What is the medicine "Orthanol"? What does the medicine help from? You will find the answers to these questions below. In addition, we will present the price of the mentioned drug, its contraindications, analogues and form of release.
Drug packaging , its composition, description, form
The drug "Orthanol" is made in the form of hard capsules of size No. 1 or No. 2. This product has a white color, as well as the inscription "OME 20" or "OME 40" (depending on the dosage). The contents of the drug capsules are yellow granules.
What does Ortanol medication include? Reviews indicate that the main substance of the drug in question is omeprazole. It also has auxiliary components such as croscarmellose sodium, low-substituted hyprolose, anhydrous lactose, microcrystalline cellulose, hypromellose phthalate, povidone, polysorbate 80, talc and dibutyl sebacate.
The capsule shell contains propylene glycol, hypromellose, butanol, carrageenan, anhydrous ethanol, shellac, potassium chloride, anhydrous isopropanol, titanium dioxide, ink for lettering and water.
Ortanol (capsules) medication is available in blisters packaged in cardboard packs.
Pharmacological action
What is Orthanol (what this medicine helps, you will learn below)? According to the instructions, this drug is a proton pump inhibitor. It reduces acid production, that is, it slows down the activity of K + -H + -ATPase in the stomach, and more precisely in its parietal cells. It also blocks the last stage of the secretion of hydrochloric acid.
The drug "Orthanol", the price of which is indicated below, is a prodrug. This tool is activated in the acidic environment of the tubules (secretory) parietal cells. In addition, it reduces stimulated and basal secretion, regardless of the nature of the stimulus.
The antisecretory properties of this medication appear within the first 60 minutes (maximum after 2 hours). Inhibition of 50% of maximum secretion continues throughout the day.
A single dose of the drug provides effective and rapid inhibition of night and day gastric secretion. It reaches its maximum on the 4th day of therapy and disappears three days after the end of treatment.
Kinetic properties of a drug
After taking the drug "Orthanol" it reaches a high absorption. The peak concentration of omeprazole in the blood is observed after 0.5-3 hours. The absolute bioavailability of the drug is 30-40%, and the relationship of the drug with plasma proteins is 95%.
Omeprazole metabolism is carried out in the liver with the formation of six pharmacologically inactive derivatives.
The half-life of the drug is 0.5-1 hours. It is excreted in the form of derivatives via the kidneys (70-76%) and together with bile (18-24%).
In people with chronic liver diseases, the bioavailability of the drug increases significantly, and the half-life from plasma reaches 3 hours.
In patients with chronic kidney disease, excretion slows down. This happens in proportion to the decrease in QC.
Medication "Orthanol": what helps?
The drug in question is indicated for use in the following diseases:
- reflux esophagitis;
- gastrointestinal tract diseases of the ulcer (including for the prevention of relapse);
- hypersecretory conditions (stress ulcers of the digestive tract, Zollinger-Ellison syndrome, systemic mastocytosis, polyendocrine adenomatosis);
- Helicobacter pylori eradication in infected patients with gastric ulcer (in combination therapy);
- treatment and prevention of gastrointestinal mucosal injuries caused by NSAIDs (mucosal erosion, dyspepsia, peptic ulcer).
Drug bans
What contraindications does the Orthanol medication have (what this remedy helps, we described above)? According to the instructions, the medication in question cannot be used for:
- lactation;
- in childhood;
- hypersensitivity to drug substances.
With extreme caution, the drug in question is prescribed for renal and hepatic insufficiency.
The drug "Orthanol": instructions
This drug is prescribed only inside. It is taken immediately before meals (usually in the morning, before breakfast).
The drug capsule is swallowed in its entirety, washed down with water. In the event that the patient cannot use the medication as a whole, its contents can be dissolved in a small amount of not very acidic liquid.
The dosage of this drug depends on the indications.
With peptic ulcer of the duodenum, the drug is prescribed 20 mg once a day for two weeks. In the event that after the first course complete scarring does not occur, a repeated two-week therapy is prescribed.
For treatment-resistant peptic ulcer, this drug is recommended to be taken at a dosage of 40 mg once a day. The course of therapy with this drug can be extended up to four weeks.
Capsules "Orthanol", the indications of which were listed above, for gastric ulcer take 20 mg once a day for four weeks. If scarring does not occur after the completed course, then a four-week repeated therapy is prescribed. For gastric ulcer resistant to treatment, the drug is recommended to be taken in a dose of 40 mg once a day (course up to eight weeks).
Helicobacter pylori eradication is carried out as part of combination therapy. In this case, the medication is prescribed 20 mg twice a day before meals (for two weeks) in combination with antibacterial agents.
With reflux esophagitis, the drug is recommended to be used in an amount of 20 mg (once) for four weeks. If such a medication does not contribute to a complete cure, then the patient is prescribed a second course (four weeks). In severe reflux esophagitis, therapy with this agent is extended to eight weeks.
In hypersecretory conditions, the medication for heartburn under consideration is prescribed individually. The recommended starting dosage for adults is 60 mg (once), and the maximum is 120 mg.
When prescribing a drug over 80 mg per day, it is divided into several doses.
For injuries of the gastrointestinal tract mucosa caused by NSAIDs, as well as for the prevention of Orthanol capsules, it is recommended to use a dose of 20 mg every day, before breakfast (throughout the course of treatment of NSAIDs).
For older people and people with severe liver diseases, the highest daily dose of the drug is 20 mg.
For patients with impaired renal function, dosage adjustment is not required.
Side effects
What reactions of an undesirable nature do the Ortanol medication cause? Reviews suggest the following side effects:
- headache, visual impairment, dizziness, erythema multiforme exudative, paresthesia;
- drowsiness, nausea, taste disturbance, diarrhea, insomnia, flatulence;
- agitation, dry mouth, depression, stomatitis, reversible confusion;
- encephalopathy, gynecomastia, hepatitis, peripheral edema, vomiting, photosensitivity;
- abdominal pain, thrombocytopenia, constipation, pancytopenia, increased activity of alkaline phosphatase and liver transaminases ;
- itchy skin, impaired liver function, muscle weakness, the formation of glandular gastric cysts;
- alopecia, eosinophilia, increased sweating, bronchospasm, agranulocytosis, angioedema;
- leukopenia, myalgia, fever, arthralgia, anaphylactoid reactions, urticaria, interstitial nephritis.
Side effects that are observed with the use of the drug in question are weakly expressed and are transient.
Overdose cases
When taking a medication for heartburn, the patient may experience the following symptoms: headache, dry mouth, tachycardia, drowsiness, nausea, blurred vision, vomiting, confusion, increased sweating.
In such conditions, symptomatic therapy is performed.
Drug Interactions
With simultaneous administration with omeprazole, the elimination half-life increases and the concentration of Diazepam, Warfarin, Phenytoin, as well as other drugs that are metabolized in the liver with the participation of the CYP2C19 isoenzyme, increase.
The absorption of products whose bioavailability is determined by the acidity of the gastric juice (for example, Itraconazole, Ketoconazole, ampicillin esters, Cyanocobalamin and iron salts) may be impaired.
The bioavailability of digoxin when taken with omeprazole increases by 10%.
The drug in question enhances the inhibitory effect on the hematopoietic system of other drugs.
Clinically significant interaction of the drug with antacid medicines, caffeine, “Theophylline”, “Quinidine”, “Propranolol”, ethanol, lidocaine and “Metoprolol” has not been established.
Special recommendations
Before starting treatment with omeprazole, the presence of a malignant process should be excluded. This is due to the fact that therapy with this drug can mask the symptoms and delay the correct diagnosis.
At present, there is no data on the effect of the agent in question on a person's ability to control mechanisms and drive vehicles.
Cost and analogues
How much does an antiulcer drug like Orthanol cost? The price of this drug is approximately 100-115 rubles. For most consumers, this cost is quite acceptable.
How can I replace the drug "Orthanol"? Analogues of this drug are presented in the form of "Omez", "Loseprazole", "Gaseka", "Omelik", "Omeprazole".
Reviews
Reviews about capsules "Orthanol" to a greater extent are positive. Patients claim that this drug is an effective antiulcer drug. It quickly eliminates heartburn, as well as a feeling of heaviness and burning in the stomach.
Experts argue that the medication in question has a positive effect on the course of diseases of the digestive tract only if it has been prescribed by a gastroenterologist. Doctors report that it is forbidden to take this drug on its own, as it has a very strong effect.
Also on the positive side of this medication include its availability and cheapness.