Prestarium contains arginine as the active ingredient in perindopril. Auxiliary components: copper chlorophyllin, lactose monohydrate, maltodextrin, magnesium stearate, hydrophobic colloidal silicon, glycerin, macrogol 6000, sodium starch glycolate (type A), titanium dioxide.
Prestarium. Description
The active component of the drug helps to increase the level of bradykinin, which provokes relaxation of blood vessels and an improvement in endothelial function. This plays a leading role in improving fibrinolytic blood balance and reducing cardiovascular remodeling.
Perinidopril is involved in the expansion of peripheral vessels and a decrease in their resistance. An increase in peripheral blood flow occurs without an increase in heart rate. The use of the medication helps to increase renal blood flow, but there are no changes in glomerular filtration rate .
The complex mechanism of action of the active component provides a decrease in high blood pressure.
Prestarium. Instruction Indications
The drug is prescribed for heart failure, arterial hypertension, as a prophylaxis in patients with cerebrovascular disorders of repeated stroke, to prevent cardiovascular complications in individuals with established stable coronary artery disease. Medication "Prestarium" instruction allows you to take a long period. This reduces the likelihood of heart failure and myocardial infarction.
Prestarium. Instruction Dosage
The drug is taken orally before meals once a day, recommended in the morning. The dosage is selected individually taking into account the indications and blood pressure level. 5 mg tablets are to be divided, 10 mg - cannot be divided.
For arterial hypertension, the drug Prestarium recommends taking the drug with 5 mg. A combination of the drug with antihypertensive drugs of other classes is allowed.
If well tolerated, if necessary, the doctor may prescribe a gradual increase in dosage from 5 to 10 mg.
In heart failure, experts recommend starting the drug with 2.5 mg before meals once a day in the morning. After two weeks with good tolerance, the dosage can be increased to 5 mg.
With insufficient effectiveness from taking the drug, it is possible to prescribe additional indapamide or a fixed combination of perindopril and indapamide in the drug Prestarium Arginine Combi.
Long-term therapy reduces the likelihood of heart attack and heart failure.
To prevent cardiovascular complications in patients with established coronary artery disease, treatment begins with a dosage of 5 mg per day in the morning. After two weeks with good tolerance, the dosage gradually increases to 10 mg.
"Prestarium" 10 mg is prescribed one tablet during prolonged therapy to patients with established coronary heart disease, regardless of age, concomitant pathology and additional therapy.
The drug is contraindicated in case of hypersensitivity to any of the components, history of angioedema.
Various forms of medication, including Prestarium A, are not recommended for pregnancy and lactation.
An overdose of the drug manifests itself in the form of arterial hypotension, tachycardia, circulatory shock, electrolyte imbalance, renal failure, bradycardia, anxiety, and hyperventilation. In this case, the patient must be hospitalized and provide him with constant medical supervision. Treatment is selected according to the severity of the symptoms. As a rule, gastric lavage and the administration of enterosorbents are prescribed as first aid.