What is part of Nurofen? What is this popular product made of? There are several options for the release of the drug on sale - special for children and intended for adults, tablet and liquid. Each of the options has its own compositional features. “Nurofen” contains ibuprofen - this component explains its pharmacological activity, but other substances have been used by the manufacturer.
general information
The composition of Nurofen can be found if you familiarize yourself with the instructions that the manufacturer attaches to the drug. For each form of release, the accompanying documentation is compiled individually, since different substances are used for production. It is especially important for people suffering from allergic reactions or hypersensitivity to any substances used in the pharmaceutical industry to familiarize themselves with the detailed list of ingredients.
Far from always, the patient himself can determine whether there are compounds dangerous for him personally in the Nurofen. In order to avoid a negative response of the body, it is necessary to inform the doctor about all possible individual reactions. The doctor, knowing what an allergy is possible with the client, will be able to assess the extent to which the described drug is suitable for him, what dangers are associated with his use. You need to be especially careful when choosing a drug for a small child. However, the manufacturers of the medication in question are well aware of how difficult it is to create a safe product for children, therefore, the Nurofen children’s composition contains only safe and effective substances.
What is inside?
The composition of Nurofen (200 mg) of the most, perhaps, the most popular form of release contains 200 mg of the active compound and additional substances. The main component is ibuprofen. It is he who provided the effectiveness of the tool. One package contains 6-24 tablets.
Nurofen tablets also contain carmellose, talc, sucrose, sodium citrate and lauryl sulfate, macrogol and a coloring component. The manufacturer used stearic acid, titanium dioxide, compounds extracted from acacia, and silicon dioxide.
The enhanced format of the issue is Nurofen Forte. The composition of the tablet also begins with ibuprofen - here it is twice as much as in the embodiment described above, that is, 400 mg. One package contains 12 capsules. In addition to ibuprofen, the manufacturer used coloring components, carmellose and macrogol, sodium and silicon, titanium compounds, talc and acacia extract. Sucrose is present in the tablets.
There are several options for the release of Nurofen suspension on sale. The composition also begins with ibuprofen - 100 mg of the active ingredient per 5 ml. The manufacturer also used maltitol, aromatic additives, water and glycerin, gum, sodium chloride, citrate, saccharin in the manufacturing process. The Nurofen suspension contains polysorbate, citric acid and domifen bromide.
What other options?
In the instructions for use, the composition of "Nurofen" in the form of suppositories for rectal administration begins with ibuprofen - this substance is contained in an amount of 60 mg in one suppository. The drug is packaged in cardboard boxes containing blisters with a dozen candles. The manufacturer must invest in the boxing accompanying documentation. From it you can find out what additional substance was used in the manufacture of suppositories. This is solid fat.
You can buy a composition of "Nurofen Forte" for children. This is an enhanced release of the drug containing 200 mg of active compound per 5 ml of suspension. The medication is intended for oral use. In addition to the main substance, the composition of the drug “Nurofen Forte” for children includes maltitol, water and glycerin. The manufacturer used aromatic additives and saccharin, gum and citric acid. Nurofen contains polysorbate, sodium derivatives and domiphene.
Nurofen Plus and Nurofen Express
The composition of the capsule begins with ibuprofen. The active substance is added in the form of a lysinate in an amount of 342 mg, which is similar to 200 mg of pure ibuprofen. As additional compounds, povidone, starch, magnesium stearate, mellose, coloring additives, ink, talc were used. The composition of Nurofen Express and a description of the appearance of the drug can be seen in the instructions enclosed by the manufacturer in each package. It is indicated here that the product is in the form of capsules of white or close to white color. The structure should be homogeneous, and the surface of each instance polished. The tablets are covered with a thin film, letter N is printed on one side. If you cut the capsule across, you can see the white mass inside. Color deviation is allowed, but the color should be close to white.
The composition of Nurofen Plus is more complex. This drug belongs to the number of combined, at the same time ibuprofen, codeine are present in it. For 200 mg of ibuprofen in one tablet - 10 mg of codeine. This combination provides a pronounced analgesic effect, so "Nurofen Plus" is the most powerful composition possible. It is dispensed from pharmacies strictly in the presence of a doctor’s prescription with seals and signatures. Nurofen Plus tablets contain sodium glycolate, starch, cellulose and mellose, talc and opaspray. Additional components simplify the medication and provide it with a shelf life.
Pharmacology
How and why does Nurofen work? The manufacturer explains this in the instructions - accompanying documentation is present in each pack. Particular attention is paid to the main substance - ibuprofen, which comes first in the composition of Nurofen. The instruction explains that this is a non-steroidal anti-inflammatory drug obtained during the processing of propionic acid. The effectiveness of the compound for pain, fever, activity of foci of inflammation has been proven. A non-hormonal drug inhibits the production of prostaglandins, neurotransmitters responsible for the inflammatory process, pain.
Studies have shown that ibuprofen inhibits platelet aggregation. The process is reversible. If acetylsalicylic acid and Nurofen are used, the effect of the first substance on platelet aggregation can be reduced if the acid enters the human body in small quantities. The information is pretty limited. According to experts, the composition of Nurofen (adult and for children) is such that unsystematic use of this drug does not allow to obtain a clinically significant effect.
Kinetics
When using the “Nurofen” composition for adults, the tablet resolves. The processes are localized in the gastrointestinal tract. In a short time, the active component comes into contact with plasma proteins. The maximum concentration in the plasma component of the blood is achievable three quarters of an hour after receiving a dose of the drug, if the substance is used on an empty stomach. When using the drug during the meal, the maximum concentration is achievable on average an hour or two after ingestion.
As indicated in the instructions for use for tablets, suppositories, syrup for children "Nurofen", the composition works primarily due to ibuprofen, the metabolism of which occurs in the liver. Elimination is carried out by the kidneys, a certain percentage - invariably, etc. - in the form of reaction products. The half-life reaches a couple of hours. It was not possible to establish significant differences in the profile of the pharmacological kinetics of the drug during its use by children, adults and elderly patients.
When will it help?
It is recommended to use "Nurofen" if the head or teeth are sore, and the abdominal pain associated with the menstrual cycle suffers. The drug helps to relieve migraines and neuralgia. "Nurofen" is effective for joint, muscle, rheumatic pain. You can use the remedy if you are concerned about the manifestations of flu, colds.
The remedy is intended to relieve symptoms, but does not eliminate the root cause of the problem - this is due to the composition of Nurofen. Paracetamol, acetylsalicylic acid and other non-hormonal anti-inflammatory drugs are not used in combination with the drug in question - the drugs do not enhance each other's effect.
Nurofen, like other NSAIDs, is intended for short-term use. The drug is designed for oral use. The tablets are washed abundantly. No need to chew or disrupt the integrity of the shell.
Features of use
The manufacturer recommends using Nurofen in a minimum dosage, showing the desired result. The tool can be used only for a short time. If symptoms persist for five days or a longer period of time, if the patient worsens, it is necessary to suspend the use of a non-steroid medication and seek the help of a doctor to select a more optimal treatment strategy.
For adults and children whose weight exceeds 20 kg, Nurofen is shown in an amount of 20-30 mg / kg. The volumes obtained in such calculations are intended for consumption within one day. You can not take the drug in an amount greater than 30 mg / kg.
For children whose mass varies between 20-30 kg, you can use one Nurofen tablet containing 200 mg of the active compound at a time. If there is a need for a repeat, you can take the drug again 6 hours after the first dose. No more than three tablets are used per day. The maximum permitted volumes of ibuprofen are 600 mg.
For children, whose body weight is more than 30 kg, and for adults, “Nurofen” is shown in the amount of 1-2 tablets, which in terms of ibuprofen is 200-400 mg. The drug is used at intervals of 4-6 hours. The need to use the next dose is evaluated based on the severity of the patient's condition. The drug must be washed down with clean water without additives. It is unacceptable to use more than six tablets per day, which is equivalent to 1.2 g of ibuprofen. For patients in advanced age, the regimen is similar to other groups of patients. There is no need for individual dose selection.
Nurofen Forte: Nuances
This release option is also intended for short-term use - the tool is used to alleviate the condition. "Nurofen Forte" is not a drug for the treatment of the root cause. It can be used at the age of 12 years and older. Dosage regimen - up to 1.2 g per day, between doses - breaks of at least four hours. Single dose - 1 tablet. Do not use more than three capsules per day. Nurofen Forte must be washed down with water.
The drug is recommended to be used in the lowest effective dose. The duration of use is reduced, as far as the condition of the patient allows. If there is a need to use an anesthetic for ten days in a row and for a longer period, you must consult a doctor. If the pain does not go away while taking Nurofen Forte or the condition worsens, it is important to immediately take the help of a specialist.
For people of different age groups, the dosage rules are the same. There are no special conditions for patients in old age. In case of impaired renal functionality of a small and medium degree, the drug is used in standard mode.
Nurofen for children
For kids, the drug is designed as a suspension. This format can also be used, only for a short time. The drug is taken orally. The dosage is determined by assessing the age, weight of the baby. A single dose varies between 5-10 mg / kg. More than 30 mg / kg of ibuprofen should not be consumed per day.
- If the patient is more than three months old, but less than six months old, and weighs less than 5 kg, Nurofen suspension is taken at eight-hour intervals of 2.5 ml. A day, you can use no more than three servings, not more than 150 mg.
- For children aged from six months to a year, Nurofen is allowed in the same single doses, but up to four times a day. Between receptions maintain six-hour intervals. 200 mg of ibuprofen is allowed per day.
- For the 1-3 year age group with eight-hour intervals, Nurofen is put in an amount of 5 ml. The drug is used no more than three times a day, the maximum volume for 24 hours is 300 mg.
- For the age of 4-6 years, it is allowed to use 7.5 ml with eight-hour pauses three times a day. Dosage for 24 hours - 450 mg.
- From seven to nine years old, Nurofen is allowed in the amount of 12 ml three times a day, which is equivalent to 600 mg.
- For the age group of 10-12 years, the suspension is used in an amount of 15 ml three times a day, in total - 900 mg.
Some nuances
If the vaccine provoked a fever, for children from three months to six months of age, "Nurofen" in the form of a suspension is shown once in a dose of 2.5 ml, after six hours, the reception can be repeated. No more than 100 mg are used per day. The duration of the therapeutic course in the predominant percentage of cases is three days, but individual deviations up and down are possible. If after three days the fever continues to disturb, it is necessary to show the child to the doctor. If the symptoms of the disease when using the Nurofen suspension in children 3-6 months of age remain 24 hours or longer, an urgent need to see a pediatrician.
Suspension "Nurofen Forte"
The drug is reassigned for oral use. A day should take medicine in an amount of 20-30 mg per kilogram of patient weight. The resulting volumes are divided into several portions, between the reception of which it is necessary to maintain breaks of 6-8 hours. Nurofen Forte is designed for short-term use. Immediately before use, the substance in the vial is thoroughly shaken.
For children over six months of age, the suspension is used in an amount of 1.25 ml up to 4 times a day, at the age of three years - 2.5 ml three times a day. For children older, the drug is also shown in a three-time use format. The following restrictions are taken into account: for babies under six years old - 3.75 ml, under the age of 9 years old - 5 ml, up to 12 years old - 7.5 ml.
If the symptoms do not exhaust itself in three days of using Nurofen Forte, it is necessary to show the patient to a doctor. This requires a deterioration, increased pain. With increased sensitivity of the stomach, the drug is used strictly during a meal. If the failure of the liver and kidneys is found in mild or moderate severity, dosage adjustment is not necessary.
Candles "Nurofen"
In this form, an analgesic, antipyretic medicine is used rectally. One suppository contains 60 mg of the active compound. The drug can be used for children over three months of age. Dosage is determined based on body weight, age of the patient. Do not use more than 10 mg / kg at a time. Candles are set at six-hour intervals between treatments. The maximum dosage per day is 20-30 mg / kg. It is necessary to divide these volumes into 3-4 introductions.
With a weight of up to 8 kg, one candle is placed up to three times daily with intervals of 6-8 hours between treatments. With a weight of up to 12.5 kg, a candle is placed every six hours (up to four times a day). The duration of the course of therapy is usually three days. If during this time the symptoms do not go away or the condition becomes worse, it is necessary to show the patient to a doctor.
Suppositories are recommended only when "Nurofen" cannot be used orally. This is possible with severe vomiting and some other specific conditions.
It is impossible!
- It is unacceptable to use "Nurofen" in any of the formats of release, if the patient has an increased sensitivity to the active ingredient or excipients used by the manufacturer in the manufacture of the product.
- It is unacceptable to use Nurofen if previously ibuprofen and other non-hormonal anti-inflammatory drugs, including acetylsalicylic acid, provoked an increased sensitivity reaction. This is possible in the form of angioedema, urticaria and other conditions.
- "Nurofen" is contraindicated for persons suffering from ulcerative processes in the stomach, intestinal tract, as well as bleeding localized here. This applies to the active form or past relapses, when there are two or more episodes.
- If previously non-hormonal anti-inflammatory provoked gastrointestinal perforation, bleeding in this area, "Nurofen" can not be used.
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