In the instructions for use of "Flucostat," the manufacturer indicates that the drug belongs to the class of antifungal. The drug is often prescribed to women with thrush caused by colonies of fungi from the genus Candida. The medication is available in the form of capsules, convenient for everyday use. The manufacturer draws attention to the fact that "Flucostat" must be used following the accompanying documentation and the doctor's recommendations, otherwise adverse reactions of the body are possible.
general information
You can buy the drug only in a licensed pharmacy. On the shelves of such points you can see cardboard boxes, inside of which there are capsules "Flucostat" and instructions for them. Also, the medication is available in the form of candles, a solution for infusion. In any form, the product is intended to inhibit the activity of pathological fungi. Before use, you must familiarize yourself with the contents of the accompanying documentation, where the manufacturer lists contraindications, indications, rules of use and possible negative consequences from its use.
In the instructions for use of "Flucostat", the manufacturer indicates the active substance, which provides the product with a pronounced effect - fluconazole. This compound belongs to the class of triazole and has proven itself in the fight against fungal infections. The substance belongs to the category of selectively acting. It inhibits the production of sterols in the fungal cell.
Dynamics
Many people know that "Flucostat" is effective for thrush, but they prescribe it for some other fungal diseases - this is evidenced by reviews. In the instructions for use of "Flucostat" it is mentioned that the active substance shows effectiveness not only with respect to fungi from the Candida genus, but also with a number of other pathological life forms. In particular, the drug is used for infection with Trichophyton, Microsporum, Cryptococcus. You can use the drug for diseases provoked by the fungi Histoplasma, Blastomyces, Coccidioides.
Kinetics
According to the instructions, 1 capsule of "Flucostat" contains fluconazole, absorbed shortly after taking the drug. The bioavailability of the active ingredient is estimated at an average of 90%. The maximum concentration of a substance in blood plasma when using the drug on an empty stomach in an amount of 150 mg is 10% less than when injected into a vein.
To achieve maximum concentration in the circulatory system, it takes from 30 minutes to an hour and a half. In the instructions for use of "Flucostat", the manufacturer mentions the absence of dependence on the quality of absorption of the active component and food intake. The content of fluconazole in plasma is proportional to the volume of medication received in the body.
A stable concentration of the active substance in the circulatory system is achievable by the fourth or fifth day of regular use, if the substance is used once a day, as recommended by the instructions for "Flucostat".
Application features
It is possible to achieve a stable concentration by the second day of the therapeutic program if you use a loading dose on the first day of treatment, that is, twice as much as 150 mg prescribed per day according to the instructions. "Flucostat" is taken in the amount of two capsules. The volume of distribution in this case is close to the content in the body of the diseased fluid. With proteins, the active component enters into strong bonds only by 11-12%.
The active component is characterized by good penetration: fluconazole is found in a variety of body fluids. In the sputum secreted by the salivary glands, the substance is observed in an amount similar to the content in the blood plasma. According to the instructions, the use of "Flucostat" is allowed for meningitis provoked by fungal infection - studies have shown that the active substance in the fluid of the spinal cord is observed at a concentration 20% lower than in blood plasma.
Concentrations and Nuances
In the instructions for use of "Flucostat," the manufacturer mentions that in the products secreted by the sweat glands, in the skin, the active compound is contained in a higher concentration than in blood serum.
The half-life of fluconazole is estimated at 30 hours. Mostly this process is realized by the kidneys. Up to 80% of the substance leaves the body with urine, without undergoing transformation reactions. The clearance of the active compound is proportional to creatinine. The instructions for use of “Flucostat” specify that studies did not reveal the products of fluconazole transformation reaction in the circulatory system of patients.
Alternative release forms: solution
Sometimes the doctor prescribes a solution, not Flucostat capsules. Instructions for use on this form also indicate that the substance belongs to the class of antifungal. The tool has a pronounced, strong effect - this is indicated by the manufacturer. The same is confirmed in numerous reviews.
Both patients who used Flucostat and doctors who often recommend it to their clients respond positively to the medication. One of its important features is selectivity of action. Under the influence of the active substance, the processes of synthesizing vital substances are suppressed only in pathological cells.
In the form of a solution, according to the instructions, "Flucostat" is used for the same pathological forms of life as those mentioned above for capsules. The drug is effective if opportunistic mycosis is established. You can use the solution in some forms of endemic mycoses.
Technical points
The Flucostat instructions specify that soon after intravenous infusion, fluconazole is observed in a variety of fluids, tissues of the patient's body. The substance is characterized by high penetration. The concentration in the blood serum depends on the amount of medication used. In sputum and saliva, the indicators are approximately the same as in serum. In the fluid of the spinal cord, the content of the active substance of the drug is estimated at 80% relative to the inherent blood serum.
A stable stationary concentration of fluconazole when using "Flucostat", according to the instructions for injection into a vein, is achievable after 4-5 days from the start of the course. This applies to the use of the drug in a single dose every day. On the first day of the program, you can take two doses of "Flucostat." In this case, by the second day of treatment, stable indicators of the equilibrium concentration in the blood serum of the active compound can be achieved.
The volume of distribution during intravenous administration of the drug is close to the volume of fluid present in the patient's body. About 1/10 of the fluconazole patient entering the body comes into contact with plasma proteins.
The nuances of using
As in the instructions for the use of Flucostat capsules (1, 2 or 7 capsules in one package), the accompanying documentation for the drug produced in the form for intravenous infusion mentions that its excretion is carried out by the kidneys. Could not detect transformation products of the active compound in the peripheral blood. Up to 80% of fluconazole is eliminated in its original state. The clearance of the compound depends on creatinine.
For fluconazole, injected into the patient's body, the half-life is 30 hours.
What's on sale?
There are several formats for the production of the drug. In the pharmacy you can buy medicine packaged in a cardboard box. Inside the box contains instructions for use and Flucostat (150 mg and other dosage options).
Flucostat capsules are made in white. The products are opaque, filled with a powder of white or a shade close to it. In addition to fluconazole, additional compounds are present: lactose, starch, aerosil. A complete list of substances used by the manufacturer can be found in the accompanying documentation for the medication. Familiarizing yourself with it is especially important for people suffering from allergic reactions to substances used in the pharmaceutical industry.
Instructions for use with Flucostat 150 mg are almost identical to the accompanying documentation for capsules containing 50 mg of the active compound. You can visually distinguish different forms of release by color - a less concentrated version is painted in a light shade of brownish or pink. Inside the capsule is also filled with white powder.
More views?
In addition to these options, "Flucostat" is available in the form of suppositories, a solution for injective administration. For infusion, a clear liquid is used. The drug has no color. One bottle contains 1 ml of the substance, in it - 100 mg of the active compound. As additional components, the manufacturer uses special purified water and sodium chloride.
There are Flucostat candles on sale. Instructions to them indicate that the drug is intended for local use. The list of additional connections used by the manufacturer can be found by reading the official accompanying documentation.
The nuances of consumption
According to the instructions for use, "Flucostat" for thrush and other fungal diseases can be started to be used until the results of laboratory tests, including sowing, are obtained. It is allowed to use the medication in combination with some other drugs. If a patient uses diabetes medications, fluconazole may increase their effectiveness.
"Flucostat" does not affect the effectiveness of hormonal contraceptives. The opposite effect is possible. If the patient takes hormonal birth control, you may have to increase the dosage of Flucostat.
Mutual influence
The instructions for "Flucostat" 150 mg (dosage of fluconazole in one capsule) indicate that the combination with warfarin can cause an increase in the length of time of prothrombin. On average, the difference relative to the norm is estimated at 12%. This makes it necessary to control the time of prothrombin in individuals to whom Flucostat was prescribed and coumarin substances to correct blood coagulation.
The use of oral hypoglycemic agents against the background of "Flucostat" may cause an increased half-life. With thrush, according to the instructions, "Flucostat" can be used by combining with sulfonylurea products, but only when taking into account the likelihood of hypoglycemia. The patient should know how this condition manifests itself, as well as what first aid is needed.
When using "Rifampicin" and "Flucostat" there is a chance of decreasing the half-life of the antifungal substance. In order for the therapeutic course to be effective, it is necessary to control the dosage of drugs, increasing, if necessary, the volume of "Flucostat".
Note
According to the instructions, “Flucostat” (for men and women, the drug is recommended for fungal infections, thrush, meningitis) can be used in combination with preparations containing phenytoin. But this takes into account that the concentration of the second can increase sufficiently to affect the clinical picture. If the patient needs to combine these funds, the therapeutic course requires you to monitor the content of phenytoin in the blood serum. If this becomes necessary, you need to adjust the dosage of this drug.
Some patients talk about combination therapy with antifungal and suppressing the immune system - such information can be seen in a number of reviews. According to the instructions "Flucostat" can be combined with cyclosporine. Persons undergoing such complex treatment noted that the doctor regularly sent for blood tests. This kind of therapy can be prescribed after a kidney transplant. If 200 mg of fluconazole or a larger amount is ingested daily, this can trigger an increase in the content of cyclosporine.
Is it worth using?
In general, in their responses about the effectiveness of Flucostat capsules, patients who used this drug note its effectiveness, effectiveness, quick and pronounced directed action. Many also recognize that the price of a medicine, although high (from 200 rubles per capsule), is fully justified - the use of the drug in a course allows you to get rid of fungal colonies in a short time and regain your health.
From reports of individuals using Flucostat, it is clear that the drug is usually well tolerated. The negative consequences of drinking were more often encountered by patients who used the medicine without consulting a doctor, at their own discretion. In the instructions, the manufacturer of the medication indicates the inadmissibility of self-treatment with an antifungal drug. "Flucostat" is intended for use only after consulting a doctor.
Features and Combinations
Sometimes the need for therapy with the medicine "Flucostat" occurs in people taking fairly large volumes of theophylline. In this situation, as well as in the presence of other factors that can provoke theophylline poisoning, if necessary, the appointment of combination therapy, the patient's condition is put under special control. The main task is to notice an overdose of theophylline in the shortest possible time. Tests have shown that the simultaneous use of "Flucostat" and this drug provokes a slowdown in its plasma clearance.
Sometimes patients are prescribed a combination of fluconazole, cisapride, terfenadine. In clinical practice, there are cases when combination therapy became the cause of a negative response from the cardiac system. There is a risk of arrhythmias like pirouette.
The combination with zidovudine may be the reason for the increased concentration of this compound in the blood serum. The phenomenon is due to the inhibition of the process of transformation into metabolites.
When using Flucostat and drugs containing rifabutin, one may encounter an increase in the concentration of this drug in the blood serum. According to medical statistics, such a combination can provoke uveitis. To avoid the negative consequences of complex therapy, it is important to monitor the condition of patients.
If fluconazole is used during treatment with midazolam, the probability of negative psychomotor effects becomes higher. When combined with tacrolimus, the risk to the kidneys increases, the risk of toxic effects on this organ is higher.
Solution: interaction features
Currently, there is no information about the possible incompatibility of the Flucostat solution and other pharmaceutical products. In the instructions for use, the manufacturer recommends not to mix the substance with any medications. An exception is a solution for infusion into a vein.
Too much!
If you use the product excessively, there is a risk of overdose. The patient's behavior becomes paranoid. There is a chance of hallucinations.
When an overdose is detected, gastric lavage is indicated. The doctor chooses drugs to eliminate the symptoms that are characteristic of a particular case. The main active substance of "Flucostat" is eliminated with urine. This process can be stimulated by forced diuresis. Blood dialysis, carried out within three hours after the use of "Flucostat", allows to reduce the content of the active component in the blood serum by about half.
What to replace: analogues
The instructions of "Flucostat" indicate that the main component that ensures the effectiveness of the medication is fluconazole. Medicines are based on it:
- "Fluconazole";
- "Diflason";
- "Mikosist";
- Diflucan.
If it is impossible to use the drug recommended by the doctor, the question of replacement should be agreed with the attending physician, explaining why the patient cannot take the medication that was originally selected. Only a doctor, evaluating the diagnosis and condition of the patient, can choose the best option. Self-replacement with analogues can be the cause of treatment inefficiency and the patient's condition worsening.
Based on the cost, the most affordable analogue of Flucostat is Fluconazole.
Features of use
In case of cryptococcal meningitis provoked by infectious processes in various organs and tissues, Flucostat should be taken in the amount of 400 mg on the first day. The course is continued, consuming 200-400 mg daily. The duration of therapy depends on the effectiveness - special tests are prescribed to detect it. Usually the course lasts at least one and a half months, sometimes reaches 8 weeks.
To prevent the recurrence of such a disease against AIDS, after the completion of the course of fluconazole, it is necessary to take 200 mg daily for a long time.
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