Before disassembling the side effects of Lozap, you must understand what the drug is intended for. The medicine is hypotensive. It helps to maintain blood pressure at a safe level for the patient. Let's talk about the drug in more detail.
Structure
To identify side effects of "Lozap", you need to know what is included in the medication. The base substance is potassium losartan. As for excipients, they are also present in the composition. We are talking about magnesium stearate, povidone, dye, dimethicone, talc and others.
Any excipient that is in the composition does not have additional properties, which means that it cannot cause side effects of Lozap. In addition, these substances do not have a significant effect on the human body.
In what form is it produced?
The release form of the drug "Lozap" is the only one - biconvex tablets, which contain 12.5, 50 or 100 milligrams of losartan potassium. The medicine is sold in blisters that are in cardboard boxes. There are always ten tablets in the plate. In one box, there can be from three to nine blisters.
"Lozap Plus" contains 50 mg of losartan potassium and in addition 12.5 mg of hydrochlorothiazide.
When applied
To make everything clear, you must first analyze the indications for use, and then the side effects of Lozap.
So, patients take the drug in the following cases:
- Hypertonic disease.
- Diabetic nephropathy.
- Chronic heart failure. In this case, the medicine is part of a complex therapy.
The main reasons for the application are mentioned above, but there are also less obvious ones. These include depletion of the left ventricle. Doctors often prescribe medication for the prevention of hypertension. In this case, the side effects of Lozap fade compared with the benefits that the patient receives.
Rarely, but nevertheless, a drug is prescribed in order to reduce the risk of complications associated with the functioning of blood vessels and the heart.
Who should not be consumed?
In addition to side effects, Lozap has a number of contraindications that cannot be ignored. Among them:
- Age to eighteen.
- During pregnancy and breastfeeding.
- Hypersensitivity to one of the components that make up the drug.
- Renal stenosis
- Violations of the process of water-electrolyte metabolism.
- Liver failure.
- Lack of urine.
- Biliary obstructive diseases. This item applies only to the drug "Lozap Plus".
- Gout and hyperuremia with clinical symptoms. It's about Lozapa Plus.
- Cholestasis is also a contraindication for Lozap Plus.
As you can see, there are not so many contraindications, but nevertheless, if they exist, they cannot be ignored.
When can I use with caution?
There are conditions during which the drug is not to be used, but it is extremely careful to do this. What are we talking about? About these conditions and situations:
- Low pressure.
- Severe chronic heart failure of the fourth functional class.
- Heart failure along with severe renal failure.
- Heart failure in combination with arrhythmia.
- Ischemic heart disease.
- Cerebrovascular accident, cerebral arteriosclerosis, intracranial pressure.
- When the potassium level in the blood is higher than it should be normal.
- Patients older than seventy-five years.
- Low circulating blood volume.
- Bilateral narrowing of the renal arteries.
- Violation of the water-electrolyte balance.
- Hepatic or renal failure.
- A history of kidney transplantation.
- Mitral and aortic valve stenosis.
- Primary hyperaldosteronism.
- History of angioedema.
- Hypertrophic obstructive cardiomyopathy.
- Diabetes. The clause refers to Lozapus Plus.
- Hypochloremic alkosis. Also relevant only for Lozapa Plus.
- Hypomagnesemia - for Lozapa Plus.
- Ailments of the systemic connective tissue. A striking example is lupus erythematosus.
- A history of bronchial asthma or ongoing.
Also, do not take the drug with Ibuprofen, Nurofen or Nemisulide. In acute attacks of myopia or angle-closure glaucoma, taking the medicine is also mandatory with great care.
pharmachologic effect
Before talking about side effects with prolonged use of "Lozap", you need to understand how the drug works.
So, tablets have a complex effect. If you take the medicine constantly, then the resistance of the peripheral vessels will decrease, and because of this, blood pressure will decrease.
The medicine can reduce the load on the vessels and heart and reduce the amount of adrenaline in the blood. Doctors also warn about the diuretic effect of the drug. They also note that this is rather good, because excess fluid is removed from the tissues.
Side effects with prolonged use of "Lozap", of course, occur, but there are positive aspects. For example, patients note the body's resistance to physical activity. As a result, depletion of the heart muscle practically does not occur. It is worth noting that a similar effect is observed only in those people who suffer from heart failure.
The maximum effect of the drug is achieved six hours after administration. Over the next twenty-four hours, the drug slowly ceases to exist. With constant use, the hypotensive effect will manifest itself after 3-6 weeks.
The tablets are perfectly absorbed by the body. Substances are excreted through the kidneys and intestines.
Application features
It is foolish to judge the effectiveness of “Lozap” by side effects and reviews, because you need to look first of all at how the drug copes with problems. And for the medicine to really help, you need to know certain features of the application. What are we talking about? For example, that only the doctor can determine the dosage and frequency of admission. Nevertheless, there are general recommendations that you can keep in mind.
For patients suffering from hypertension, the drug is prescribed to drink 50 milligrams once a day. In the case when the dosage does not give the desired effect, it is allowed to increase to 100 milligrams. Before studying the reviews and side effects of “Lozap”, you must consult your doctor. He will explain that the effect occurs after constant administration for 3-6 weeks.
There are several conditions:
- With simultaneous administration with diuretics, the amount of medication cannot exceed 25 milligrams per day.
- For patients with impaired liver function, the doctor selects the dosage separately.
- In chronic heart failure, a maximum of 12.5 milligrams can be consumed per day.
- To achieve the effect, patients are prescribed 50 milligrams.
Reviews of the side effects of Lozapa Plus can be seen quite often. For this reason, many patients refuse to use the drug, but this is stupid. If you read the same reviews thoughtfully and carefully, you can see that many people did not observe the dosage or did not take the drug as described in the instructions.
To get the desired effect, it is necessary to drink the tablet without chewing it. The drug can be drunk at any convenient time, no need to guess, do it after or before meals.
Treatment begins with a minimum amount of the drug, over time it increases to the maximum maximum. This process takes 2-3 weeks.
Side effects
Now let's move on to the side effects of Lozap (we’ll study the doctors’s reviews about this medicine later). In clinical studies with losartan and hydrochlorothiazide, no adverse reactions associated with the combination of these substances were observed. From this we can conclude that the side effects of Lozapa Plus are limited to those previously observed with losartan and hydrochlorothiazide alone. Usually adverse reactions from the drug are minimized. But sometimes the patient can feel their entire spectrum.
What is attributed to the side effects of "Lozap" in honey. sources? The list is quite extensive:
- Dizziness, headache, asthenia, fatigue, insomnia. All these symptoms occur in one percent of patients and more.
- Abdominal pain and nausea are also affected by 1% of those using the medicine.
- Infections of the upper respiratory tract, nasal congestion accompany already 1% of people who take the drug.
- Pain in the chest, legs, cramps, back pain are also tormented by 1% of patients.
- Orthostatic dose-dependent hypotension, tachycardia and brachycardia, palpitations, angina pectoris, arrhythmia. If you believe the instructions and reviews of doctors about the side effects of "Lozapa Plus" and "Lozapa", this is affected by no more than 1% of people taking the medicine.
Among other side effects, anemia is observed. The same doctors say that, as a rule, the medicine does not have such pronounced side effects, but its effectiveness is proven.
In some people, prolonged use may even contribute to the development of hepatitis, but this is not a reason to refuse effective treatment.
Unfortunately, this is not the entire list of side effects. Recent studies have revealed a whole list of "gifts":
- Lowering platelet levels in the blood below normal.
- Increased eosinophil levels above normal.
- Purple Shenlin - Genoch.
- Quincke's edema.
- Skin rash.
- Vasculitis.
- Itching on the skin.
- Photosensitivity.
- Depression.
- Anxiety.
- Sleep disturbance or drowsiness.
- Numbness or goosebumps.
- Tremor.
- Impaired memory.
- Movement coordination disorder.
- Hypersensitivity to certain irritants.
- Panic attacks.
- Strange dreams.
- Confusion.
- Pain along the sciatic nerve.
- Taste disorder.
- Noise in ears.
- Decreased visual acuity or double vision.
- Vertigo.
- Conjunctivitis.
- Burning sensation in eyes.
- Blurred vision.
- Fainting.
- Cough.
- Acute cerebrovascular accident.
- Nosebleeds.
- Myocardial infarction.
- Dyspnea.
- Sinusitis.
- Rhinitis.
- Bronchitis.
- Dyspnoea.
- Bowel obstruction.
- Constipation or diarrhea.
- Vomiting or nausea.
- Gastritis.
- Pancreatitis
- Anorexia.
- Toothache.
- Dry mouth.
- Joint pain.
- Muscle pain.
- Muscle breakdown.
- Muscle spasms.
- Impotence. Perhaps this is the only side effect in men from "Lozap". All other effects are not divided into female and male.
- Decreased libido.
- Urinary tract infections.
- Frequent urination at night.
- Increased levels of potassium in the blood.
- Increased levels of urea, bilirubin, creatinine.
- Lowering blood glucose.
- Dry skin.
- Swelling.
- Increased sweating.
- Baldness.
- General malaise.
The following adverse reactions are characteristic of the Lozap Plus preparation only: agranulocytosis, leukopenia, thrombocytopenia, hyperglycemia, hypokalemia, hyponatremia, secondary acute angle-closure glaucoma and / or acute myopia, pneumonitis and non-cardiogenic pulmonary edema, jaundice, toxic epidermal necrosis.
What do doctors think about this? They advise not to use the drug uncontrollably and not to self-medicate. If any side effects are found, you should immediately visit a doctor and consult. In this case, the doctor will either lower the dose or select an analog that will not act in this way on the body.
Why can not be used during breastfeeding or pregnancy?
Above, we described the side effects of Lozap with prolonged use. But judging by the reviews, many people believe that a drug that should not be taken by pregnant women is harmful to everyone. Is it so? Now let's figure it out.
Why does the instruction not allow the use of the drug in pregnant women? This happens because there is no data on the use of the drug. Nevertheless, it is known that a medication that affects the renin-angiotensin system, during use in the second and third trimester, can cause fetal death or a developmental defect. This is due to the use of the drug during pregnancy.
If there is a need to use the drug while a woman is breast-feeding a child, then the question of which is more important is to stop treatment or stop feeding.
Overdose
We figured out the side effects of Lozap during prolonged use (reviews will be given at the end of the article), but overdose has not yet been discussed. Let's fix it.
What happens if you go too far with the dosage? According to studies, patients have a strong decrease in blood pressure, bradycardia or tachycardia.
As a treatment, forced diuresis is used, symptomatic therapy. With an overdose, hemodialysis does not give the desired effect.
Interaction with other medicines
We figured out the side effects of Lozap for joints and not only, as a result of which you realized that everything is not so scary. Now let’s talk about how Lozap behaves in combination with other medicines.
According to studies of a clinically important interaction of the drug with digoxin, hydrochlorothiazide, cimetidine, indirect anticoagulants, phenobarbital was not found.
In patients suffering from dehydration due to high doses of diuretics, blood pressure can significantly decrease with the use of the drug.
If the medication is used together with other drugs of the same property, the antihypertensive properties are enhanced.
When a patient takes Lozap and potassium-sparing diuretics, he should be prepared for the fact that the risk of developing hypoglycemia becomes higher. By the way, other preparations containing potassium also belong here.
The drug and children
We have already revealed that among the side effects of Lozap are coughing, nasal congestion and other not very pleasant bonuses. So, perhaps, for this reason, it should not be taken by children? No, the point is different. Simply, studies have not been conducted that can confirm the safety of the drug. And since there is not enough data, it is better not to risk it.
Driving
Does medicine affect car driving? In no way does the patient take medication to work with mechanisms or drive a car.
Generics
The indications and contraindications of Lozap are now clear, but what if you cannot use this medicine for some reason? Search for analogues. In the modern pharmaceutical market there are quite a lot of drugs that are similar in their actions, so there will be no problems with the choice.
So, what medicines can be called analogues?
- Blocktran.
- "Vazotens".
- "Brozaar".
- Vero-Losartan.
- "Cardomin-Sanovel".
- Zisakar.
- "Cozaar."
- Karzartan
- "Lozarel."
- "Lakea".
- "Losartan."
- "Losartan Macleods."
- "Losartan potassium."
- Losartan Richter.
- Lorista.
- "Losartan-Teva".
- "Losacon".
- "Renicard".
- "Presartan".
As you can see, if desired, you can find a drug that has the same properties, but is devoid of side effects or contraindications.
Reviews
Today we examined the instructions for the use of "Lozap" and why it is needed. It's time to go to the reviews.
Up to 90% of reviews of the drug are positive, since the drug has established itself as effective. Patients noted a significant decrease in blood pressure. Judging by the reviews, the medication helped even in cases where other drugs did not help the person.
As for negative reviews, they are extremely few. Typically, in such cases, intolerance to the drug is described by a specific person. The only thing that reviews are complaining about is the side effects of Lozapa Plus and Lozapa, because of which the drug was replaced by another with all its effectiveness.
What do doctors think
Reviews of doctors are also different. Some consider the drug effective in cases where hypertension is present in a mild form. Other doctors believe that it is pointless to use the drug in severe hypertension in combination with other heart diseases. In this case, the effectiveness of the drug is quite low. For this reason, patients are also forced to use stronger drugs.
To summarize, in general, doctors believe that the drug is good, but it should be used only at certain stages of the disease, otherwise it is pointless.
Doctors also remind that the unauthorized use of the medicine can only aggravate the course of the disease. For this reason, you should always consult your doctor.
How much is
"Lozap" costs differently, depending on the dosage. The cheapest dosage is 12.5 milligrams. A pack of 30 tablets will cost 245 rubles.
The most expensive Lozap is sold in a dosage of 100 milligrams, 90 tablets per pack. Such a package costs 810 rubles.
The price of Lozap Plus is naturally different. It is from 350 rubles.
Conclusion
Whatever option you choose: the original of the drug or its analogue, always remember that before using it is worth consulting a doctor.
Now there are a lot of skeptics who think they know better. This is actually not true. Just think, you have not studied for about ten years all the intricacies of the profession, and sometimes you can’t even imagine how complicated everything is in the human body. Nevertheless, you try to treat yourself on your own, and then go to the doctor with an advanced disease and immediately require a magic pill. What for? Isn’t it easier to come to a specialist and extinguish the disease in the bud at the slightest ailment than to try to recover from a severe form?
Even if you do not trust a specific doctor, you can go through a consultation with several specialists, and then choose the optimal treatment strategy. But no, everyone considers themselves the smartest and makes themselves worse in the first place.
Of course, in our country, unfortunately, there are a lot of frankly bad specialists, but this is not a reason not to take care of our health. Even a poor specialist will help with a mild form of the disease, but at an advanced stage, you will already have to look for a competent doctor. Remember that you can’t buy health for any money, even if they are, so it’s better to think about it in advance.
As for medicines, always read the instructions for use and do not self-medicate. Whatever neighbor advises you, always consult a doctor. One drug is suitable for one person, and another patient will die of it. Maybe too rude, but the way it is. Have you seen the list of contraindications and side effects to Lozap? And probably, they concluded that it should not be used? But such a conclusion is fundamentally wrong, because only a doctor can correctly select the dosage and frequency of use or find a suitable analogue. Be healthy!