Midokalm tablets are coated with a white film membrane, have a round biconvex shape, and have a weak specific smell. On one side there is an engraving “50” or “150”, two layers are visible on a cross section.
The composition of one tablet "Midokalm" includes tolperisone hydrochloride as an active ingredient. Auxiliary components: lactose monohydrate, anhydrous colloidal silicon, talc, citric acid monohydrate, microcrystalline cellulose, stearin, corn starch, hydroxypropyl methyl cellulose 2910, macrogol 6000, titanium dioxide.
Tablets "Midokalm" belong to the clinical and pharmacological group of central muscle relaxants.
The mechanism of action of the drug remains unclear to the end. Midokalm tablets have a local anesthetic, membrane stabilizing effect. The medication is able to inhibit the conduction of impulses of neurons of motor and afferent primary fibers. This provokes the blocking of polysynaptic and monosynaptic reflexes in the spinal cord.
The ability of the drug to secondary inhibition of the release of mediators is likely. In addition, the drug eliminates the facilitated holding of excitation in the reticulospinal path. The use of Midokalm enhances peripheral blood flow, regardless of the effects of the central nervous system. With the development of this effect, weak adrenergic blocking, as well as the antispasmodic effect of tolperisone is of importance.
Good absorption from the gastrointestinal tract after oral administration is noted. The active component is metabolized in the kidneys and liver, excretion occurs in the form of metabolites by the kidneys.
Midokalm tablets. Instruction Indications.
The medication is prescribed for degenerative and organic diseases of a neurological nature, accompanied by an increase in tone in striated muscles (multiple sclerosis, encephalomyelitis, muscle contractures, injuries in the pyramidal pathways, muscle rigidity, the consequences of stroke - acute disorders of blood circulation in the brain, back). The drug is also indicated as a treatment in the recovery period after traumatological and orthopedic interventions, with obliterating vascular pathologies as part of complex therapy, cerebral palsy. In addition, the medication is prescribed for muscle cramps, encephalopathy with muscular dystonia, and hypertension.
Midokalm tablets. Instructions for use.
The dosage is determined depending on the symptoms and tolerance of the drug individually.
For patients from one to six years old, the dose of the drug is calculated in accordance with the body weight (five milligrams per kilogram). Three doses are prescribed throughout the day.
Patients from seven years to fourteen daily dosage of two to four milligrams per kilogram of body weight. Three meals a day are recommended.
Side effects may include vomiting, nausea, discomfort in the abdominal region, anaphylactic shock, itching, dyspnea, maculopapular rashes, erythema.
Contraindications to the appointment and reception of tablets "Midokalm" are:
- age up to a year;
- myasthenia gravis;
- hypersensitivity (intolerance) to the drug.
The use of the drug during pregnancy and breastfeeding is allowed in cases where the potential risk to the baby is lower than the expected benefit to the mother.
For children, "Midokalm" in a tablet form of 50 milligrams is recommended.
The use of the drug does not affect the ability to control mechanisms and drive vehicles, to concentrate and show the speed of the psychomotor reaction.
There is no evidence of an overdose of the drug.