In the article, we will consider the description of "Espa-Lipona" and its analogues.
It is a hepatoprotective drug that can increase the resistance of the liver to the influence of adverse factors. In addition, the effect of Espa-Lipon extends to the regulation of carbohydrate and lipid metabolism in the body.
The manufacturer comes in tablet form. The tablets of the drug have a round, convex shape on both sides, have a yellow color, are coated on top. There is also an injectable form of the drug. The solution is transparent, has a greenish-yellow hue.
What is the composition of Espa Lipon? Analogs will be considered below.
The main active substance in the composition of the drug is thioctic acid. As auxiliary substances are used: magnesium stearate, silicon dioxide, sodium carboxymethyl starch, colloidal silicon dioxide, microcrystalline cellulose, lactose monohydrate, povidone.
Analogs and reviews about the drug "Espa-Lipon" are presented at the end of the article.
Pharmacological effects
According to the manufacturer’s annotation, “Espa-Lipon” is characterized by hepatoprotective, hypocholesterolemic, hypoglycemic, detoxification activity, is able to regulate metabolic processes. Thioctic acid, which is part of the medication, takes part in the oxidation of pyruvic acid and alpha-keto acids, helps to improve the functional state of the liver, and stimulates cholesterol metabolism.
By the nature of its effect, thioctic acid resembles B vitamins. Against the background of the use of Espa-Lipon, the amount of glycogen in the liver cells increases, the concentration of glucose in the blood plasma decreases, and violations of the sensitivity of cells to the effects of insulin are eliminated. The medication allows you to remove toxins from the body, protect the cellular structures of the liver from the effects of toxins, protect the body if intoxication occurs with salts of heavy metals.
“Espa-Lipon” has a neuroprotective effect, which consists in inhibiting peroxidation of fats in nerve tissues, facilitating the processes of neuromuscular conduction through cells, and activating endoneural circulation.
According to reviews, the use of the drug in patients with motor neuropathy leads to the appearance of large amounts of macroergic compounds in the muscles.
Espa-Lipon, when administered orally, is rapidly and well absorbed in the digestive organs. It should be noted that while taking with food, the quality and speed of absorption are significantly reduced.
The active substance of the drug is metabolized by conjugation, as well as oxidation of the side chains. The elimination of the active component is carried out in the form of metabolites together with urine. The half-elimination period of the drug reaches 20 minutes.
Espa Lipon is characterized by a “first pass” through the liver tissue. This means that the active properties of the drug are somewhat reduced, since they are affected by the body's natural defenses.
Photos of Espa Lipon and peers are also presented.
Indications for use
In accordance with the manufacturer's annotation, "Espa-Lipon" is indicated for use if the patient has the following deviations.
- Chronic, acute intoxications provoked by fungi, salts of heavy metals, other toxic substances.
- Hepatic pathologies, including chronic hepatitis, cirrhosis.
- Polyneuropathy having an alcoholic, diabetic or other etiology.
In addition, the use of the drug is recommended for atherosclerosis as a prophylactic for arterial pathologies.
Analogs of "Espa-Lipona" in pharmacies of any city can be purchased.
Contraindications
Espa-Lipon should not be prescribed to patients who suffer from a chronic form of alcohol dependence, glucose-galactose malabsorption syndrome, and lactase deficiency.
Caution must be exercised when using Espa-Lipon in patients with diabetes. In addition, in this case, dosage adjustment of hypoglycemic drugs is necessary. It is unacceptable to use the drug under the age of 18 years, since clinical practice does not have enough data confirming the safety of the drug in relation to patients of this age group. If there are important indications, then the use of the drug in such patients is allowed, however, it is necessary to adjust the dosage individually and constant monitoring by a specialist.
Also, the safety of the medicine for the fetus is not proven if the drug is used during pregnancy. If the use of Espa-Lipon is required in the lactation period, the woman is recommended to temporarily abandon natural feeding.
Negative impact
In accordance with the reviews, “Espa-Lipon” is well tolerated, only in exceptional cases, against the background of its use, the following negative symptoms may develop.
- Allergic manifestations: anaphylactic shock, hemorrhagic rash, urticaria, eczema.
- Cramps, increased sweat.
- Shortness of breath, headache, vomiting, nausea.
In patients with peripheral type polyneuropathy, goose bumps may appear in the initial stages of therapy. A quick injection of an intravenous solution can provoke increased intracranial pressure, visual impairment, and the appearance of pinpoint hemorrhages in the mucous membranes and skin.
Use of medication
The tablets of the drug must be taken orally, not allowing them to be chewed. An injection solution for intravenous administration is prepared from a concentrated substance using an isotonic sodium chloride solution for dilution.
For the treatment of diabetic polyneuropathy, it is indicated to take 600 mg once a day, either twice or three times a day, 200 mg each.
For the treatment of severe diabetic polyneuropathy, it is shown to take 600 three times a day.
Analogs of Espa-Lipona
In pharmacy chains, you can buy such analogues as: “Thioctacid”, “Thiogamma”, “Lipamide”, “Oktolipen”, “Berlition”, “Phosphogliv Forte”, “Phosphogliv”, “Hepatomax”, “Sirepar”, “Hepatosan” ”,“ Essentiale ”,“ Darsil ”,“ Galstena ”,“ Karsil Forte ”,“ Karsil ”,“ Silibor ”,“ Livolin Forte ”.
It is important to remember that all these drugs have specific contraindications and are able to provoke various negative symptoms, and therefore, the use of analogues should be agreed with a specialist.
Thioctacid
According to its pharmacological effect, the Espa-Lipon analog is a metabolic agent. The main active substance in Thioctacid is thioctic acid. The medicine is available in tablet and injection form.
The main indications for use are as follows.
- Alcohol-induced polyneuropathy.
- Diabetic polyneuropathy of the sensory-motor type.
The main contraindication to use is the presence of individual sensitivity to substances in the composition of the drug. Due to the fact that there is no clinical data on the safety of the drug during pregnancy and in the lactation period, experts recommend that it be abandoned in such cases.
Taking the Espa-Lipon analogue can trigger the development of the following negative symptoms.
- Negative effects of the digestive tract (vomiting, diarrhea, nausea, pain).
- Manifestations of an allergic nature - urticaria, skin itching, rashes.
When using the medication intravenously:
- Visual disturbances, minor hemorrhages, bleeding, convulsions.
- Shortness of breath, sudden jumps in intracranial pressure.
- Anaphylactic shock, itching, skin rash.
Thioctacid should be taken orally on an empty stomach, at least half an hour before a meal, once a day, 600 mg each. The use of an injection form involves the introduction of 600 mg of the drug per day, after a month the dosage can be reduced by half.
What other analogues of Espa-Lipon 600 mg can be found on sale?
Tiogamma
Produced by the manufacturer in the following forms.
- The concentrate used to make the injection solution. The main active substance in its composition is meglumine thioctate.
- An infusion solution, the main active ingredient of which is thioctic acid, meglumine salt.
- Tablets in which the active ingredient is thioctic acid.
The main indications for the use of Tiogamma are as follows.
- Intoxications, accompanied by severe clinical symptoms.
- Polyneuropathy of the peripheral, sensory-motor type.
- Hepatic pathologies - fatty degeneration of hepatocytes, a diverse etiology of cirrhosis and hepatitis.
- Alcoholic damage to the nerve trunks.
- Diabetic type neuropathy.
The use of the Espa-Lipon analog is contraindicated if the patient has the following physiological or pathological conditions:
- Galactose-glucose malabsorption (for tableted "Thiogamma").
- Predisposition to the occurrence of lactic acidosis.
- Acute forms of circulatory disorders in the brain.
- Diabetes mellitus in decompensated form.
- Alcoholism in a chronic form.
- Exicosis, dehydration.
- Hyperacid gastritis, gastric ulcer.
- Respiratory, cardiovascular failure in decompensated stages.
- Myocardial infarction in the acute period.
- Lactation period, pregnancy.
- Childhood.
- Intolerance to the components.
The following negative symptoms may develop during the use of Thiogamma: allergic responses, dyspnea, jumps in intracranial pressure, urticaria, eczema, local redness, taste disorder, dyspepsia, diplopia, cramps, headache, dizziness, thrombocytopenia, thrombophlebitis, purpura.
Thiogamma tablets should be taken once a day, 600 mg each. When using intravenous infusion, 600 mg of the drug should also be administered.
Berlition
It is another analogue of Espa-Lipon. The manufacturer produces in tablet and capsule forms, there is also a concentrate intended for the manufacture of an injection solution. The main active ingredient is thioctic acid.
According to its pharmacological effect, Berlition is a hypoglycemic, lipid-lowering, hepatoprotective, hypocholesterolemic drug.
The main indications for the use of Berlition (an analogue and substitute for Espa-Lipon) are polyneuropathy of the diabetic and alcoholic types.
The use of the drug is contraindicated in childhood, in the presence of hypersensitivity to the components of the drug, during pregnancy, in the lactation period. Tableted Berlition should not be used for hereditary sugar intolerance. A similar ban is due to the presence of lactose in the preparation.
With the use of Berlition in any pharmacological form, the following negative symptoms may develop.
- Anaphylactic shock (rare).
- Allergic manifestations (urticaria rash, itching, other reactions).
- Headaches, hyperhidrosis, dizziness, blurred vision, hypoglycemia.
- Decreased blood glucose levels.
- Taste disorder.
As indicated by the instructions for use with the Espa-Lipon analogue, the use of parenteral forms can cause:
- Jump in intracranial pressure, shortness of breath.
- Purples.
- Thrombocytopathy.
- Cramps.
- Burning at the injection site.
- Diplopia.
- Vomiting, nausea.
- Abdominal pain.
- Diarrhea.
If the drug is administered infusion, then dosages of 300-600 mg should be used. This amount of medicine is administered once a day for half an hour.
Tableted or capsule "Berlition" is indicated to be taken once a day for 1 piece. Chewing units should not be allowed. Reception should be carried out on an empty stomach, at least half an hour before meals.
Reviews on "Espa-Lipon" and analogues
Reviews about the use of the considered drugs are quite rare, since they are used, as a rule, not for monotherapy, but as part of a comprehensive treatment. Patients note the effectiveness of drugs in the treatment of diabetic type polyneuropathy. The tool quickly enough allows you to eliminate the clinical manifestations of the disease - loss of sensitivity, cramps, pain in the feet and legs. There are also reviews about the successful use of thioctic acid preparations as elements of the complex therapy of atherosclerosis. Negative symptoms after the use of drugs develops quite rarely, the occurrence of heartburn and nausea is most often noted. In general, the drug is well tolerated.
We reviewed the instructions and analogues of Espa-Lipon.