What is a medicine like Gepadif? Instructions for use, reviews on the effectiveness of this drug will be discussed below. Also, from the presented article, you will learn about why the tool in question is shown, in what form it is released, what it contains, etc.
Composition, dosage forms of the drug
Currently, this medication is produced in the following forms:
- A powder intended for the preparation of an infusion solution, which is placed in bottles and packs of cardboard, respectively.
The composition of this agent includes carnitine orotate, carnitine hydrochloride, antitoxic fraction, adenosine, pyridoxine hydrochloride and cyanocobalamin.
- The drug "Hepadif" - capsules. The instruction for use states that this form of the drug is available in a dark brown case with the inscriptions Hepadif and HSD. Their contents are finely divided powder of light yellow color with a brown tint. Gelatin capsules go on sale in contour cells and cardboard boxes, respectively. The composition of the medication under consideration includes: carnitine orotate, antitoxic fraction, pyridoxine hydrochloride, cyanocobalamin, adenine hydrochloride and riboflavin. It should also be noted that this tool contains the following auxiliary substances: black iron oxide , anhydrous lactose, red iron oxide, magnesium stearate, gelatin, yellow iron oxide, anhydrous colloidal silicon dioxide, titanium dioxide and microcrystalline cellulose.
Pharmacology of a medical product
What is the medicine in question? What does the instructions for use say about this? Hepadif is a combination drug. The mechanism of its action is due to the influence of the constituent components.
The drug is able to stimulate biosynthetic processes in the body and lipid metabolism, prevent hepatocyte necrosis, normalize hepatocyte proliferation, restore normal liver function, as well as the production of specific enzymes.
Features of the drug
What are the properties of the drug "Gepadif"? Instructions for use states that the adenosine contained in the drug is part of nucleic acids, coenzymes and almost all cells of the body. Moreover, it is an endogenous nucleoside and is able to regulate blood formation processes. This component reduces the tone of the smooth muscle walls of blood vessels, and also normalizes the supply of O2 hepatocytes.
What role do vitamins of group B (pyridoxine, riboflavin, cyanocobalamin) play in this medication? Owing to their presence, the Hepadif preparation takes an active part in the synthesis of the most important amino acids (tryptophan, methionine, cysteine, and others) and OVR. They also stimulate erythropoiesis and normalize fat, protein and carbohydrate metabolism.
The antitoxic fraction, which is part of the drug, contains interchangeable and irreplaceable amino acids, so it has an antioxidant and detoxifying effect.
As for carnitine, this component is directly involved in the breakdown of fatty acids, the regulation of fat metabolism and the normal absorption of food. It should be noted that this substance is able to stimulate the production of bile, increase the sensitivity of cells to insulin and facilitate the absorption of carbohydrates in the intestine, which are essential to support its normal flora.
Kinetic indicators
How is the absorption of the drug “Hepadif”? The use of the drug orally promotes the release of a complex of active components in the duodenum 12. After this, there is instant absorption of carnitine, vitamins, antitoxic fraction and adenine along the entire length of the small intestine.
The distribution of these substances is carried out not only in the intestine, but also in the liver and kidneys. The maximum concentration of riboflavin is observed in myocardial cells.
Pyridoxine metabolism is carried out in the liver. This component is distributed in the liver, as well as in muscle tissue and the nervous system. The products of metabolism are excreted mainly by the kidneys.
When a drug is administered intravenously, its substances are also distributed in muscle tissue, liver, brain, kidneys and cardiomyocytes. The metabolism of the solution also occurs in the liver, and metabolic products are excreted through the kidneys.
Indications for taking capsules and using powder
Under what conditions is the patient prescribed the medication in question? What does the instructions for use say about this? "Hepadif" is indicated for the complex treatment of the following diseases:
- cirrhosis of the liver;
- acute and chronic hepatitis;
- fatty liver disease;
- alcoholic liver damage;
- exogenous poisoning;
- intoxication, which was caused by the long-term use of antitumor and anti-tuberculosis drugs.
Contraindications
When should you not use Gepadif solution and capsules (tablets)? The instruction for use reports that these funds are contraindicated in:
- allergies to the components of the drug;
- erythema, nephrolithiasis, erythrocytosis and thromboembolism;
- under the age of 7 years;
- gastrointestinal ulcer (especially in the acute stage).
Instructions for use
"Gepadif" in the form of capsules is taken orally, washed down with water (whole). The dosage regimen of this agent, as well as the duration of treatment, is determined only by the attending physician.
Usually the daily dosage of the drug for adults is two capsules three times a day. As for babies from 7 years old, they are prescribed three tablets per day (in 3 divided doses).
In the event that the patient has difficulty using the whole capsule, its contents are allowed to be dissolved in a small amount of water or juice (only not in milk).
It should also be noted that if it is not possible to use the capsules, the patient is prescribed intravenous administration of the drug.
How to make injections with the drug "Gepadif"?
The instruction reports that the daily dosage of the solution for adults is 8.625 mg per kilogram of weight. The frequency of administration of this agent is 1 time per day.
Before injection, the contents of the vial are dissolved with a five percent glucose solution in a volume of 500 ml.
Dose adjustment for the elderly is not required.
Side effects
What adverse reactions does the medication in question cause? What does the instructions for use say about this? "Gepadif" is tolerated by patients quite well. Although in some cases they may still manifest the following side effects: indigestion, headache, nausea, constipation, urticaria, yellow staining of urine, vomiting, Quincke's edema, diarrhea, rashes on the skin.
Cases of drug overdose
In case of an overdose of this medication, the patient has: peripheral neuropathy, diarrhea, increased adverse reactions, vomiting.
To treat such conditions, the victim is prescribed gastric lavage and symptomatic therapy, as well as activated charcoal and saline laxatives.
Interaction
How does Gepadif interact with other drugs? The instruction says that before taking this medication, you should definitely consult a doctor.
"Riboflavin" is forbidden to combine with "Streptomycin", since the former significantly reduces the effectiveness of antibacterial drugs. Also, the metabolism of the drug in question, including its effect on the heart, is reduced by tricyclic antidepressants.
Vitamin B6, which is part of Gepadif, weakens the effect of Levodopa and reduces the manifestations of adverse reactions of anti-TB drugs and Isoniazid.
The absorption of vitamin B12 is influenced by alcohol, calcium preparations, paraaminosalicylic acid and Cimetitidine.
Reviews and analogues
There are many different analogues of "Gepadif." They may differ not only in price, but also in composition. These drugs include the following: Tavamin, Octamine Plus, Heptor, Karnitin, Elkar, Karnivit, Almiba, Karnigel, Karniten, Le Karnit, Aghvantar ”,“ Stimol ”,“ Heptral ”,“ Stateel ”.
As mentioned above, the medication in question has a wide spectrum of action. Therefore, it is prescribed for various diseases. However, most often this tool is used as part of complex therapy to support the liver.
Consumer opinions about the efficacy and effectiveness of this medicine are divided. This is due to the fact that the result of therapy with this agent may be different, depending on the degree of organ damage, the type of disease and the concomitant treatment with other medicines. Therefore, only a specialist should prescribe this drug after a thorough examination of the patient.
It should also be noted that many patients complain that when taking Gepadif they often have adverse reactions in the form of problems with stools and nausea.