For the treatment of schizophrenic and bipolar disorder , drugs based on the substance of olanzapine are used. There are many drugs with different brand names, but the same antipsychotic effect. One of these drugs is the medication "Olanzapine", its analogues in their composition contain a common active component.
Description of the drug
This antipsychotic drug is produced by ALSI Pharma ZAO in the form of light yellow tablets, the shape of which resembles a biconvex cylinder.
There is a medicine in four dosages. Tablets of each dose are distinguished by the engraving inscription. For a dosage of 0.0025 g, the inscription "L" is provided, for a dose of 0.005 g, the designation "FA20" is used. Tablets with 0.0075 g of olanzapine are engraved with "F20C", and with 0.01 g of the active ingredient contain "N30C".
The structure of the drug is formed by inactive ingredients, which include microcrystalline cellulose, monohydrate lactose, crospovidone filler, magnesium stearate. Their number increases two, three and four times depending on the dosage of olanzapine.
Tablets of all doses are packaged in 7 pieces in blisters, which in a pack can be 4 or 8 pieces.
Means "Olanzapine" instructions for use relates to antipsychotic antipsychotic drugs that exhibit an affinity for serotonin, dopamine, muscarinic, adrenergic and histamine receptor formation.
Excitatory activity of a mesolimbic dopaminergic neuron is selectively reduced, and insignificant activity on striatal nerve conduction, which regulates motor functioning, appears. The strength in the conditioned protective reflex decreases if a low dosage is used that does not cause cataleptic sleep.
The medicine "Olanzapine" increases the anti-anxiety effectiveness in the anxiolytic test task when it is performed. Carries out the removal of negative and productive symptoms in the form of delusions and hallucinogenic visions.
Why use
With Olanzapine tablets, the effect is on schizophrenic conditions in adulthood in the acute stage, as a holding and long-term anti-repetitive treatment. They are used in a psychotic disorder with fruitful signs in the form of delusional ideas, hallucinogenic visions and with negative symptoms such as emotional flattening, a decrease in socially significant actions, and impoverishment of the speech apparatus.
The medicine eliminates the recurrence of seizures with bipolar disorder, if the tablets successfully treat the manic stages.
The drug "Olanzapine" is prescribed for adults with bipolar affect disorders in the form of monotherapy or in conjunction with medicines containing lithium ions or valproic acid. The medicine is used to relieve the acute form of manic or mixed action, which can manifest itself with psychotic symptoms, as well as have a rapid change in stages.
The drug is combined with fluoxetine medications under depressive conditions that are associated with bipolar disorders.
Terms of use
The medicine "Olanzapine", the instructions for use recommend taking orally from 0.005 to 0.02 g per day, without adhering to the diet.
Schizophrenic condition adult patients are treated with an initial daily dosage of 0.010 g.
Acute adult mania, characterized by bipolar disorder, is removed with a daily amount of olanzapine in 0.015 g, which is administered once. If tablets are used for retention effects in conjunction with drugs based on lithium ions or valproic acids, then a daily dose of 0.010 g at a time is prescribed.
Depressive processes in adulthood caused by bipolar disorder are removed with a daily amount of 0.005 g, which is combined with 0.020 g of fluoxetine substance. If necessary, it is allowed to adjust the dosage of medicines.
For the elderly, patients with a possible threat of severe kidney or liver failure in the chronic form, when there are risks associated with the female sex, senile age characteristics, when the metabolism of olanzapine is slowed down, its initial daily amount is reduced to 0.005 g.
Similar means
The drug "Olanzapine" has analogues with different trade names. They are produced both by domestic and foreign manufacturers.
Among Russian manufacturers, the Technology of Drugs LLC company with the Olanzapin-TL preparation, in a tablet form of 0.0025 g with a film coating, is distinguished.
Another domestic medicine is Olanzapin, manufactured by Severnaya Zvezda CJSC. It exists in tablet form with a film coating and a dose of 0.005 g.
The Russian factory Canonfarm Production CJSC produces the drug Canon Olanzapine.
The Israeli medicine is Olanzapine-Teva Medication manufactured by Teva Pharmaceutical Enterprises Ltd.
The Slovenian counterpart is Zalasta Ku Tab, in tablets of 0.015 g intended for resorption. Produced by the Krka Novo mesto enterprise. Also, this plant produces the drug "Zalasta" in tablets.
The Swiss counterpart is Ziprex drug in the form of a lyophilisate in vials, from which a solution for intramuscular injection is prepared, with a dose of 0.010 g. In the form of 0.005 g dispersible tablets, there is Ziprex Zidis. They are manufactured by Eli Lilly Vostok S.A. On the pharmaceutical market there is a powder medicine “Ziprex Adera” with a dosage of 0.21 g.
The Polish company AO "Polfarma" produces the medicine "Normiton" in tablets with a shell coating of 0.005 g.
The drug "Olanzapine" Hungarian analogues are manufactured by the company "Gedeon Richter" under the name of the tablet "Parnasan", and the pharmaceutical plant "EGIS" developed the drug "Egolanza".
Description of the drug "Zalasta"
This antipsychotic agent refers to antipsychotics. Light yellow tablets have a round, slightly biconvex shape with dark spots. There are six dosages: 0.0025 g, 0.005 g, 0.01 g, 0.015 g and 0.02 g of olanzapine. Cellulose, starch in pre-gelatinized form and corn, dehydrated aerosil ingredient, magnesium stearate are considered additional inactive components.
For marking the tablet form of “Zalasta”, the instructions for use describe the designations in the form of engravings indicating the dosage. Consumer packaging are contour plates with 7 tablets. A pack may contain 4 or 8 of these blisters.
This antipsychotic drug exhibits broad pharmacological activity. Antipsychotic effects are associated with blocking the receptor formations of the dopamine type. Sedative activity is caused by inhibition of the adrenergic receptor sites that form the reticular formation in the cells of the brain stem.
Antiemetic activity is possible when the D 2 -dopamine receptor site is stopped in the trigger type zone, which is located in the vomiting center.
The hypothermic role is carried out when the receptor formations of the dopamine type are blocked in the hypothalamus.
The medicine "Zalasta" instructions for use are recommended for use in schizophrenic manifestations. Tablets are able to actively maintain changes in clinical symptoms during prolonged treatment of patients with an initial positive effect on the medication.
The tool eliminates episodic mania in a medium or complex form. Pills carry out preventive manipulations of the recurrence of insanity in bipolar disorders in people with manic episodes.
The medicine is intended for oral one-time daily administration. Food particles do not affect the absorption of olanzapine, which allows the use of tablets at any time. If you refuse the medication, you should gradually reduce the dose.
For the treatment of schizophrenic disorders, an initial dosage of 0.010 g per day is used.
The episodes of mania begin to be treated with a daily dose of 0.015 g, which is administered in one application or 0.010 g when combined with other antipsychotics.
Prevention of repeats of bipolar disorder in the weakening stage is carried out by primary dosing of the drug at 0.010 g per day. If people take this drug to eliminate episodic manic syndrome, then the same doses are used for retention therapy. You should increase the amount of medication when new grouped or depressive episodic manifestations occur, and also add treatment for mood disorders.
The daily dose of the drug to eliminate schizophrenic disorders, manic seizures and prevent repetition of bipolar disorders use from 0.005 to 0.020 g, the value of which depends on the clinical parameters of the patient.
Older people are not advised to reduce the initial dosage to 0.005 g, but such actions are used for patients from 65 years of age, if there are risk factors.
Description of the drug "Olanzapine Canon"
This antipsychotic medication of antipsychotic action is available in tablet form with a shell coating. The tablets are rounded in shape with two convex yellow surfaces, the inner contents of the same color.
There are two dosages: 0.005 g and 0.01 g olanzapine. Auxiliary ingredients include low substitution hydroxypropyl cellulose, calcium hydrogen phosphate, croscarmellose sodium, mannitol, magnesium stearate.
The shell film is formed by a yellow opadra of the second type, polyvinyl alcohol, macrogol, talc, titanium dioxide, iron oxide.
Treatment with the drug is prescribed for worsening, for retention and long-term anti-relapse use in adult patients suffering from schizophrenic disorders.
The medicine carries out monotherapy, as well as combined combination with lithium-containing compounds with a strong form of manic or mixed attacks of bipolar affect disorder, which happen with psychotic expressions and with an early change of stages. The drug prevents repetitions in people with bipolar disorders, if the drug helped to cope with the manic stage.
In the treatment of adults with depression caused by bipolar disorder, as well as in a stable depressive degree, the drug "Canon Olanzapine", an antipsychotic, can be combined with fluoxetine-containing agents.
It is taken orally, not adhering to a diet. The instruction recommends taking into account the therapeutic dosage of the medication, which is 0.005-0.020 g per day. The amount of this drug is selected for each patient separately, depending on the clinical signs.
Schizophrenic disorders of an adult patient they are treated with an initial daily dosage of 0.010 g, which is taken at a time.
The state of acute mania of bipolar disorder is eliminated with a daily dosage of 0.015 g or 0.010 g of olanzapine combined with products containing lithium ions or valproic acid.
Supportive use during bipolar disorder is carried out with an initial daily dosage of 0.010 g. If patients have taken the medication in an acute manic state, then continue to use the drug in the same amounts.
Depressive disorders associated with bipolar disorder in adult patients are treated with a combination of 0.005 g of olanzapine and 0.020 g of fluoxetine drugs, which are administered in the evening.
The antidepressant effect is manifested by the drug in an amount of from 0.006 to 0.012 g with an average daily dosage of 0.0074 g. The dose of fluoxetine medications ranges from 0.025 to 0.030 g. If necessary, the dosage of both drugs can be reviewed.
Therapeutic stable form of depression is removed by a combination of 0.005 g of olanzapine and 0.02 g of fluoxetine agents, which are administered once in the evening.
Description of the drug "Ziprex"
This antipsychotic is produced in tablet form with a shell coating. There are four dosages of the drug: 0.0025, 0.005, 0.0075 and 0.010 g, which have the corresponding designations on the surface "LILLY 4112", "LILLY 4115", "LILLY 4116", "LILLY 4117".
Inactive components in the form of milk sugar, hydroxypropyl cellulose, crospovidone, microcrystalline cellulose, magnesium stearate formed the structure of the drug.
Tablets are packaged in blisters of 7 pieces, each pack contains 4 contour packs.
There is also a lyophilized form intended for the manufacture of intramuscular solutions. A yellow liquid with a dosage of 0.01 g is packaged in bottles. Inactive components are considered lactose monohydrate and tartaric acid.
The medicine exhibits an antipsychotic effect.
The active ingredient of the drug behaves like a ligand that binds to serotonin, dopamine, m-choline, H1-histamine and alpha1-adrenergic receptor formations. Olanzapine has a selective effect on the state of the limbic system.
The preparation "Ziprexa" recommends the use of the drug for severe stages of schizophrenic and psychotic disorders, which are accompanied by obvious signs in the form of delirium, hallucinations, mental disorders, hostile, suspicious mood or negative type in the form of emotional and social exclusion, disorders of the speech apparatus. The medicine is prescribed to eliminate secondary affective symptoms caused by schizophrenic disorders.
The Ziprex tablet is recommended for drinking orally, at any time. At the beginning of treatment, a single dosage is 0.010 g. Subsequently, the daily dosage ranges from 0.005 to 0.020 g, which is associated with a symptomatic picture.
A medication is administered intramuscularly if it is urgent to stop the excitation of a psychomotor nature in people with schizophrenic, bipolar affect disorders and dementia.
Before use, the lyophilisate is diluted in 2.1 ml of an injectable aqueous medium. It turns out a solution transparent with a yellow tint.
Nervous emotional arousal of schizophrenic and bipolar disorder is removed with a single dosage in 0.010 g.
Given the therapeutic picture of the patient, a repeated administration of a dosage of 0.010 g is carried out after 120 minutes from the first application, and the next 0.010 g is used after 240 minutes from the second application.
For further treatment with Ziprex, they switch to its tablet form with a dosage of 0.005 to 0.020 g.
Agitation in case of dementia is removed with a dose of a single intramuscular dose of 0.0025 g. Given the clinical picture of the patient, the second dose of 0.005 g is administered after 120 minutes from the first application.
Description of the drug "Adera Ziprex"
There are medicines "Olanzapine" analogues, which are available in the form of a powder of 0.405 g olanzapine in bottles with a solvent, syringe and needle.
Means "Adera Ziprex" refers to antipsychotic drugs of antipsychotic activity.
The medicine stops worsening, is used for the holding and long-term anti-repetitive treatment of schizophrenic and mental changes with symptoms highly productive in the form of delusional ideas, hallucinogenic visions and negative ones with emotional flattening, impoverishment of the speech apparatus.
The drug treats strong manic and combined bipolar disorder attacks, during which a psychotic manifestation and an early change in stages are possible.
The initial daily dosage is used at 0.010 or 0.015 g. The daily amount of the drug is selected for each patient separately, taking into account the clinical picture. Usually a therapeutic daily dose of from 0.005 to 0.020 g is used.
An increase in dosage is possible only if the results of the tests are available. An increase in the amount of the drug is carried out in stages, every day.
In elderly patients, in the presence of insufficient kidney and liver function, the initial daily dose is prescribed at 0.005 g.
Cost of analogues
A wide range of antipsychotic drugs allows you to choose the right drug, which is suitable for quality and cost. Medicines "Olanzapine" the price is relatively small. A pack of tablets can be bought for 290 rubles.
The medication "Zalast" price is from 1370 rubles.
Ziprex Zidis tablets are considered an expensive remedy.For the packaging of the drug you need to give 2370 rubles. The cost of the analogue “Ku-tab Zalasta” is 1075 rubles.
On the medicine "Ziprex" the price of the reviews gets negative. A pack with 28 tablets costs 4760 rubles.
The drug “Olanzapine” will be available for vulnerable groups of the population, the price of which is several times lower.
Patient opinions
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The human body is individual, therefore tablets act differently on each patient. To find the right product, you need to consult a doctor.