What is a drug like clopixol? Consumer reviews and features of this medication will be considered in the materials of this article.
Forms of the drug, its composition, description, packaging
The tool in question has various forms of release. Imagine them right now.
1. “Clopixol” - tablets of pale pink, pinkish-brown and red-brown color (2 mg, 10 mg and 25 mg, respectively). They have a round and biconvex shape, as well as a film shell.
The active ingredient of this agent is zuclopentixol dihydrochloride. It also contains 85% glycerol, potato starch, copovidone, lactose monohydrate, microcrystalline cellulose, talc, magnesium stearate, hydrogenated castor oil .
The medicine in question goes on sale in plastic containers and cardboard boxes.
2. An oil solution for the intramuscular injection of “Clopixol”. Reviews claim that this product is sold in clear glass ampoules. The solution itself has a yellowish color and transparency. It is completely free of particles.
The active element of this medication is zuclopentixol decanoate. It also includes triglycerides.
Pharmacological action of clopixol
The medication in question is a derivative of thioxanthene - an antipsychotic. It has a specific inhibitory and antipsychotic effect. In addition, this remedy has a sedative effect.
A single injection of the drug contributes to the rapid weakening of all psychotic symptoms. Sedative properties of the drug appear after 2 hours, and its general effect lasts for 3 days.
Kinetic features of the drug
According to experts, it is advisable to carry out injections with this solution in periods (once every 4 weeks).
After oral administration of the drug, its peak concentration is reached after 4 hours. The bioavailability of zuclopentixol is approximately 44%.
After intramuscular administration, the main substance of this drug undergoes enzymatic cleavage. In this case, acetic acid and active zuclopentixol are formed. The last component in small quantities is excreted in breast milk and crosses the placental barrier.
When taking the medicine inside, its half-life is about 20 hours. It is excreted mainly with feces and partially with urine.
Indications for use
In what cases is the drug in question prescribed to patients? What does the instructions for use say about this? Clopixol is indicated for:
- acute and chronic schizophrenia and other psychotic disorders, including those accompanied by delusions (paranoid), hallucinations and impaired thinking;
- a state of agitation, hostility, anxiety (increased), aggressiveness;
- mental retardation, which is combined with agitation, agitation (psychomotor) and other disorders in behavior;
- manic phase of manic-depressive psychosis;
- senile dementia with disorientation, disturbances in behavior, paranoid ideas and confusion.
Drug bans
When should you not use the antipsychotic in question? What does the instructions for use say about this? Clopixol is contraindicated in:
- acute intoxication with barbiturates;
- acute alcohol intoxication;
- acute intoxication with analgesics (opioid).
It should also be noted that the mentioned antipsychotic agent is not used for coma.
Instructions for use
Clopixolum tablets are taken orally. The dosage of this drug is selected individually, depending on the condition of the patient. At the very beginning of therapy, the medication is prescribed in low doses, and then they are rapidly increased until a clinical effect is achieved.
In severe and moderate psychotic disorders, the initial dosage of Clopixol is 20 mg per day. If required, it can be increased by 20 mg.
In an acute attack of schizophrenia and other psychotic disorders of an acute nature, mania and severe agitation, the dosage of the drug is 10-50 mg per day.
With psychotic conditions of a chronic nature, as well as with schizophrenia and other psychoses, the maintenance dosage of the drug in question is 20-40 mg per day.
With agitation in people with oligophrenia, the dose of the drug is 6-20 mg per day. If necessary, it can be increased to 25-40 mg per day.
In case of senile disorders with agitation and confusion, this medication is prescribed in a dose of 2-6 mg per day. If required, then the specified amount of the drug is increased to 10-20 mg per day.
Method of applying oil solution
How should oily solution be administered? What does the instructions for use report about this? “Clopixol” is prescribed as a deep IM injection, which is carried out in the gluteal region.
The recommended volume of such an injection should be 1-3 ml. If required, then repeated injections are done at intervals of 3 days. For some patients, additional injections are prescribed after a day or two.
Undesirable consequences
What negative reactions does the drug “Clopixol” cause? This drug causes side effects very often. These include the following:
- urinary retention, violation of accommodation;
- extrapyramidal symptoms (at the initial stage of therapy), drowsiness;
- tachycardia, dizziness, orthostatic hypotension ;
- tardive dyskinesia (with prolonged treatment);
- constipation, dry mouth, transient changes in liver samples.
Overdose cases
In case of an overdose with the agent under consideration, the following symptoms are possible: coma, drowsiness, convulsions, extrapyramidal disorders, shock, arterial hypotension, hypo- or hyperthermia.
To eliminate such phenomena, the patient is washed the stomach and give sorbents. Supportive and symptomatic therapy is also performed.
Drug Interactions
The drug "Clopixolum" (10 mg) enhances the sedative effect of alcohol, barbiturates and other drugs that have a depressing effect on the central nervous system.
This medication should not be combined with guanethidine and drugs with a similar effect due to the possible blocking of their hypotensive effect.
The concomitant use of Clopixolum may decrease the effectiveness of adrenergic drugs, including Levodopa.
When combining the drug in question with "Piperazine" and "Metoclopramide", the risk of extrapyramidal signs increases.
Special recommendations
The drug "Clopixolum", the price of which is indicated below, is prescribed with caution to people with heart diseases, chronic hepatitis and convulsive syndrome.
With prolonged treatment, ongoing clinical monitoring should be carried out in order to assess the patient's condition.
When taking antipsychotics, it is possible to develop a fatal CNS. The main signs of this condition are muscle rigidity, impaired consciousness, autonomic NS dysfunction, hyperthermia.
The cost of the drug and reviews about it
The price of the medication in question depends on the form of its release. 2 mg tablets in an amount of 50 pieces cost about 250 rubles, 25 mg (100 pieces) - about 1600 rubles, and 10 mg tablets (50 pieces) - about 480 rubles.
As for the oil solution, its price reaches 2300 rubles.
Most often, consumer reviews about the drug “Clopixol” leave those patients who used this medication in the form of an injection solution. Such patients claim that the course of use of this tool is very convenient. This is due to the fact that injections should be done extremely rarely (as opposed to taking pills).
According to consumer reviews, the drug “Clopixol” is a very effective and fast-acting antipsychotic. But, unfortunately, it often causes side effects.