Regardless of the form of release, "Lazolvan" refers to a group of mucolytic (diluting) agents with the active substance in the composition - ambroxol. Mucolytic drugs are used to dilute with difficulty exhausting sputum. If the children have a strong cough, and sputum due to viscosity leaves with great difficulty, in such cases just this type of medicine comes to the rescue.
Children's "Lazolvan" is available in the form of syrup, which greatly facilitates the use of the drug by children, even in infancy.
Release form for use in children
"Lazolvan" in syrup is presented in the form of a transparent, almost colorless and slightly viscous liquid having the taste of wild berries, strawberries or citrus fruits. The drug is available in bottles of 100 and 200 ml, packed in a cardboard box. Each pack contains a 5 ml measuring cup.
Other forms of release
In addition to syrup, there are also other forms of release of "Lazolvan": a solution for inhalation, lozenges, tablets and capsules ("Lazolvan Max"). For the treatment of inflammatory diseases of the nose there is "Lazolvan Reno." However, it contains another active substance.
What is the composition of "Lazolvan" for children?
Structure
The active component of the drug of any form of release is ambroxol in the form of hydrochloride.
The medicine in syrup is available in two types of concentrations:
- 5 ml of the syrup form contains 15 mg of the active ingredient in the form of ambroxol hydrochloride;
- 5 ml of the syrup form contains 30 mg of the active ingredient in the form of ambroxol hydrochloride.
Auxiliary components: sorbitol, benzoic acid, flavorings (vanilla, berry), glycerol, hydroxyethyl cellulose, distilled water, potassium acesulfame.
Ambroxol hydrochloride, which is an active substance in children's “Lazolvan,” has an action that increases the secretion of bronchial mucus, a mucolytic (diluting) effect of mucus, activates the functions of the mucous membrane of the respiratory tract, and helps normalize the functioning of the pulmonary alveoli. All this activates the process of mucociliary mucus in the respiratory tract. Viscous sputum liquefies, and expectorant properties lead to the removal of excess mucus from the bronchial sections through a cough reflex.
With a dry cough, children's "Lazolvan" helps to improve expectoration of sputum, and with a wet cough, it helps to effectively clear the airways of excess mucus.
In addition, the active substance "Lazolvana" - Ambroxol hydrochloride - improves the penetration of antibiotics into the lungs and bronchi, thereby enhancing their effect and increasing the effectiveness of antibiotic therapy.
Pharmacokinetics
With the oral route of administration, it has the ability to be rapidly absorbed in the digestive tract. In plasma, the maximum concentration of the active substance is reached within 1.5 hours. The therapeutic effect of "Lazolvana" occurs due to the accumulation of the drug in the bronchial and pulmonary tissues.
In the course of clinical studies, no significant concentrations of the active substance in other tissues and organs were detected.
Metabolization occurs in the liver. Up to 95% of the active substance of the drug is excreted by the kidneys from the body. The elimination half-life is from 8 to 12 hours. The medicine does not have the property of accumulation in tissues and organs.
Indications for use
Indication for the use of children's "Lazolvan" is a cough with difficult viscous sputum and difficulty in secreting bronchial mucus.
"Lazolvan" can be used for children and adults of all ages. The dosage and choice of dosage form is determined by the doctor depending on the age of the patient, as well as the complexity of the course of the disease.
The area of application of the drug is inflammation of the respiratory tract with a wet or dry cough.
According to the instructions for use, "Lazolvan" for children is prescribed for:
- chronic bronchitis;
- acute and obstructive bronchitis;
- pneumonia;
- cystic fibrosis;
- bronchial asthma;
- neonatal respiratory distress syndrome of children;
- infections complicated by inflammatory processes of the respiratory tract.
Features of use and contraindications
At what age can a Lazolvan children's be used?
The drug with a proportion of 15 mg / 5 ml is approved for use by children of any age.
For babies up to the year of appointment, they are made in a limited manner, since they have difficulty coughing.
"Lazolvan" in syrup with a proportion of 30 mg / 5 ml is allowed for use by children over 6 years.
The list of contraindications "Lazolvan" is small:
- for the treatment of children under 6 years old, the only recommended form of release is syrup. For this age group of patients, a composition is released at a concentration of 15 mg / 5 ml;
- severe renal and hepatic diseases;
- fructose intolerance;
- hypersensitivity and intolerance to the components of the drug.
Dosage "Lazolvana" for children
The maximum daily dose of the drug for use in children under 12 years old is from 30 to 45 grams, which is recommended to be divided into 2-3 daily doses, depending on the complexity of the disease, the age of the patient, and the severity of the cough syndrome
It is taken orally. And usually regardless of the meal.
For the correct dosage, a measuring cup is enclosed in each package of Lazolvan cough syrup.
Dosage of the syrup form of the drug
- Pediatric patients under two years old - 2.5 ml 2 times a day.
- Pediatric patients from 2 to 6 years old - 2.5 ml 3 times a day.
- For children from 6 to 12 years old - 5 ml of syrup with a concentration of Ambroxol 15 mg / 5 ml or 2.5 ml with a concentration of Ambroxol hydrochloride 30 mg / 5 ml. Take 2-3 times a day.
- For children over 12 years old - 10 ml of syrup with a concentration of ambroxol 15 mg / 5 ml or 5 ml with a concentration of ambroxol 3 times a day.
The duration of the course is determined by the doctor. While maintaining the symptoms of the disease and the absence of the necessary effect after 4-5 days, you must consult a doctor.
Is the children's "Lazolvan" completely safe with a dry cough?
Side effects
Digestive system: nausea, a decrease in the sensitive function of the oral cavity, less often dyspeptic symptoms, vomiting, diarrhea, spasmodic pain in the epigastric region, a feeling of dry mouth are possible.
Immune system: rarely - skin allergic manifestations, anaphylactic shock, hypersensitivity, skin itching.
Nervous system: violation of taste sensitivity.
The frequency of adverse episodes is from 0.1% to 10%, which is an extremely rare sporadic cases, the clinical connection with the use of "Lazolvan" which is not always proven.
"Lazolvan" enhances the action of certain antibacterial compounds by increasing their penetration into the bronchial secretion. These include, for example, amoxicillin, cefuroxime, erythromycin. There are no other clinically recorded cases of interaction with drugs.
special instructions
"Lazolvan" is an antagonist of antitussive drugs (drugs to suppress the cough reflex, prescribed for dry unproductive cough), which make it difficult to discharge sputum. Accordingly, it is not recommended to combine Lazolvan with those.
Patients with severe skin pathological processes, such as Lyell syndrome or Stevens-Johnson syndrome, at the early stage of the disease can respond to taking the drug by fever, body pain, increased cough, sore throat. There are only sporadic cases of Lyell syndrome and Stevens-Johnson syndrome, which, quite possibly, simply coincided with the start of taking ambroxol-containing drugs. A clinically determined association between these syndromes and drug administration has not been proven.
At the first signs of the above syndromes, medication should be stopped immediately and immediately seek emergency medical help.
The appointment of the children's "Lazolvan" during pregnancy takes place in medical practice and is carried out quite often.
Important Notice
Important! Usually the instructions do not say about this, but it should be remembered that it is not recommended to take "Mucosolvan" and similar mucolytic drugs at night. It is easy to guess that the intensifying cough reflex and sputum discharge will simply not let the baby sleep, or in a dream the baby simply will not be able to cough up sputum normally, and all of it will remain in the respiratory tract in a diluted state.
Pediatric patients after 12 years of age do not need to use the syrup form of the drug. Pills are great.
Reviews on the effectiveness and feasibility of the drug
The drug is considered quite safe.
A rather significant amount of real reviews about “Lazolvan” comes from the parents of preschool children, since it is this age group that is most susceptible to diseases of a viral-infectious nature. Many disputes are caused precisely by the advisability of prescribing mucolytic drugs at a young age. There are many doubts about the need to dilute sputum in principle, since, in simple terms, children still do not know how to "cough" cough and actually can not effectively cough up liquefied sputum. Accordingly, the intended purpose of the drug is not respected, and children take it in vain.
No fewer parents nevertheless observed a progressive therapeutic effect of the drug, when at the beginning of Lazolvan therapy, after 3-4 days, a dry and unproductive cough became wet, mucus was observed to go away, and the child's condition improved markedly.
Also, in spite of the fact that Lazolvana syrup has a pleasant fruity sweet aroma and taste, many parents had difficulty in persuading the child to take the medicine. Moms and dads had to resort to tricks and, for example, add medicine to a bottle with compote or mixture, in a cup with juice.
Among patients, there were potential doubts about the safety of the drug in terms of addiction. Nevertheless, there is not a single clinical case or review of a real addiction to the mucolytic effect of the drug.
There are a lot of positive and negative reviews about the effectiveness of the drug.
It is worth noting that the drug is designed to achieve a visible therapeutic effect in the first days of use. If, after 4-5 days, the condition and symptoms have not changed for the better, the drug should not be continued, but it is necessary to get medical advice on changing treatment tactics.
Reviews about the side effects of the drug
Reviews of patients and parents of children about "Lazolvan" usually speak in favor of good tolerance to the drug. Side effects have extremely rare manifestations, and their main part falls on the gastrointestinal reactions. This is due to the proximity of the cough and vomiting centers in the human brain. Stimulation of one of them affects the neighboring one.
Although the instruction for the drug does not highlight any particularities in the use of the drug in relation to meals, in order to avoid unpleasant side effects from the gastrointestinal tract in the form of vomiting, it should be taken half an hour before or one hour after a meal.
Among the few side effects after inhalation with "Lazolvan", judging by the reviews, there were also cases of rashes on the skin or flushing of the skin.
It is noted above that the drug is quite safe and side effects are extremely rare. Nevertheless, its independent appointment is not recommended. This is especially true for children in the infancy.
Analogs of children's syrup "Lazolvan"
Ambroxol is a fairly popular active ingredient in expectorant drugs. The pharmacy market is represented by a huge number of drugs of various forms and dosages containing ambroxol hydrochloride. Here is an example of just a few: Ambrobene, Ambroxol, AmbroHEXAL, Lazongin, Bronchoxol, Neo-Bronchol, etc. Many of the analogues are also available in different forms, including those recommended for children .
We reviewed the instructions for use for the children's "Lazolvan."