To prevent the development of such a dangerous ailment as myocardial infarction, drugs based on acetylsalicylic acid are used in medical practice. The antiplatelet and anti-inflammatory effect is possessed by Lospirin. Instructions for use describe in detail the therapeutic effect, indications and rules for taking the medicine. Before you start treatment with the drug, you should familiarize yourself with the indications and contraindications regarding the use and be sure to consult a doctor.
Lospirin Composition
The main active ingredient in Lospirin tablets is acetylsalicylic acid, which is used as the main prevention of strokes and heart attacks.
One tablet contains 75 mg of active substance. Auxiliary components: silicon dioxide anhydrous colloidal, microcrystalline cellulose, stearic acid.
How does it work?
Acetylsalicylic acid refers to non-steroidal anti-inflammatory substances that have antipyretic, analgesic and antiplatelet effects. The main component is the ability to thin the blood, reduce its coagulability by inhibiting the synthesis of thromboxane A2 in platelet aggregations. This has a vasodilating effect (minor). The medicine "Lospirin" reduces the risk of developing myocardial infarction, cerebral stroke.
In the digestive tract, the drug is absorbed almost completely. The main process occurs in the small intestine. Thanks to the protective shell, it is possible to minimize the negative effect of acetylsalicylic acid on the gastric mucosa. The active component in the liver is biotransformed. In the body, substances quickly bind to blood proteins and are distributed throughout the system. The main route of excretion is the kidneys.
Indications for use
The drug is most often prescribed to patients for the prevention of myocardial infarction (primary and secondary) with angina pectoris. The following cases also apply to indications:
- Thrombosis prophylaxis.
- Prevention of blockage of blood vessels by emboli - particles that normally should not be in the blood serum.
- Prevention of cerebral stroke according to ischemic type.
- Mitral valve prolapse.
- Transient ischemic attack (reduces the risk of occurrence).
- Prevention of the formation of blood clots in deep veins.
- Prevention of heart attack in people at risk.
Causes of stroke and heart attack
A stroke is an ailment in which blood circulation in the vessels of the brain is disturbed, that is, oxygen and useful substances necessary for its normal functioning stop flowing there. A similar situation is with a heart attack, which most often affects the heart muscle (myocardium). The main reasons for the development of these pathologies are thrombosis and atherosclerosis. In the case of a stroke of the brain, there may be hemorrhage, which distinguishes the disease from a heart attack.
The main factors predisposing to the development of cardiovascular disorders include:
- Hypertension (high blood pressure).
- Diabetes.
- Overweight problems.
- Atherosclerosis of blood vessels.
- Improper nutrition.
- Regular use of alcohol, smoking.
- Hereditary predisposition.
"Lospirin" instruction for use recommends to be taken to prevent clogging of blood vessels by blood clots, blood thinning. Acetylsalicylic acid based tablets are considered quite effective.
Mode of application
The tablets are coated with a special coating that helps to “deliver” the active substance to its destination, that is, into the intestines, and thereby reduce the harmful effects on the stomach. Therefore, when taking the medicine, it is forbidden to chew it. Dosage will depend on the patient’s diagnosis.
A patient with suspected acute myocardial infarction should take Lospirin in a dosage of 75 to 300 mg per day to prevent death. The recommended course of treatment is 1 month. As a secondary prevention of heart attack and stroke, tablets are taken as directed by a specialist. The daily dose of Lospirin is 75-300 mg.
To prevent the formation of blood clots after surgery on the vessels, 75-150 mg of Lospirin are prescribed per day, or 300 mg every other day. The same amount of active substance is needed for patients at risk.
Features of the use of the drug "Lospirin"
Acetylsalicylic acid should not be prescribed to patients under the age of 16 years. This can lead to undesirable severe consequences, for example, Reye's syndrome. A pathological condition occurs in many children and adolescents who take drugs based on acetylsalicylic acid. The disease affects the functionality of the kidneys, causes brain edema and inflammatory processes in the liver. The syndrome can be determined by prolonged vomiting that occurs after taking the drug. This condition is extremely dangerous for the child's body and requires immediate medical attention.
Prescribing during pregnancy
The drug "Lospirin" during pregnancy can be prescribed only by the attending physician in case of emergency. In the course of clinical studies, it was found that the suppression of prostaglandin synthesis does not have a negative effect on the fetal development and the course of pregnancy in general. At the same time, acetylsalicylic acid cannot be prescribed in the first trimester, when the basic systems of the fetus are laid.
In the final trimester of pregnancy, prostaglandin synthesis inhibitors can cause cardiopulmonary toxicity and affect kidney function. Acetylsalicylic acid is not prescribed in the last stages of gestation, in order to avoid prolonged bleeding caused by antiplatelet action. There is also a risk of worsening contractile activity of the uterus, which lengthens the delivery process.
If treatment is necessary, the drug is prescribed in a minimum dose and for a short course of therapy.
Special instructions regarding the use of the drug
With caution, you should take "Lospirin 75" to individuals with increased sensitivity to anti-inflammatory and analgesic substances. Acetylsalicylic acid can affect the functionality of the kidneys if the patient has a history of ailments such as renal failure or vascular disease.
Patients with a tendency to allergic reactions should take tablets with extreme caution. The active ingredient is able to cause bronchospasm, urticaria, itching of the skin.
Even small doses of the drug can affect the rate of uric acid excretion, which is dangerous for patients with a diagnosis such as gout. The inhibitory effect of the main substance on platelet aggregation persists for several days. Therefore, it is recommended to stop taking the medicine before planned surgical interventions (including before tooth extraction) at least 5 days in order to prevent the development of bleeding.
In the presence of peptic ulcer, tablets based on acetylsalicylic acid can be prescribed only by your doctor.
Contraindications
The medication "Lospirin" is forbidden to use the instructions for use if the patient has intolerance or hypersensitivity to the components in the composition. Tablets cannot be used to treat patients with thrombocytopenia, hemorrhagic diathesis, hemophilia. Contraindication is also an ulcerative pathology of the gastrointestinal tract in the acute stage, renal and hepatic insufficiency, age under 16 years, bronchial asthma.
Interaction with other drugs
It is forbidden to take acetylsalicylic acid (Lospirin tablets) and methotrexate at the same time if the weekly dose of the latter exceeds 15 mg. The simultaneous administration of Lospirin and anticoagulants, thrombolytics should be avoided. This significantly increases the risk of bleeding.
It is undesirable to use simultaneously high doses of the drug with non-steroidal anti-inflammatory drugs to prevent the development of peptic ulcer of the digestive system and bleeding of the gastrointestinal tract.
The simultaneous use of the drug with digoxin helps to increase the concentration of the latter in blood serum. The hypoglycemic effect of drugs from the group of sulfonylurea derivatives used for treatment of diabetes is enhanced.
It is not recommended to take valproic acid with the drug "Lospirin" in order to avoid an increase in the toxic effect of acetylsalicylic acid on the body.
Alcohol interaction
The drug "Lospirin" instruction prohibits combining with alcohol. The components reinforce each other, which is a double blow to the mucous membrane of the digestive tract. In the presence of ulcerative lesion, it is quite possible to develop bleeding, which poses a serious danger to the patient's life.
Aspirin-based drugs can be taken no earlier than 12 hours after taking alcoholic beverages. Otherwise, negative consequences for the body are possible.
Symptoms of a drug overdose
An overdose of the drug is most often found in the elderly. The main signs of a pathological condition are:
- Dizziness.
- Attacks of nausea and vomiting.
- Confusion.
- Noise in ears.
- Acute intoxication.
- Hemorrhage.
- Respiratory failure.
- Hearing loss.
- Hypoglycemia.
The toxic effect of the main substance develops as a result of prolonged therapy or in excess of the recommended daily dosage. Moderate intoxication is observed against the background of repeated intake of elevated doses of the drug. If in the blood plasma the concentration of salicylates exceeds 300 μg / ml, there is a likelihood of acute intoxication, expressed in a change in acid-base balance.
A patient with symptoms of an overdose should be sent to a medical institution as soon as possible, where they will cleanse the body and restore the acid-base and electrolyte balance.
Side effects
The greatest number of negative consequences of taking the tablets is observed from the gastrointestinal tract. Perhaps the appearance of pain in the epigastric region, diarrhea, nausea, erosion and ulcerative lesions of the mucosa.
From the vascular system, there is a risk of bleeding from the nasal passages, gums, and digestive tract organs. Patients at risk for cerebral hemorrhage with arterial hypertension are most at risk. Some patients report the occurrence of headache, tinnitus and spatial orientation after taking Lospirin.
Instructions for use warns of possible negative reactions from the immune system. With increased sensitivity to the components, a skin reaction may appear in the form of urticaria, redness, itching.
Lospirin: price and reviews
Most patients taking the drug are satisfied with the result and the mild therapeutic effect. Unlike analogues, its dose is slightly lower, which reduces the risk of side effects, such as tinnitus, dizziness. It is also worth noting the relative safety of the drug "Lospirin." Patient reviews confirm that, thanks to the protective shell, there is practically no negative effect on the organs and mucous surface of the digestive system. The medicine begins to dissolve only in the intestine.
"Lospirin", the price of which ranges from 90 to 170 rubles. for 30 tablets, slightly more affordable than other antithrombotic drugs. The medicine has established itself as a prophylaxis of blood clots, the development of cerebral stroke and myocardial infarction. Using "Lospirin" as prescribed by a specialist and adhering to individual recommendations regarding treatment, negative consequences and side effects can be avoided.
How to replace?
The pharmaceutical market offers a huge selection of drugs with similar effects. The medicinal medication “Lospirin” analogues has the following:
- Aspirin Cardio is the most popular blood thinner and blood clot prevention product. It can be used for a long time.
- “Aspecard” is an anti-inflammatory, analgesic and antipyretic drug. It is used as an antithrombotic medicine.
- “Clopidogrel” is a synthetic antiplatelet drug used for the prevention of cardiovascular pathologies. The main active ingredient is clopidogrel bisulfate.