Pathologies of the gastrointestinal tract are often caused by a lack of pancreatic secretion. At the intestinal stage, digestion is carried out using enzymes produced by the mucous cells of the small intestine and pancreas.
When a deficiency of enzymes is observed, a violation of the entire digestive process occurs. Their number can be restored through the use of drugs. A commonly used drug is Creon. Reviews about him are abundant. It helps to restore intestinal microflora and stabilize the digestive process.
pharmachologic effect
The drug is one of the enzyme preparations, the main pharmacological sign of which is an increase in the digestive tract. The drug is recommended to be taken both for chronic inflammation in the pancreas, and for genetic pathologies (cystic fibrosis).
The medication is widely used in the oncological field (in the treatment of pancreatic cancer or at the rehabilitation stage after surgery).
Drug properties
The enzyme agent is used to improve the digestion process in children and adults, improve the condition of the digestive organs as a whole. âCreonâ replenishes pancreatic enzymes, helps to normalize the digestibility of substances that are obtained with food in the small intestine. Compensates for the deficiency of the pancreas, promotes tissue repair during gastric resection, ensures the disintegration of starch and lipid molecules, and facilitates the breakdown of proteins, carbohydrates and fats.
This confirms the instructions for use for the âCreonâ product. Price and reviews are of interest to many.
Indications for use
The medication is used for replacement therapy in the following situations:
- with chronic pancreatitis;
- with cancer pathology of the pancreas;
- with pancreatectomy;
- with insufficiency of the endocrine functioning of the pancreas;
- with Schwachmann-Diamond syndrome;
- with neoplasms accompanying ductal obstruction;
- with a decrease in the process of formation of enzymes in elderly patients.
For therapeutic purposes in case of digestive dysfunction, âCreonâ is used in case of:
- defects of the terminal intestinal department;
- biliary obstruction;
- cirrhosis of the liver;
- cholestatic hepatitis;
- fragmented gastric resection;
- progressive multiplication of bacteria in the small intestine;
- the presence of cholecystectomy;
- total gastrectomy.
It is advisable for small patients to take medicine to restore the microbiological environment of the gastrointestinal tract after manifestations of diarrhea.
The medication âCreonâ is prescribed as an additional agent, which helps to facilitate the digestive process, if a personâs nutrition is improper (excessive consumption of high-calorie and fatty foods).
"Creon" is prescribed to patients who underwent surgical intervention to partially remove the stomach or intestines during recovery.
Mode of application
The drug "Creon" must be taken orally after or with food. The medicine must be swallowed, and then washed down with enough water.
The number of doses and dosage of the drug is determined by a specialist based on individual data, based on the patientâs diagnosis and the specifics of the pathology.
The dosage of the drug for cystic fibrosis is determined by the calculation for the content of lipase:
- patients under four years of age - per kilogram of weight up to 1000 units;
- over four years old - per kilogram of weight 500 units.
The medicine is used at every meal. If you have difficulty swallowing the capsule, it is allowed to open and pour the granules into liquid food.
Adults are prescribed the drug every day in the amount of 10,000-25,000 units. per kilogram of body weight, depending on the specifics of the pathology.
So it says in the instructions. Price and reviews for "Creon 10000" will be presented below.
If there are violations of the functioning of the pancreas, then the dosage of the medicine is determined based on the results of the course of the disease and steatorrhea. You need 10,000 units per kilogram of weight, so you should buy "Creon 10000".
In the instructions for use, price and reviews are not indicated.
To prevent constipation caused by taking the product, you need to drink plenty of fluids throughout the day.
Changing the dosage yourself is not allowed, as this can lead to negative consequences.
Release form and composition
The drug "Creon" is made in the form of soluble gelatin capsules. Their active component is pancreatitis, excipients: hypromellose phthalate, macrogol, dimethicone, triethyl citrate, alcohol, paraffin and titanium dioxide.
Depending on the lipase content, the drug may have a variety of:
- "Creon 10000" (active substance 150 milligrams, lipase activity is 10,000 units, 600 units of protease, 8,000 units of amylase). It is produced in an amount of 25 or 10 pieces in an aluminum plate, or in an amount of 50 or 20 pieces in a plastic bottle. The average price of a bottle with 20 capsules is 290 rubles.
- "Creon 25000" (active substance 150 milligrams, lipase activity is 25000 units, 18000 units of amylase, 1000 units of protease). It is produced in an amount of 25 or 10 pieces in an aluminum plate or in an amount of 100, 50 or 20 pieces in a plastic bottle. Approximately 20 capsules cost 560 rubles.
- "Creon 40,000" (400 milligrams of active substance, 40,000 units - lipase activity, 25,000 units of amylase, 1,600 units of protease). It is produced in quantities of 100, 50 or 20 pieces in a bottle of plastic. The average price in pharmacies for 50 capsules is 1370 rubles.
This information is available in the instructions. According to reviews, "Creon 10000" differs from other drugs listed above only in dosage.
Interaction with other drugs
The interaction of the drug "Creon" with other medicines was not observed. Also, a test for simultaneous use with alcohol was not conducted. It is noted that the drug can slightly reduce the absorption of iron. If necessary, an additional intake of preparations containing iron is prescribed. Also, "Creon" can reduce the influence of "Acarbose".
Side effects
According to reviews of "Creon", the most common side effects of using the drug, which alter the functioning of the gastrointestinal tract:
- Bloating.
- Nauseous reflexes.
- Pain in the abdomen.
- Diarrhea.
- Vomiting
- Constipation.
- The formation of strictures in the field of the ileocecal department (if large doses are taken for a long time).
Also, the instructions and reviews of "Creon" confirm that such side effects as:
- From the skin integument (especially often in childhood): allergic rashes, itching, atopic dermatitis, urticaria.
- From the side of immunity: sensitivity to the components of the drug, anaphylactic reaction.
- Genitourinary system: if used for a long time in large doses, hyperuricosuria occurs.
It is very important to know that if side effects occur due to taking the medicine, you must immediately stop treatment and seek the advice of a specialist.
The doctor may make a change in dosage or prescribe another drug to continue therapy.
But before taking, you should carefully study the instructions. According to reviews, "Creon 25000" causes side effects as often as drugs in other dosages.
Overdose
If the dosages are significantly exceeded, this can cause pronounced negative manifestations. To eliminate the negative reaction, symptomatic treatment is used. With a regular dosage violation, the composition of the blood can change and hyperuricosuria and hyperuricemia develop.
If negative symptoms are suspected due to exceeding the dose, biological material should be examined in the laboratory.
An overdose can have the following consequences:
- increased salivation;
- bouts of uncontrolled nausea and vomiting;
- signs of intestinal distention and constipation;
- discomfort in the gastrointestinal tract of varying intensity;
- allergic manifestations (only if the patient has a high sensitivity to the drug);
- sharp bouts of pain localized in the abdomen.
Contraindications
The drug "Creon" is undesirable to use:
- with the inflammatory process of the pancreas of an acute nature at the initial stage of the development of the disease;
- with intolerance to the components of the drug;
- with chronic pancreatitis.
As already noted, the price is not indicated in the instructions. Reviews of analogues and prices of analogues of "Creon" are presented below.
Medicines of a similar action and their cost
If there is no possibility of using âCreonâ due to contraindications, price and other reasons, the specialist will certainly offer the patient an analogue that matches his properties.
There are drugs that are similar to Creon 10000 in active content. In addition, there are drugs that are similar in mechanism of action.
The first case includes the following drugs: Hermitage, Gastrenorm forte, Mikrazil, Vestal, Uni-Festal, Mezim Forte, Hepatophyt Forte, etc. For example, the price of Mikrasima "For twenty drops is half as much. Hermitage is an even cheaper means.
All drugs should be prescribed by a doctor, especially if the patient refuses âCreonâ because of its cost: cheap analogues can be found in the pharmacy, but only a specialist should recommend them.
Analogs of the second type are: Enterosan, Stabilin (it has proved itself well, judging by the reviews), Normoenzyme, Festal, Nygeda (a drug that stands out from the damask nigella seed), Enzistal.
Itâs easy to find cheap analogues. So âMikrazimâ costs 250-270 rubles, âMezimâ - 191 rubles, âFestalâ - 170-180 rubles, for packing âPanzinormâ you need to pay 120-140 rubles, âPancreatinâ costs up to 50 rubles.
Reviews about "Creon" from doctors and patients
Experts believe that "Creon" is the "gold standard" in the treatment of acute and chronic pancreatic pathologies. He repeatedly proved high efficiency in the practice of doctors. Side effects are noted in isolated cases. It is used in both surgical and therapeutic practice.
This tool is quite popular, is discussed by patients in various forums. In particular, there are often reviews about the treatment of Creon 10000 infants, and they are ambiguous. Some mothers say that therapy helps to quickly eliminate all problems, while others say that they did not notice any benefit. Nevertheless, the drug does not harm the child.
Patients are actively discussing in reviews "Creon 25000", which is prescribed for digestive disorders. Numerous reviews about him on the forums are also rather mixed. Some patients take it in case of severe digestive disorders, while the majority take it in situations when there are problems of digestion of "heavy" food. However, this makes it possible to improve the patient's condition with insufficient endocrine pancreatic function and other disorders.
We reviewed the tool "Creon" instructions, price and reviews.