How much does it cost and in what dosage can Pangrol be prescribed? Instructions for use, the price of this medicine will be presented a little further. You will also learn about the form in which the mentioned drug goes on sale, whether it can be given to children, whether it has side effects and contraindications.
Description, composition, shape and packaging
In what packaging does the Pangrol drug go on sale? The instruction is enclosed in a cardboard box, where the drug itself is contained (in blisters or a plastic jar).
The preparation in question is made in the form of gelatinous, hard and opaque cylindrical capsules. They contain small tablets that have an enteric coating and a light beige color.
Also, this medication can be purchased in the form of biconvex tablets.
What substances are contained in Pangrol 20000? The instruction reports that the active component of the tablets is pancreatin. They also include crospovidone, lactulose monohydrate, talc, microcrystalline cellulose, polysorbate 80, silicon dioxide, emulsion simethicone, magnesium stearate, macrogol 6000, a copolymer of ethyl acrylate and methacrylic acid, sodium carboxymethyl cellulose and methylhydroxypropyl cellulose.
As for the capsules "Pangrol 25000" (method of application and dose will be presented below), pancreatin also acts as their active substance. In addition, the mini-tablets contain additional ingredients in the form of microcellulose, silicon dioxide, croscarmellose sodium, castor hydrogenated oil and magnesium stearate.
Also in the pharmacy you can buy enteric-soluble capsules "Pangrol 10000".
Pharmacology
What is the medicine "Pangrol"? The instruction reports that this drug is a digestive-enzymatic agent. It helps make up for the lack of substances that are necessary for the stable functioning of the pancreas. In addition, the medication in question is capable of exerting amylolytic, lipolytic and proteolytic effects.
Operating principle
What is the mechanism of action of the drug "Pangrol"? Instructions for use (the price of this medicine is quite high) reports that the powder from which the medicine is made is obtained during the processing of the pancreas of animals (in particular pigs).
The enzymes contained in this medicine have a beneficial effect on the digestive system. They improve the digestion process, normalizing the pancreas.
Due to this effect, the drug in question is able to eliminate such unpleasant symptoms as abdominal pain, shortness of breath, a feeling of fullness of the stomach, gas, a feeling of heaviness in the stomach.
Taking capsules or tablets stimulates the stomach and intestines, as well as the pancreas, to produce enzymes that are directly related to the digestive process.
Bile extract, which is part of the medication, is able to enhance the emulsification of fats and exert a choleretic effect, improving the absorption and digestion of fats, as well as fat-soluble vitamins such as A, E and K.
Pharmacokinetic features
Is the Pangrol drug absorbed? The instruction reports that this drug is not absorbed by the digestive tract.
Tablets and capsules are coated with an acid-resistant coating that helps protect the drug from the effects of gastric juice. After the drug enters the intestine, its capsule dissolves and releases the drug substance, which, when mixed with the contents, provides the required level of enzymes and their uniform distribution.
To achieve the maximum therapeutic result, experts recommend maintaining a slightly alkaline pH in the intestine.
The medication in question is excreted with feces.
Indications
For what purpose can the Pangrol medication be prescribed? The instruction reports that it is actively used for replacement treatment of impaired pancreas. In addition, the drug in question is used for enzyme deficiency, which was caused by the following diseases:
- intestinal infections;
- narrowing of the duct of the pancreas;
- Schwachman-Diamond syndrome;
- pancreatitis
- IBS;
- pancreas cancer;
- cystic fibrosis;
- digestive tract disorders.
It should be noted that this medication can be prescribed to the patient before an x-ray or ultrasound of the abdominal cavity. It is also used to normalize the functioning of the stomach and pancreas after surgery.
Contraindications
Can Pangrol be prescribed for children? The instruction reports that this drug can be used in the treatment of small patients.
The following conditions are contraindications to taking the medication in question:
- exacerbation of pancreatitis;
- acute pancreatitis;
- hypersensitivity to the ingredients of the drug.
"Pangrol": instructions for use
The description of this medication was presented above. Use it only if indicated.
The drug is taken in the process of eating food without chewing and drinking with liquid. Its dosage should be determined by a gastroenterologist (depending on the condition of the person, the form and severity of the disease).
According to the instructions, the average therapeutic doses of this agent are:
- for adult patients - 1-2 capsules of "Pangrol 25000" or 2-4 capsules of "Pangrol 10000";
- dosage for children is calculated according to this scheme: 500-1000 units of lipase per kg of weight.
As for the "Pangrol 20000", then such tablets are usually taken in 1-2 pieces. If necessary, a gastroenterologist can increase the dose (but not more than 15,000-20000 units of lipase per kilogram of weight).
The duration of therapy also depends on the patient's condition. If a person cannot take the capsule as a whole, then its contents are allowed to be poured into a liquid or food, which should not be chewed. The resulting mixture must be consumed immediately.
Side effects
During the administration of the medication in question, the patient may experience adverse reactions such as vomiting, bloating, diarrhea, abdominal pain, nausea, and other symptoms of an indigestion.
Very rarely, patients are allergic to Pangrol (itching, hives, or a rash on the skin). Such conditions require urgent withdrawal of the drug.
Special recommendations
The drug in question does not affect the patient's ability to drive vehicles and work with complex mechanisms.
In the treatment of a disease such as cystic fibrosis, people who have received large doses of the drug may develop fibrosing colonopathy. To avoid such changes, before taking the drug, you must undergo a medical examination to exclude colon lesions.
Lactation and the period of pregnancy
There are no reliable results of clinical trials that were aimed at identifying the consequences of the influence of "Pangrol" on the fetus. However, experts say that pancreatin does not have a toxic effect on the development of the baby. Therefore, the drug in question can be used during pregnancy and lactation, but only if absolutely necessary and as directed by a doctor.
Analogs and price
To date, a huge number of drugs are produced that contribute to normal digestion. The main analogues of the drug "Pangrol" can be considered such medicines:
- Panzinorm.
- Pancreatin.
- Mezim.
- Panzinorm Forte.
- "Festal".
- Pancreatin Forte.
- "Gastenorm Forte."
- Penzital.
- "Creon."
- "Pansitrat."
- Mikrazim.
- Enzistal-P.
- Mezim Forte.
- "Pankrelipaza."
- "PanziKam".
- Pancreatin-LekT.
- The Hermitage.
- Panzim Forte.
The price of the medication in question depends on the form of its release. A package of “Pangrol 20000” with 50 tablets can be purchased for 1000 rubles. The cost of "Pangrol 10000" with 20 capsules is 250 rubles. And the average price of Pangrol 25000 (20 capsules) does not exceed 1100 rubles.
Reviews
Now you know what Pangrol 20000 is. The instructions, price and indications for the use of this medication have been described above.
The vast majority of patients who took this medication leave positive reviews about it. "Pangrol" quickly and fairly effectively eliminates all the symptoms of indigestion.
As for negative responses, in them patients report that the dosage of this agent should be calculated very carefully.