Dosage form
The medicine "Cardiomagnyl" is supplied in two types of tablets - the first in the shape of a heart, the second are oval. All pills are white.
Structure:
Active substance:
- Magnesium hydroxide - 75/150 mg (in 1 tablet, respectively)
- Acetylsalicylic acid - 15/30 mg (in 1 tablet, respectively)
Excipients:
- Hypromellose
- Corn starch
- Magnesium stearate
- Potato starch
- Microcrystalline cellulose
- Talc
pharmachologic effect
The drug "Cardiomagnyl" is an NSAID and antiplatelet agent. The mechanism of action of the drug is as follows - acetylsalicylic acid confidently and irreversibly inhibits cyclooxygenase enzymes, after which the synthesis of thromboxane A2 is interrupted, and platelet aggregation is also inhibited . In addition, it is generally accepted that acetylsalicylic acid has other mechanisms of action on platelet aggregation, which can significantly expand the scope for the use of this drug. Acetylsalicylic acid, in addition, has analgesic, anti-inflammatory and antipyretic effects.
Magnesium hydroxide is able to protect the gastrointestinal mucosa from the harmful effects of acetylsalicylic acid.
Indications for the use of the drug “Cardiomagnyl”
The instruction says that cardiomagnyl should be taken only after consulting a doctor.
- For the prevention of CVD and DOS, in the presence of risk factors
- For the prevention of recurrence of myocardial infarction
- For the prevention of relapse of blood vessel thrombosis
- For the prevention of thromboembolism after surgery
- For the treatment of unstable angina
Side effects of the drug “Cardiomagnyl”
The instruction speaks of several types of side effects, which may vary depending on the body systems.
Possible side effects from the use of the drug from allergic reactions:
- Anaphylactic shock
- Quincke's edema
- Hives
Possible side effects from the use of the drug from the gastrointestinal tract:
- Heartburn
- Vomiting
- Nausea
- GI bleeding
- Abdominal pain
- Increased activity of liver transaminases
- Esophagitis
- Gastrointestinal ulcers
- Stomatitis
- Colitis
- Strictures
- Erosion of the upper sections of the gastrointestinal tract
Possible side effects from the use of the drug from the respiratory system:
Possible side effects from the use of the drug from the hematopoietic organs:
- Bleeding increase
- Anemia
- Neutropenia
- Thrombocytopenia
- Hypoprothrombinopenia
- Aplastic anemia
- Agranulocytosis
- Eosinophilia
Possible side effects from the use of the drug from the central nervous system:
- Drowsiness
- Dizziness
- Insomnia
- Headache
- Intracerebral hemorrhage
- Noise in ears
Contraindications of the drug “Cardiomagnyl”
The instruction includes the following types of contraindications:
- Intracranial hemorrhage
- Bronchial asthma
- Thrombocytopenia
- Vitamin K deficiency
- Hemorrhagic diathesis
- Bleeding tendency
- Exacerbation of gastrointestinal erosion
- Gastric ulcer exacerbation
- GI bleeding
- Methotrexate
- Pregnancy
- Lactation
- Under 18 years old
- Sensitivity to aspirin and other substances that are components of the drug
Medicinal interaction of the drug “Cardiomagnyl”
The instruction says that the combination of anticoagulants, antiplatelet drugs and thrombolytics with acetylsalicylic acid can cause an increased number of bleeding.
A combination of methotrexate with acetylsalicylic acid can cause quite a few different complications from the blood forming organs.
The combination of ibuprofen and acetylsalicylic acid worsens the positive effect of the latter on life expectancy.
The combination of alcohol and acetylsalicylic acid can increase the risk of gastric bleeding.