A complex drug with analgesic, antipyretic and anti-inflammatory effect. What is the composition and recipe in Latin "Pentalgin-N" has?
The drug is produced in tablet form. The tablets have a flat-cylindrical shape, color from milky to yellowish. Tablets are packaged in contour cells of ten pieces, in total one or two blisters are packaged.
The composition of the drug contains the following active substances:
- analgin - three hundred milligrams;
- naproxen - one hundred milligrams;
- caffeine - fifty milligrams;
- phenobarbital - ten milligrams;
- codeine - eight milligrams.
In addition to active substances, the following components are included in the structure of a medicinal product:
- starch;
- povidone;
- sodium citric acid;
- magnesium stearate.
What properties does Pentalgin-N have?
The composition of the drug includes the main substances that have analgesic, antipyretic, anti-inflammatory and soothing effects.
Metamizole sodium is considered a pyrazolone derivative. The substance has an analgesic and antispasmodic effect. Naproxen has an antiperitic, analgesic and antipyretic effect, which are caused by a non-selective slowdown of cyclooxygenase activity, which is responsible for the production of prostaglandins from omega-6, an unsaturated fatty acid.
Caffeine helps expand the blood vessels of skeletal muscle tissue, heart, increase physical and mental performance, reduce fatigue and drowsiness. By increasing the permeability of histohematological barriers and increasing the bioavailability of non-narcotic painkillers, caffeine leads to an increase in their pharmacological effect.
Codeine has the ability to activate opioid nerve endings in various parts of the nervous system, which leads to the active functioning of the antinociceptive system and improve the perception of pain at an emotional level.
Phenobarbital and codeine have an enhanced analgesic effect. Metamizole sodium and naproxen are remarkably absorbed in the stomach and intestines. About fifty to sixty percent of active metabolic products bind to plasma proteins. The components of the drug may pass into breast milk. Metabolites with urine are excreted.
The bioavailability of naproxen is ninety-five percent; it binds to plasma proteins. The elimination half-life is from twelve to fifteen hours. It is excreted mainly by the kidneys, with bile - in small quantities.
Caffeine in the intestines is well absorbed. It is excreted mainly with urine in the form of metabolic products, in unchanged form - about ten percent.
The bioavailability of phenobarbital is about eighty percent, and about fifty percent binds to plasma proteins. It has the property of easily penetrating the placenta. The exchange process is carried out in the liver with the advent of metabolites. It is removed from the body with urine, including unchanged, by twenty or twenty-five percent.
Codeine binds to blood proteins in small quantities. It is exchanged in the liver. Urine is excreted unchanged - only fifteen percent.
"Pentalgin-N" is not available from pharmacies without a prescription.
Indications
"Pentalgin-N" is prescribed in the presence of the following diseases and ailments:
- Pain of various origins of mild to moderate strength.
- Headache.
- Neuralgia is a disease that is characterized by pain in the zone of greatest sensitivity of a nerve.
- Migraine is a disease, the most common signs of which are episodic or regular excruciating headache attacks.
- Myalgia is a pain in the muscles.
- Radiculitis - lesions of the roots of the spinal cord, causing motor, autonomic and pain disorders.
- Toothache.
- Algodismenorea - painful menstruation, accompanied by a violation of the general condition.
- Colds.
Contraindications
Like any other drug, Pentalgin-N has a number of contraindications for use, for example:
- Impaired functioning of the kidneys.
- Clinical syndrome, which is characterized by a decrease in hemoglobin in plasma.
- Bronchial asthma is a chronic inflammation of the respiratory system.
- Bronchospasm is a pathology that occurs when muscles of the bronchi are contracted.
- Respiratory depression.
- Gastric ulcer - a chronic polyetiological pathology that occurs with the formation of ulcerative lesions in the stomach, a tendency to progression and the formation of complications.
- Arterial hypertension is an increase in blood pressure.
- Acute myocardial infarction is an ischemic disease of the cardiovascular system, which occurs with the onset of ischemic necrosis of the myocardial site.
- Arrhythmia.
- Children's age up to twelve years.
- Pregnancy.
- Breast-feeding.
- Increased individual sensitivity to any component.
- Elderly age.
How to take the drug?
Pentalgin-N is taken orally. It is recommended to take one capsule up to three times a day. The maximum daily dose of the drug is four tablets. Without the appointment of a medical specialist, you can not take the medication for more than five days as an anesthetic and more than three days as an antipyretic drug. When prescribing Pentalgin-N, the doctor should prescribe the prescription.
Adverse reactions
Pentalgin-N tablets, if used improperly, can cause unwanted effects in the human body, for example:
- Dizziness.
- Drowsiness.
- Nausea.
- Vomiting
- Constipation - delayed, obstructed, or systematically insufficient bowel movements.
- Granulocytopenia - a decrease, below the accepted norm, of the number of granulocytes with a general decrease in leukocytes in plasma.
- Leukopenia - a decrease in the concentration of white blood cells in the blood.
- Agranulocytosis is a pathology in which there is a decrease in the number of leukocytes due to granulocytes.
- Disorders of the kidneys.
- Urticaria is a skin disease that is characterized by the rapid onset of itchy blisters.
Overdose
In case of drug poisoning, the following symptoms may occur:
- Nausea.
- Gastralgia is an unpleasant feeling associated with actual or possible tissue damage.
- Heart rhythm disturbances.
- An increase in heart rate from ninety beats per minute.
- Delirium is a disorder of thinking, which is characterized by the appearance of not corresponding to reality and not amenable to correction.
- Respiratory depression.
Therapy in case of an overdose consists in inducing vomiting, as well as washing the stomach and taking adsorbents. In this case, it is possible to carry out complex treatment, which is aimed at maintaining the work of vital organs.
Features
During the use of "Pentalgin-N", it may be difficult to diagnose acute abdominal pain. In patients with seasonal allergic rhinoconjunctivitis and atopic bronchial asthma when using the drug, the risk of developing hypersensitivity reactions increases.
Poi long (more than five days) the use of the drug should monitor the liver and peripheral blood picture. During the use of the medication, the results of doping control in athletes may vary.
Since Pentalgin-N can provoke such negative reactions as dizziness and drowsiness, when using capsules, you must refrain from driving a car and performing activities that require increased attention and a quick reaction. Pentalgin-N is released according to a prescription in Latin from a medical specialist.
Can I use the drug during pregnancy?
According to the instructions for use, Pentalgin-N is forbidden to use during an "interesting position" and breastfeeding. If it is necessary to take the drug during lactation, feeding must be stopped and the child transferred to infant formula.
For children under twelve, Pentalgin-N is contraindicated. In addition, it is not recommended to use the drug for people suffering from severe renal failure and liver. Patients of retirement age must be especially careful when taking the medicine. The drug "Pentalgin-N" is released by prescription in Latin.
Interaction
Taking "Pentalgin-N" together with certain medications can lead to the following reactions:
- With non-opioid painkillers , increased intoxication occurs. Simultaneous use with allopurinol, tricyclic drugs, oral contraceptive pills provokes an increase in the toxicity of metamizole sodium.
- Phenylbutazone and barbiturates together with "Pentalgin-N" cause a weakening of the effects of metamizole sodium. The use of the drug with cyclosporins lowers the level of the second substance in the blood.
- The concomitant use with tranquilizers and sedative drugs helps to enhance the analgesic effect of Pentangin-N.
Analogs
The following medicines are considered substitute drugs:
- "Piralgin".
- Efferalgan.
- "Baralgin M".
- Maxigan
- Spazgan
- "Spazmalin."
- Sedalgin Plus.
- Ibuprofen
- Tetralgin.
- "Banalgin."
Storage conditions
Keep "Pentalgin-N" is necessary in a dark place at a temperature of no more than twenty-five degrees. Keep away from children. Shelf life is thirty-six months. Sample recipe for Pentalgin-N:
Rp .: Codeini 0.008
Coffeini 0.05
Naproxeni 0.1
Metamizoli Natrii 0.3
Phenobarbitali 0.01
Dtd No. 10
S: 1 tablet for pain.
Opinions
There are a lot of reviews about Pentalgin-N, and in most cases they are positive. Absolutely all patients who wrote responses, the medication helped to eliminate the pain of various etiologies.
Capsules have also proven themselves well as an antipyretic drug for colds. People note that the medication acts instantly, the analgesic effect lasts quite a long time. Many users prefer to keep this medicine in their home medicine cabinet. The price of Pentalgin-N varies from 200 to 300 rubles.