Is the Microzym drug effective - a medicine whose patient reviews you can find in the materials of this article? Today we will talk about it. Also, from the material you will surely learn about what diseases such a medication is prescribed for, how much it costs, whether it has side effects, analogues and contraindications.
Composition, form
What substances does “Microzyme" (medicine) include in its composition? Reviews of experts indicate that pancreatin is the active element of this drug. As excipients, this tool contains eudragit, triethyl citrate, simethicone, talc, gelatin, water, sodium lauryl sulfate, methyl parahydroxybenzoate, dyes and propyl paraben.
In what form can you get enzyme preparations of this type? "Mikrazim" goes on sale in the form of capsules. They have a transparent case and a brown lid. Inside, they contain cylindrical or spherical pellets of light brown or brown color. In this case, the granules of the drug have a characteristic odor.
For treatment, capsules of 10,000 units and 25,000 units may be recommended.
Pharmacological action of the enzyme preparation
What properties does the medication in question have? It is a tool that belongs to the latest generation of enzyme preparations. It contains such an active ingredient as pancreatin. This is an enzyme that is actively involved in digestion.
As you know, the composition of pancreatin includes substances such as lipase, amylase and protease. They are pancreatic enzymes and contribute to the absorption of fats, carbohydrates and proteins.
Gelatin capsules contain pancreatin granules that resemble mini-microspheres that are resistant to gastric juice. This effect is ensured by a special coating.
Thus, enzyme preparations of this type are directly involved in digestion, passing through the intestines. However, they have no effect on the stomach.
Pharmacokinetic features
After what time does Microzym (medicine) begin to act? Reviews of experts suggest that enzymes begin to be released in the small intestine. After that, they contribute to the digestion of food, as well as the normalization of digestive processes.
After taking the capsule inside, it dissolves in the stomach for several minutes, and then enters the intestines, where the mini-microspheres are released. The effect of the drug occurs after about 40 minutes. However, only its local effect is noted. In the intestines, the medicine is not absorbed. The output of the substance is carried out with feces.
Indications for use
The drug "Microzyme" is recommended to be taken in the following cases:
- For symptomatic treatment of digestive disorders (for example, with gastritis with low acidity, occurring in a chronic form, functional dyspepsia, liver and biliary tract diseases, diseases of the small or large intestine, in the presence of which their evacuation function is impaired, and also after partial removal of the intestine, gall bladder or stomach).
- As a replacement treatment for people with pancreatic insufficiency (for example, with cystic fibrosis, chronic inflammation of the pancreas, tumors of the pancreas, as well as after its removal).
- With comprehensive preparation for x-ray or ultrasound of the abdominal cavity.
- To ensure the digestion of food during normal functioning of the digestive tract (for example, when overeating, eating very fatty and high-calorie foods, violation of chewing, prolonged immobilization, etc.).
Contraindications
Under what conditions can you not take "Microzyme" (medicine)? Doctors' reviews indicate the following prohibitions:
- intolerance of the patient to pancreatin or its components;
- exacerbation of chronic changes in the pancreas;
- inflammation in the pancreas, especially in acute form.
The drug "Microzyme": instructions
According to the instructions attached to the drug, 10,000 units of pancreatin must be taken after eating or in the process of eating. In this case, it is advisable to drink the medicine with a large amount of liquid. The capsule is not recommended to chew or separate. If the patient cannot take it in its entirety, then its contents must be mixed with water or food. The resulting mixture must be swallowed without chewing.
Young patients under 4 years old with a diagnosis of cystic fibrosis are shown to receive 1000 units of lipase per kilogram of body weight. After the age of four, babies should receive about 500 units of lipase per kilogram of weight. The maximum allowable dosage is 10,000 units / kg per day.
With steatorrhea and diarrhea, it is recommended to take 25,000 units of the drug at each meal. The maximum permissible dose is 35,000 units.
Overdose Signs
What symptoms occur when taking high doses of the drug "Microzyme"? The analogue of this drug and the medication itself can cause quite severe constipation, as well as hyperuricemia and hyperuricosuria. With such signs, it is necessary to cancel the treatment, as well as consume a lot of fluids and conduct symptomatic therapy.
Side effects
In most cases, the drug "Microzym" is tolerated by patients quite well. However, in rare cases, it can cause some side effects. In this case, the medication should be canceled or its dosage adjusted.
Most often, the following side effects occur in patients:
- constipation;
- skin allergy (rash, urticaria);
- diarrhea;
- nausea and vomiting;
- epigastric discomfort;
- increased uric acid in blood and urine tests.
Cases of narrowing of the intestinal lumen in patients diagnosed with cystic fibrosis have also been reported.
Drug interaction
When combining the drug "Microzyme" with other medicines, it should be borne in mind that the absorption of iron and folic acid may decrease against its background. The bioavailability of the drug is reduced if it is simultaneously taken with antacids that contain magnesium hydroxide or calcium carbonate.
special instructions
With prolonged admission, the patient's health should be clearly monitored.
There is a decrease in the pharmacological effectiveness of the drug with helminthic infestations, dysbiosis, duodenostasis and acidification of the intestinal contents. Also, the effectiveness of the medication decreases if it is taken after the expiration date.
If you store the drug at high temperature, then the activity of its mini-microspheres decreases quite quickly.
The person’s ability to concentrate, drive a car or work with complex mechanisms does not affect the drug.
During therapy, capsules should be washed down with plenty of fluids. However, alkaline water is not recommended.
The medicine "Microzyme": price, analogues
The following agents are analogues of the drug for the active substance: Licrease, Pancrenorm, Gastenorm, Pancreal, Creon, Panzinorm, Enzistal, Pancreatin, Pancrelipase, Panzim and others . But you can replace the prescribed medication with a generic only after consulting with your doctor.
The cost of the drug is not very high. On average, the price for 20 capsules is 150-400 rubles and depends on the dosage.
Pregnancy, childhood, breastfeeding
For the treatment of children, only pediatricians prescribe the drug. During pregnancy and during breastfeeding, a medication can be taken only if the benefit from it exceeds the likely risk.
It should also be noted that to date there is no data on the penetration of pancreatin into breast milk.
Enzyme drug patient reviews
Most reviews about the drug "Microzyme" are positive. Patients observe a noticeable improvement in their condition with regular use of this medication with meals. At the same time, they note that it not only helps with diseases of the digestive system and pancreas, but also allows you to overcome all the unpleasant symptoms that arise when you overeat.
However, the reviews of doctors indicate that this medicine should be taken only according to indications. Otherwise, its uncontrolled intake may not give the expected effect.