, and other undesirable effects.
The appearance of side effects is an occasion to consult a doctor who will either reduce the dose or cancel the drug, replacing it with another remedy. When treating with Tizanil tablets, the instructions for use must be followed so that the risk of side effects is minimized.
Drug interaction
The interaction of different medications is very important information that must be taken into account before starting treatment in order to reduce the likelihood of side effects, eliminate harm to the body and reduce the risk of treatment effectiveness.
It is known that the drug "Tizanil" combined with "Fluvoxamine" leads to a deterioration in well-being. With its simultaneous administration with antihypertensive drugs, bradycardia and arterial hypotension may develop.
If ethanol or sedatives and Tizanil tablets are used at the same time, the instruction indicates an increase in the sedative effect, which is provided by Tizanil. When combined with oral contraceptives, half clearance is possible.
Drug interactions can change the effectiveness of treatment. With the simultaneous use of several drugs, they can enhance the effect of each other or oppress. All this is fraught with the occurrence of adverse reactions, overdose, lack of the necessary result.
special instructions
Before starting treatment with the drug "Tizanil" indications for use and contraindications must be carefully studied.
Negative changes in kidney and liver function have been reported. But with therapy based on taking the drug at a dose of 12 mg or less, such cases were very rare.
It is advised to periodically take functional liver function tests. During the first four months - once a month. In situations where AST and ALT go beyond the normal range, significantly exceed them, drug withdrawal is necessary.
In some patients who take "Tizanil" (including analogues), drowsiness may appear. Being in this state, you can not engage in activities that require increased attention and quick reactions.
Due to the threat of a deterioration in the patient’s condition, the drug is not canceled abruptly;
Analogs of Tizanil
The indications prescribed in the instructions for the Tizanil agent do not always allow the use of the original due to the presence of some contraindications. The cheapest drugs include Tizanidin-Teva and Tizalud. These drugs are also muscle relaxants, are available in the form of tablets, have the same active component.
Other analogues are also made. For example, you can be treated with Midokalm, Tizanilom-Teva, Surdalud MR, Surdalud.
Reviews
Reviews about "Tizanil" are different, because the drug can affect patients in different ways. But mostly they are positive. This tool began to be produced for a long time, it has been on sale for a long time, so many people have already been able to verify its effectiveness. There are also negative reviews left due to side effects due to intolerance to the components or the use of a dose higher than that recommended for treatment with Tizanil. Positive reviews were left by people who are satisfied with the result, during the treatment they observed the dosage prescribed by the doctor, and practically did not notice any negative reactions.
Often, a medicine is used to treat osteochondrosis. Thanks to its action, the symptoms that accompany the disease disappear quickly enough. Headache and back pain pass, general health improves. Sometimes minor side effects are present, such as drowsiness, dryness of the oral mucosa, but with the right dose adjustment or drug withdrawal, they disappear. For some patients with acute osteochondrosis, which provoked radicular syndrome, it was Tizanil that returned normal mobility, while other medications did not bring the desired result.
The drug well removes high muscle tone, which was the result of a stroke. "Tizanil" is taken only as directed by the doctor if there is appropriate evidence. If treatment is required for an elderly person or a patient with a sick liver, it is better not to risk health and choose another muscle relaxant, which also copes well with the tasks.