Migraine is called a neurological disease, which is characterized by regular or episodic painful and severe attacks of pain, which is observed in one half of the head. This condition of the patient is not associated with serious injuries, stroke or brain tumor. The pulsating nature and intensity of pain is explained by the presence of vascular pathologies, and not by the patient's excessive stress.
It should also be noted that headaches with migraine are not associated with a sharp decrease or increase in blood pressure, an attack of ICP, or glaucoma.
To treat this condition, many experts recommend the use of the drug "Cofetamine." Instructions for use, a photo of the drug, reviews about it, similar tools and properties are presented below.
The composition of the medication, its release form and packaging
What form does Cofetamine take? Instructions for use, reviews indicate that this tool goes on sale in the form of tablets. They include ingredients such as ergotamine tartrate, potato starch, stearic acid, talc, caffeine, glucose and sugar.
The drug goes on sale in blister packs.
Pharmacodynamic features of the drug
What makes Cofetamine tablets so special? Instructions for use indicate that this is a combined remedy, the effect of which is due to the properties of the ingredients included in the composition.
Caffeine stimulates the vasomotor and respiratory centers, and also enhances the excitation of the cerebral cortex. In addition, this substance has a cardiotonic effect. It slightly increases blood pressure, and also increases the frequency of respiration and heart rate. Caffeine also reduces drowsiness, stimulates motor activity, eliminates the feeling of fatigue, and improves overall performance.
The severity and duration of action of this component depends on the state of the person, the type of nervous system and activity of the whole organism.
In small doses, caffeine has a stimulating effect, and in large doses it has a depressing effect on the central nervous system.
As for ergotamine, it has a vasoconstrictor effect.
Kinetic features
Where is the absorption of a drug like Cofetamine? Instructions for use indicate that this drug is quite well and very quickly absorbed from the intestine. Ergotamine is 98% bound to plasma proteins, and caffeine - 35%.
The highest concentration of this drug in the blood is observed 2 hours after taking the pill. Most caffeine is oxidized and demethylated, and then excreted along with urine.
Ergotamine metabolism is carried out in the liver with the formation of active derivatives.
This drug is excreted mainly with bile for five hours.
Indications for taking tablets
Are you aware of the purpose for which Cofetamine can be prescribed? Instruction, reviews report that such a medicine is very effective in the case of vasoparalytic form of migraine, arterial hypotension, as well as vascular, infectious and traumatic lesions of the central nervous system, used to reduce intracranial pressure.
Drug bans
When should you not prescribe the drug "Cofetamine"? The instruction (drug analogs are listed below) reports that this drug should not be taken with high sensitivity to the drug, as well as during the period of gestation and during lactation.
With caution, this medication is used for severe sleep disturbances, arterial hypertension, vascular and heart diseases (for example, angina pectoris, severe atherosclerosis, paroxysmal tachycardia, myocardial infarction, peripheral vascular disease), glaucoma, anxiety and panic disorders, kidney or liver diseases, agoraphobia and in old age.
The drug "Cofetamine": instructions for use
Analogs of this medicine should be prescribed only by a doctor. This is due to the fact that they can have completely different forms of release and methods of application.
This medication should be used during severe headache attacks. In this case, it is prescribed in the amount of 1-2 tablets twice a day. After that, for several days, the medicine is taken 1 tablet with the same multiplicity.
It is strictly forbidden to exceed the maximum single dose of the drug, equal to 2 tablets, and a daily dose of 4.
It should also be noted that you should not take the medicine in question for a long time. After a week of taking the drug, you need to take a break for 4 days.
Side effects
What are the possible side effects you should know before taking Cofetamine tablets? The instruction for this drug reports that it can cause the following reactions:
- cardialgia, dizziness, hypertension, agitation;
- tachycardia, headache, anxiety, skin itching, anxiety, tremors, increased reflexes, nausea, insomnia;
- diarrhea, convulsions, vomiting, paresthesia in the extremities, edema.
With prolonged use of the drug, myalgia, a general violation of sensitivity in the lower extremities and weakness are possible.
Overdose and drug interactions
What are the signs of an overdose when taking high doses of a drug like Cofetamine? The instruction for use states that in this case the patient manifests: drowsiness, nausea, lethargy, vomiting, numbness of the fingers of the upper and lower extremities, stupor, as well as epileptic seizures and coma. To eliminate such phenomena, gastric lavage is performed. Also, activated carbon is prescribed to the patient.
This medication enhances the effect of drugs, which include ergot alkaloids and caffeine. With its combination with barbiturates and anticonvulsants, the clearance of caffeine increases and its metabolism accelerates.
Nicotine promotes rapid excretion of the drug, and CNS stimulants - excessive excitability.
The medication in question reduces the effect of sleeping pills, narcotic analgesics, and also increases the toxicity and absorption of cardiac glycosides and non-narcotic analgesics.
The combined use of caffeine with beta-blockers often leads to mutual suppression of their therapeutic effects, and with adrenergic bronchodilators - to stimulate the central nervous system and other additive toxic reactions.
It should also be noted that the active substance of this drug can reduce the clearance of theophylline and other xanthines.
The vasoconstrictor effect of this medication is enhanced by beta-blockers, alpha-adrenostimulants, nicotine and serotonin agonists.
Ergotamine toxicity is increased by macrolides.
The cost of the drug and similar drugs
You can buy this tool in the amount of 10 tablets for 100-150 rubles. If required, it can be replaced with such similar drugs as Kofergoth, Ergofein, Nomigren, Ergoffin. However, you should always consult a doctor before doing this.
Reviews of specialists and patients
Now you have an idea of how the “Cofetamine” medication works. Instructions for use of this tool have also been described above. Reviews about it are mostly positive. Those people who use this remedy claim that it works effectively with severe migraines. Such a drug is more effective than other, more expensive drugs. Consumers report that they only need to take two tablets per day. This dosage immediately relieves pain. Although sometimes unpleasant sensations remain even after taking the medicine. But in this case they are not very pronounced.
The negative sides of this tool include a large number of adverse reactions that occur on the background of its intake.