How to choose a suitable antifungal agent if you have thrush? Pay attention to the cream "Clotrimazole". In international medicine, it is known as Clotrimazole, a very effective antifungal agent.
"Clotrimazole cream" - instructions
Active ingredient (INN): clotrimazole
pharmachologic effect
This antifungal agent belonging to the imidazole group reduces the synthesis of ergosterol (ergosterol is the main part of the membrane of the microbial wall), which leads to a change in the properties of the cell membrane of the microbial wall and its structure. Interacting with mitochondrial and peroxidase enzymes, the active substance increases the concentration of hydrogen peroxide to a toxic level, and this accelerates the destruction of fungal cells.
Clotrimazole also inhibits peroxidase activity. This improves the accumulation of hydrogen peroxide in the fungal cell and contributes to its destruction.
Cream "Clotrimazole" also has the following effects:
- anti-amoebic;
- antitrichomonas;
- antibacterial.
Dosage form
Solution, cream and powder (for external use), also vaginal cream, ointment, vaginal tablets.
Indications
It is prescribed for skin mycoses and for urogenital candidiasis. Clotrimazole cream for thrush is especially effective for the initial signs of the disease. Unpleasant symptoms begin to disappear after the first use of the drug, but both partners must be treated to consolidate the result.
Contraindications
Cream "Clotrimazole" leads to hypersensitivity during pregnancy (I trimester) and during the menstrual period.
Side effects of clotrimazole
Burning, irritation and peeling of the skin, swelling, erythematous rashes, headache, blisters, itching of the skin.
How is clotrimazole cream used?
Application is possible in the form of a solution, in the form of an ointment (cream), spray liquid or intravaginal tablets. A thin layer of a solution or cream is applied to the affected areas 2 times a day and rubbed with smooth movements. The treatment period usually takes up to 4 weeks, and in severe cases more. To avoid the recurrence of the disease, treatment can be continued for another 3 weeks. Before lubricating the area of application, you need to thoroughly wash your hands with soap and water in warm water and dry them.
Clotrimazole is also used as a drug that treats versicolor. It is applied to areas of the skin for 10, or even more days (with an advanced illness, treatment lasts 3-4 weeks).
How does the drug interact with other drugs?
Dexamethasone inhibits the antifungal effect of clotrimazole when used in large doses.
A high concentration of propyl ether enhances the antimycotic effect of clotrimazole.
Clotrimazole can cause inhibition of the action of other antifungal agents used, and often polyene antibiotics such as natamycin and nystatin.
How and where to store?
Store in a cool and dark place.
You should know!
- You must be careful not to get into the eyes!
- After applying the cream, do not apply occlusive dressings!
- It is necessary to control the condition of the liver during treatment with the drug in patients with liver failure!
- When there is no effect for four weeks, you need to confirm the diagnosis! This can be done by passing additional tests.
- With signs of hypersensitivity or irritation, treatment should be discontinued!
What is the form of release?
- Solution - in bottles of 15 ml
- Vaginal tablets (0.1 g each) complete with an applicator - 3 pieces each.
- Cream (1%) - in tubes of 20 g.
- Vaginal cream complete with applicator - in tubes of 20g.
Sure!
Before you start to use the drug "Clotrimazole", you should definitely consult your doctor.