The instruction attached to the drug "Preductal" indicates that it refers to agents that improve the metabolism of neurosensory organs and myocardium during ischemia. The main active ingredient of the drug is trimetazidine. This drug is available in the form of biconvex round tablets coated with a red film coating. They are characterized by a modified release of trimetazidine. Two blisters of the drug "Preductal" are placed in a cardboard pack, instructions for use are also attached.
This drug prevents the intracellular decrease in ATP, optimizing the energy metabolism of cells in a state of ischemia and hypoxia. That is, the main effect of the drug "Preductal" is to ensure the normal functioning of ion membrane channels and transmembrane transfer of sodium and potassium ions. At the same time, cell homeostasis also persists.
The instruction supplied with the drug "Preductal" describes in detail its mode of action. From the package insert, you can find out that trimetazidine, which is part of the drug, reduces the rate of oxidation of fatty acids, which in turn leads to increased glucose oxidation. As a result, the conjugation between oxidative decarboxylation and glycolysis is restored, and this protects the myocardium from ischemia.
Developing the drug "Preductal", the manufacturer conducted many experiments. During them, the following properties of the main active substance were established:
- minimizes the size of intracellular acidosis;
- does not directly affect hemodynamic parameters;
- reduces the degree of myocardial damage.
In addition, trimetazidine in people with angina pectoris prevents sudden changes in pressure, improves left ventricular contractions, and minimizes angina attacks. After 15 days of taking the drug "Preductal" in patients, the coronary reserve increases, which helps to slow down the development of ischemia, which is caused by physical exertion.
There are several different drugs with the main substance trimetazidine. One of the most common is the drug, which in one tablet contains 35 mg of the active substance - Preductal MV. Instructions for its use indicate that this drug is recommended for long-term treatment of coronary heart disease, as well as for the treatment of chorioretinal and cochlear-vestibular disorders of ischemic origin.
When developing the drug, many experimental studies were carried out, including scientists trying to find out whether it is possible to take this medicine for women who are breast-feeding, or pregnant. However, at present clinical data are still insufficient. Therefore, it is not recommended to prescribe the drug to pregnant women. Breastfeeding is also better to stop during the treatment period.
It is worth saying that there are some other contraindications to the use of the drug "Preductal". Instructions for use lists the following:
- renal failure, which has a pronounced character;
- individual increased sensitivity to the components of the drug;
- this product is not recommended for persons under 18 years of age;
- caution should be taken when taking the drug in patients with liver failure.
Like any other medicine, the drug "Preductal" should be taken in strictly defined dosages. Otherwise, patients may experience some undesirable effects of the drug: nausea, abdominal pain, vomiting, dyspepsia, diarrhea, asthenia. Hives, skin itching, headache, or dizziness are possible. If these or other effects are detected, it is recommended that you stop taking the medicine to consult a doctor.