Lotion "Belosalik" is a drug with which to treat the dermis. It is one of the corticosteroids. The drug is produced in three forms: lotion (bottles of 50, 20 and 100 milliliters), ointment (tube of 30 grams) and spray. It has a hormonal nature. This article will focus on such a dosage form as a lotion.
Composition and form of release
Belosalik Lotion is a solution for external use. One gram of the drug contains 0.64 mg of betamethasone dipropionate, 20 mg of salicylic acid. Excipients are: hypromellose 4000 cps, disodium edetate, sodium hydroxide, isopropyl alcohol, purified water.
Pharmacological effect
According to the instructions for the lotion, “Belosalik” is a combined product whose action is based on the components that make up the composition. It has antiproliferative, antiallergic, local hypothermic, antimicrobial, immunosuppressive, antifungal, keratolytic, vasoconstrictive, decongestant and anti-inflammatory effects. It inhibits the release of inflammatory mediators, prevents the accumulation of neutrophils on the edges, reduces the exudate of inflammation and the production of cytokines, and reduces macrophage migration, as a result of which granulation and infiltration processes are also reduced.
The presence of hydrochloric acid in the composition allows you to soften the skin, eliminate the stratum corneum and contributes to a greater depth of penetration of the main components of the product.
Lotion, that is, a solution with a fat-free base, is well distributed on the skin surface, does not dry and does not stick hair, does not leave noticeable marks, produces a cooling effect on the skin.
How to correctly apply the lotion "Belosalik"? Consider this below.
Pharmacokinetic features
The absorption of betamethasone can change under the influence of various factors (skin condition in general, violation of the integrity of the epidermal cover, the presence of inflammation). If there is mechanical damage and inflammation of the skin, then absorption increases. Systemic absorption after topical application of the lotion ranges from 12% to 14%. About 64% of the active component binds to blood plasma proteins. Betamethasone metabolism occurs in the liver. Metabolites are excreted mainly with bile, about 5% - together with urine.
If salicylic acid is applied to the skin under an occlusive dressing, the highest plasma concentration is observed after five hours. Acid in an amount of 6% is excreted unchanged with urine, the rest is excreted in the form of metabolites with bile.
Indications
Lotion "Belosalik" is used for:
- eczema (especially chronic);
- psoriasis
- ichthyosis;
- neurodermatitis diffuse;
- limited prurigo with pronounced lichenization;
- atopic dermatitis;
- allergic and simple dermatitis;
- urticaria;
- exudative erythema multiforme;
- chronic simple lichen (neurodermatitis limited);
- dermatoses that are not amenable to treatment with other drugs (especially warty lichen planus);
- skin dyshidrosis ;
- flat red lichen.
Contraindications
In accordance with the instructions for use with Belosalik lotion, the following are contraindications:
- excessive sensitivity;
- fungal, viral and bacterial skin diseases (syphilis, pyoderma, skin tuberculosis, chicken pox, actinomycosis, herpes, sporotrichosis and blastomycosis);
- rosacea;
- post-vaccination skin reactions;
- perioral dermatitis;
- trophic ulcers in chronic venous insufficiency;
- pregnancy;
- skin tumors (cancer, atheroma, nevus, sarcoma, hemangioma, epithelium, xanthoma, melanoma);
- lactation period (can not be applied to the epidermal cover of the breast before feeding);
- children under one year old.
It should be used with caution in the treatment of children older than a year, liver failure, prolonged treatment, especially with occlusive dressings.
So it says in the instructions. We will consider the reviews for Belosalik lotion below.
Dosage Features
The lotion is applied externally to inflamed areas with a thin layer and gently rubbed (two to three times a day). You can do this with a cotton pad or fingers.
If necessary, occlusive dressings are applied to the affected area, changing every day. Due to the fact that breathing of the skin and evaporation of sweat are delayed, a moist chamber is formed, which contributes to loosening of the stratum corneum and deeper and faster penetration of the product - about a hundred times more than during normal application.
Lotion "Belosalik" is convenient to use on the epidermis of the scalp. With ease, the solution can be distributed on the skin surface, it does not cause hair sticking, it allows you to feel cool and leaves no noticeable marks.
A few drops of the drug for external use are distributed on the skin surface, gently rubbed twice a day. If the case is easy, then even a single application is enough.
The therapeutic course lasts up to three weeks. If long-term treatment is necessary, then the drug is used every other day. During the treatment of chronic pathologies, it is necessary to continue using the drug even after the symptoms disappear (in order to avoid relapse of the disease).
Side effects
The local influence of betamethasone can provoke collagen reduction, which manifests itself in the form of the following symptoms:
- stretch marks;
- atrophic skin changes;
- telangiectasia;
- ecchymoses;
- folliculitis;
- contact allergic dermatitis;
- hypertrichosis.
Long-term treatment with lotion can cause:
- development of hypo- and hyperpigmentation of a local nature;
- suppression of the functioning of sweat glands;
- itching and rash on the skin;
- secondary skin infections (due to the inhibitory effect of betamethasone on the immune system).
This is confirmed by the instructions for use and reviews of the Belosalik lotion.
With topical application of salicylic acid, dermatitis can develop.
Side effects of a systemic nature occur due to prolonged use or an overdose of a drug.
With too strong absorption of the active substance into the bloodstream, the functioning of the adrenal cortex is inhibited, which is manifested by intracranial hypertension (in the treatment of children), Cushing's syndrome, glucosuria, hyperglycemia. Suppression of adrenal gland activity in childhood is also accompanied by a slowdown in growth, a decrease in the content of cortisol in urine and blood, and weight gain.
With intracranial hypertension, headaches are observed, and the fontanel protrudes. In case of an overdose of salicylic acid, drowsiness, fatigue, pallor of the skin, vomiting, auditory impairment and nausea appear. In this situation, sodium bicarbonate is prescribed for stronger urine output and alkalinization of urine.
If the above symptoms are identified, you must stop using the product. The treatment includes restoring the normal balance of water and salts, as well as symptomatic therapy. In the case of the development of a toxic chronic effect, the drug should be gradually withdrawn.
Overdose
Signs: secondary adrenal insufficiency, Cushing's syndrome, hypercorticism. In this case, symptomatic therapy is carried out.
special instructions
Avoid contact with eyes if possible. It is forbidden to apply to the skin near the eyes and mucous membranes.
It is undesirable to use the drug for a long time on the skin of the face. Do not use in the anogenital area.
Children need to be treated with this tool for a short time, since there is a possibility of systemic absorption of active components in large quantities due to the predominance of the surface of the skin integument over weight and insufficient epidermal maturity.
If allergic symptoms or local irritation appear, then therapy should be discontinued.
Interaction with other means
Features of interaction with other drugs are not indicated.
With simultaneous use with dermatological and cosmetic products to combat acne, drugs that contain ethanol, as well as medical soap that has a drying effect, skin irritation may appear in some cases.
Lotion analogues and reviews
Belosalik lotion has analogues. These include lotions "Diprosalik" and "Elokom-S."
"Belosalik" has proven itself in the fight against acne, acne, inflammation, a cold on the lips. The bottle is enough for a long time. With a tendency to skin rashes, he becomes a real helper.
Also, the drug has proven itself in psoriasis, it helps to temporarily relieve its manifestations, to mitigate itching. However, it should not be used for too long, since it has a hormonal nature.
Among the shortcomings are the high price. In addition, after the withdrawal of the remedy, the pathology may worsen. Some patients are confused by the pungent odor. When applied to inflamed skin, a burning sensation can be felt, in some cases, irritation appears.