Angina pectoris, coronary heart disease and arterial hypertension are those diseases that nowadays increasingly affect people. The reason for this is the rapid pace of life, constant stress and many other factors. In order to stabilize the functioning of the heart muscle, doctors often prescribe the medicine "Prestance" and its analogues to patients. But before moving on to consider the substitutes for this drug, you need to familiarize yourself with its characteristics and properties.
Pharmacological characteristics of the drug
This combined medication belongs to the group of calcium channel blockers and ACE inhibitors. Its complex effect is due to the presence of two main active components. The first, perindopril, is responsible for the inactivation of bradykinin. The consequence of this effect is the inhibition of ACE. Moreover, in patients there is a decrease in both systolic and diastolic pressure, as well as an improvement in peripheral blood flow, vasodilation, restoration of elasticity and structure of arteries.
As for the second active component of the drug, then it is amlodipine. This substance belongs to the dihydropyridine group. It blocks slow calcium channels due to the fact that it activates the process of inhibiting the transmembrane transition of calcium ions into smooth muscle cells and cardiomyocytes of the vascular wall. Any analogue of Prestanza, which includes amlodipine, causes the expansion of peripheral arterioles, and also reduces the need for myocardial oxygen.
Form of drug release and contraindications
It is worth recalling that this medication is prescribed for coronary heart disease and arterial hypertension. However, there are a number of ailments in which the medicine is strictly contraindicated. So, do not prescribe the drug for cardiogenic shock, unstable angina, renal failure, aortic stenosis and others. It is also worth noting that any analogue of Prestanza, which contains amlodipine and perindopril, is forbidden to use for idiopathic and hereditary angioedema, during pregnancy and lactation, as well as for lactase deficiency, hereditary lactose intolerance and patients under 18 years of age.
As for the form of release of the drug, then it is only one - tablets. However, we should not forget that the medication consists of two main components. This fact was taken into account by the manufacturer and reflected the ratio of the content of active substances using the form of tablets. In oblong - 5 mg of each substance, in square (5/10) - 5 mg of perindopril and 10 mg of amlodipine, in triangular (10/5) - vice versa. But the round ones contain 10 mg of each active substance.
Analogs of means
Of course, those people who suffer from chronic coronary heart disease or arterial hypertension know what the analogues of Prestance tablets are. For those who first encountered the ailments mentioned above, a little understanding of this issue should be made. But first it is worth noting that this information does not need to be taken as a guide to action and independently replace the drug prescribed by the attending physician.
To date, the only structural analogue of Prestanza is Dalnev tablets. However, drugs such as Amlodipine and Perindopril can also be attributed to the same group. As for drugs that are similar to the drug "Prestance" in pharmacological action, their list is much larger. And the leading positions in this list are occupied by such drugs as Equator, Enanorm, Triapin, Coripren, Equacard, etc.
We will familiarize ourselves with each of the above medicines in more detail. But first, it is worth saying that, like Prestans, analogues, generics, are dispensed from pharmacies only by prescription.
Pills "Danev"
The main active components of this medication are perindopril and amlodipine, as in the Prestans remedy. The only distinguishing feature of these two medicines is the ratio of the main active ingredients. So, the "Dalnev" tablets are available with a dosage of 5: 4, 10: 4, 5: 8 and 10: 8. In this case, the first digit corresponds to the amount of amlodipine, the second, respectively, indicates how many mg of perindopril is contained in 1 tablet. If we draw an analogy, we can say that Dalnev tablets with a dosage of 5/4 are almost identical to Prestance 5/5. However, what kind of ratio of the main active ingredients for the patient will be the most effective and safe, should be determined only by the doctor.
Reviews about the drug
Most people who took this medication are very happy with the result of the treatment. Due to the mild action of the drug, a gradual decrease in pressure is observed in patients. Also, the benefits of the drug include the absence of withdrawal syndrome and the duration of the action. Based on the foregoing, we can conclude that Dalnev tablets are a cheap analogue of Prestanza, which is not inferior in pharmacological action.
Despite a decent list of benefits, there are those patients who very categorically negatively respond to the drug. And most of these people felt the side effects of the medicine.
Amlodipine and Perindopril
Despite the fact that the Prestans preparation contains instructions for use, analogues such as Amlodipine and Perindopril are not mentioned, they deserve attention.
It probably makes no sense to talk about the pharmacological action of each of these drugs. Suffice it to recall that they are both part of the Prestans facility. since each medication is issued separately, the doctor can in each case select an individual ratio of the components necessary for the treatment of the patient. In addition, if one of the medicines is contraindicated for the patient, then he can limit himself to taking the second one without harm to health. Therefore, considering the drug "Prestance", analogues, such as the drug "Perindopril" and "Amlodipine", must be studied.
Means "Equator"
This antihypertensive medication also consists of two active components. The first, as in the Prestance medicine, is amlodipine, the second is lisinopril. And if we have already familiarized ourselves with the pharmacological characteristics of one component earlier, then a few words should be said about the second. Firstly, this substance contributes to a decrease in OPSS, a decrease in blood pressure and pressure in the pulmonary capillaries. Secondly, lisinopril increases myocardial tolerance to increased loads in people suffering from heart failure. And, thirdly, this component of the drug helps to expand the arteries rather than the veins. Due to such a complex effect on the body, this Prestance analogue is effective in essential arterial hypertension.
The medicine is only available in tablet form with a dosage of 5/10 mg and 10/20 mg (lisinopril / amlodipine).
Reviews about the drug
Most of the positive reviews of patients are caused not only by the effectiveness of the drug, but also by its other positive characteristics. So many people say that the drug very gently stabilizes blood pressure and maintains normal conditions for a long time. And even despite the fact that the medication has a large list of side effects, they occur very rarely.
Only those patients whose body reacted negatively to taking the medicine respond negatively. In addition, like the Prestance medication, the instructions for use recommends that the analogues be taken in accordance with a clear dosing system. Spontaneous increase or decrease in the dose of the drug can cause the patient to worsen and lead to many negative consequences.
Means "Enanorm"
This is a combined antihypertensive drug, consisting of two antihypertensive drugs with a complementing mechanism for lowering blood pressure: enalapril - an ACE inhibitor and nitrendipine - a slow calcium channel blocker. Indications for its use are essential hypertension (that is, the drug is prescribed for patients who require combination therapy).
Like the drug Prestance, Russian and foreign analogues have a fairly impressive list of side effects. And most often it is with this fact that negative reviews of people who use antihypertensive drugs are associated. And the medicine "Enanorm", unfortunately, is not an exception.
In most cases, patients respond positively to the drug and are satisfied with the treatment results.
Means "Triapin"
With moderate arterial hypertension, the doctor may prescribe not only the Prestance 5/5 analogue. And most often in such situations, the specialist recommends the patient a means of "Triapin", the main active components of which are ramipril and felodipine. This medicine effectively lowers blood pressure and lasts 24 hours. The therapeutic effect is observed after 60-90 minutes after the application of a single dose. The duration of treatment is 21-28 days, after which blood pressure stabilizes over a long period of time. About the need for a second course of treatment of this drug can only be judged by the attending physician in each case.
Drug Reviews
The advantages of the remedy noted by patients include the rapid hypotensive effect and duration of the medication, which allows you to take pills only 1 time per day. In addition, many patients note that this Prestance 10/5 analogue, when following the dosing system, very rarely causes adverse reactions and is well tolerated.
But those who are not very flattering about the tool, justify their opinion precisely by the presence of many side effects, some of which they experienced.
The drug "Coriprene"
With essential hypertension, doctors recommend that patients take Prestance 10/10. Analogs in such situations can also be effective, and one of them is the medicine “Koripren”. The composition of this tool includes two active substances. The first, an ACE inhibitor, is enalapril, the second is lercanidipine, which belongs to the group of slow calcium channel blockers. Due to this complex composition, the drug lowers blood pressure.
The product is released exclusively in tablet form. But the dosage is calculated only by the doctor, taking into account the nature and severity of the disease, as well as the individual characteristics of the patient.
Drug Reviews
The negative attitude of patients to the medicine is explained by the presence of a large number of contraindications and side effects, as with the Prestance remedy. Instructions for use, reviews, analogues are recommended to be used only as directed by the attending physician, who will select the safest and most effective dosing system. This is the only way to avoid the negative effect of the drug on the body and normalize the state of health. And almost everyone who listened to these recommendations is very pleased with the result of the treatment and responds positively to the “Coripren” medicine.