What is the drug Tizalud? Instructions for use, reviews and features of this medication will be discussed below. You will also learn about whether the drug in question has side effects and prohibitions on its use.
Form, drug packaging, composition
In what form is the drug Tizalud released? Patient reviews report that this medication is sold in tablet form, which may include 4 or 2 mg of an active ingredient such as tizanidine.
In addition to the substance mentioned, the composition of the drug under consideration includes such additional elements as anhydrous lactose, sodium carboxymethyl starch, magnesium stearate and microcrystalline cellulose.
Tizalud tablets, reviews of which are presented below, are packed in contour cells that are placed in cardboard boxes.
Pharmacology of the oral agent
What is remarkable for such a drug as Tizalud? Instructions, reviews of specialists indicate that this tool is a muscle relaxant, showing a central effect.
What changes occur in the human body after taking the medication in question? The action of its active component on alpha2-adrenergic receptors (presynaptic) contributes to the inhibition of the excretion of excitatory amino acids from intermediate spinal neurons, which ultimately leads to a delayed polysynaptic pulse propagation in the spinal cord. Thanks to this mechanism of action, the tone of the patient’s muscle tissue is significantly reduced.
Drug features
What other properties are characteristic for the drug "Tizalud"? Reviews claim that, in addition to the muscle relaxant effect, tizanidine has a moderate analgesic effect.
According to the instructions, such tablets are very effective for chronic spasms of spinal and cerebral origin, as well as painful and acute spasms of muscle tissue.
Taking this medication significantly reduces muscle spasticity and clonic convulsions, resulting in reduced resistance to passive movements, as well as increased likelihood of active action.
Indications for taking the medication
Under what conditions of the patient is a drug such as Tizalud most effective? Reviews about the drug indicate that this medication quite well and quickly eliminates muscle cramps that are observed in pathologies of the spinal column and are accompanied by pain. Thus, the drug in question is often prescribed for:
- spondylosis;
- hemiplegia;
- osteochondrosis;
- syringomyelia;
- lumbar and cervical syndromes.
Are there any other indications for Tizalud? Reviews of experts say that this tool is actively used in the postoperative time after intervention for intervertebral hernias and osteoarthritis of the femoral joint. Also, the pills in question are good for pain and muscle spasticity provoked by neurological diseases, including chronic myelopathy, cerebral palsy, degenerative changes in the spinal cord, central seizures, cerebrovascular accident, multiple sclerosis, stroke, cranial and brain injuries.
Prohibitions on the use of oral medication
What contraindications should patients be aware of before taking Tizalud tablets? Instructions, reviews report that there are not many prohibitions on the use of this medicine. These include only the following conditions:
- hypersensitivity of the patient to tizanidine, as well as other components of the drug;
- concurrent administration of drugs such as Ciprofloxacin and Fluvoxamine, as well as other potent inhibitors of the CYP1A2 isoenzyme.
- liver pathology (severely leaking);
- the period of gestation;
- minor age;
- period of breastfeeding.
Cautious prescription of the drug
With caution, the medication in question should be prescribed in the following cases:
- with renal failure;
- at the age of more than 65-68 years;
- with bradycardia;
- with arterial hypotension;
- when combined with oral contraceptives.
The drug "Tizalud" (tablets): instructions for use
Reviews of doctors report that you should take this medication only after an individual consultation with a specialist.
Tizalud tablets are taken orally (orally), washed down with plain water, regardless of the meal.
The dosage of this medicine depends on the type and course of the disease. According to the instructions, for neurological pathologies that cause a painful (spastic) contraction of muscle tissue, treatment is recommended to start with a daily dose of 6 mg, which is divided into three doses. Depending on the nature of the spasm and pain, the next 3-7 days, this amount of the drug can be increased by 2-4 mg.
As medical practice shows, the maximum therapeutic effect is observed when taking a daily dose of 12-24 mg. At the same time, 36 mg is the maximum allowable daily dosage.
To stop painful skeletal muscle spasms, Tizalud tablets, reviews of which are ambiguous, are prescribed 3–4 mg three times a day. In especially severe cases, doctors recommend an additional medication at night in the same amount (i.e. 2-4 mg).
The duration of use of the drug “Tizalud” depends on the dynamics of muscle-tonic and pain manifestations. As a rule, acute muscle pain requires careful treatment for 8-20 days. In chronic pain syndrome, depending on the severity and origin, the patient may need to conduct longer therapy, which is determined individually (may last for one year).
Adverse reactions
Unfortunately, taking the medication in question can cause many negative reactions from the central nervous system, digestive tract, cardiovascular and respiratory systems, and others. Among the most frequently occurring side effects are the following:
- nausea, hepatitis, dizziness, dyspepsia;
- drowsiness, bradycardia, hallucinations;
- liver failure, sleep disturbances, dry mouth;
- insomnia, increased liver transaminase activity, muscle weakness, decreased blood pressure;
- fatigue, hypercreatininemia.
It should be noted that the abrupt cancellation of the drug Tizalud, especially after combining it with antihypertensive drugs and prolonged treatment or taking large dosages, can quite easily lead to the development of tachycardia, increased blood pressure, and in some cases to acute disturbance of cerebral circulation .
Overdose of tablets "Tizalud"
With a rather gross and regular violation of the dosage regimen, as well as when taking elevated doses of the drug in question, the patient has the following conditions: drowsiness, nausea, turning into vomiting, dizziness, hypotension, anxiety, miosis, coma, respiratory failure.
With these symptoms, the patient requires immediate gastric lavage, as well as an intestinal cleansing with an enema. In addition, the victim is shown taking sorbents, diuresis (forced) and further symptomatic therapy.
Interaction with other medicines
What medicines are forbidden to take the drug "Tizalud"? The parallel use of this medication with Fluvoxamine, Ciprofloxacin and other potent inhibitors of the CYP1A2 isoenzyme (including Amiodarone, Mexiletine, Propafenone, Cimetidine, Norfloxacin, Enoxacin, Pefloxacin, Pefloxacin ”,“ Rofecoxib ”and oral contraceptives) is not allowed.
Antihypertensive drugs significantly increase the risk of lowering the patient's blood pressure and the development of bradycardia.
Ethanol and sedatives can enhance the sleeping pills of tizanidine.
Special information
During prolonged therapy with the Tizalud drug, doctors need to monitor the patient’s liver at least once a month (preferably during the first four months of treatment).
Due to the threat of a “withdrawal syndrome” in case of refusal of treatment, the dose of tizanidine should be gradually reduced.
It is better to refuse Tizalud tablets if the patient's professional activities are related to driving vehicles and carrying out dangerous or accurate work.
Cost, analogues
The cost of the drug in Russian pharmacies is about 130-175 rubles (for 30 tablets, 2 mg and 4 mg). If required, then this medication can be replaced by such means as Tolperil, Lyorezal, Midokalm, Baklosan, Tolperizon and others.
The drug "Tizalud": reviews of doctors
Reviews of experts about the tool in question are very controversial. The negative reports of doctors very often refer to adverse reactions to the drug, which occur in patients almost immediately after the first dose. At the same time, experts argue that the most common negative effects are the following: lowering blood pressure, dizziness, weakness, lethargy, and drowsiness.
According to doctors, such phenomena are possible only when taking large doses of the drug, as well as if the patient has any contraindications. In this regard, some experts recommend starting therapy with half or even ¼ of the recommended dose. In the future, with normal tolerance of the medication, you can safely switch to the use of the full dosage.
As for the positive reviews, most doctors note the high effectiveness of the drug in question, as well as its quick action.