The medication "Noliprel" refers to the category of combination drugs. The active substances are indapamide and arginine perindopril. Components have the ability to mutually reinforce each other's action. While taking the medicine, there is a decrease in filling pressure in the right and left heart ventricle, an increase in cardiac index and ejection, an increase in peripheral muscle blood flow, and a decrease in the total resistance of the vessels (peripheral).
Means "Noliprel". Indications for use
The medication is prescribed for essential hypertension . The drug is recommended for patients with type 2 diabetes mellitus and high blood pressure to reduce the risk of macrovascular complications and the development of cardiovascular pathologies and microvascular manifestations from the kidney system.
Dosage "Noliprel"
The medication is prescribed a tablet once a day inside. It is advisable to drink the drug in the morning on an empty stomach. In diabetes mellitus and arterial hypertension amid satisfactory tolerance, an increase in dosage to two tablets is allowed. For elderly patients, the appointment of a medication is carried out after the diagnosis of renal function and pressure control.
Means "Noliprel". Instructions for use. Side effects
Very rarely, on the basis of therapy, disorders of the hematopoietic system and lymph flow occur. In particular, hemolytic anemia, thrombocytopenia, neutropenia, agranulocytosis are noted. Often there is dizziness, asthenia, pain in the head, paresthesia. In some patients, confusion, lability in mood, and sleep disorder are noted. The negative effects of treatment with Noliprel include instructions for tinnitus, visual impairment, orthostatic hypotension. In rare cases, a syncope may occur. The medication provokes a heart attack, angina pectoris, dry cough, bronchospasm, rhinitis, eosinophilic pneumonia, epigastric pain. During therapy, bradycardia, atrial fibrillation, constipation, nausea, skin rash are noted.
Against the background of treatment, angioedema, erythema multiforme, loss of appetite, dry mucous membrane in the mouth, taste disturbances, hepatitis, muscle spasms are sometimes observed. In rare cases, patients experience increased sweating, asthenia, impotence, and acute renal failure.
The medicine "Noliprel." Instructions for use. Contraindications
Do not take the drug in the presence of anamnestic data on angioedema, with stenosis in the arteries of the kidney (unilateral or bilateral), renal failure of the pronounced course. The drug "Noliprel" instructions for use does not allow reception with hypersensitivity. Do not use the medicine for decompensated untreated heart failure. Do not prescribe medication to patients on hemodialysis, pregnant and lactating. Contraindicated in children. It is not recommended to take the drug in combination with potassium-sparing diuretic drugs.