The drug "Glutargin" refers to hepatoprotective drugs whose action is aimed at normalizing metabolic processes in liver cells by eliminating toxic substances from them and stabilizing the state of cell membranes. The use of this drug is associated with many features of the patient’s body and its current state. We will talk about this and much more in the article.
Composition and form of release
The active substance of the drug is glutamate arginine. In all pharmaceutical forms, this substance is contained in different concentrations. Among the dosage forms of the drug "Glutargin" instructions for use mention the following:
- powder for self-preparation of a solution intended for oral administration, with an arginine glutamate content of 1 g per serving;
- tablets for oral administration with the amount of active substance 0.25, 0.75 and 1 g;
- composition for the preparation of infusion solutions (concentrated) with an arginine glutamate content of 0.4 g per 1 ml;
- ready-made solution in ampoules with an active substance concentration of 0.04 mg per 1 ml.
Powders for the preparation of the drink are packed in plastic bags of 2 or 10 pieces in a cardboard box, along with them there is an instruction for use. Tablets are placed in blister packs of 2 or 10 pieces, 1, 2, 3, 5 or 10 blisters in a cardboard box (also with instructions in the kit). The concentrate and the finished solution are poured into glass ampoules. Those, in turn, are placed in plastic cuvettes of 5 pieces each. One cardboard box may contain 1 or 2 cuvettes, instructions for use of the drug and scarifiers for opening ampoules.
Vacation and storage conditions
The drug "Glutargin" instructions for use refers to over-the-counter medicines. To purchase this medication, you do not need to take a special prescription from the attending physician, but this does not mean that all patients, without exception, can take it.
It is necessary to store the medicine in rooms in which direct sunlight does not penetrate, at a temperature of no higher than 25 degrees. The shelf life of the drug is 2 years from the date of release. After this time, tablets, solution or powder “Glutargin”, the instructions for use recommends disposing of with household waste.
The properties
The pharmacological effect of the drug is based on its ability to quickly bind and remove ammonia from the body. The harmful substance is converted into a non-toxic form - glutamine, which is removed from the central nervous system in a natural way. In this case, the active component of the drug normalizes the state of cell membranes, thereby activating the body's natural defense processes. Arginine glutamate also has antioxidant effectiveness, which allows it to protect body cells from damage by free radicals.
The ability of arginine glutamate to positively affect the energy supply of liver cells allows the drug to be used for alcohol intoxication. This property is based on the stimulation of ethanol metabolism by blocking the inhibition of the corresponding enzymes. At the same time, arginine glutamate increases the amount of succinic acid synthesized in the body and stimulates the neurotransmitter centers of the central nervous system.
Indications for use
The drug "Glutargin", the instructions for use are recommended for patients suffering from the following diseases and disorders of the body:
- Liver diseases, including acute or chronic hepatitis, cirrhosis, hepatic encephalopathy (alcoholic or otherwise).
- Leptospirosis, accompanied by damage to the liver tissue.
- Hyperammonemia, in which the patient is in a state of coma or precoma.
- Poisoning with toxic substances, including poisonous toadstool poison , drugs, chemicals and alcohol.
- Withdrawal syndrome and / or post-toxicity caused by prolonged intake of alcohol.
Take "Glutargin" (tablets), the instruction for use recommends as a prophylactic before drinking alcoholic beverages. This helps to avoid intoxication of the body and quickly restore its normal functioning.
Contraindications
Despite the fact that the drug contains only one active component, its use is contraindicated in many diseases or organ malfunctions. So, the Glutargin preparation instruction (reviews of doctors confirm this fully) does not recommend taking phenylketonuria with any form and hypersensitivity to the main and / or any auxiliary substance. Do not use any medicinal form of the drug for therapeutic purposes for persons with severe impaired functioning of the urinary system and kidneys in particular.
The list of contraindications for the use of dosage forms of the drug “Glutargin” instructions for use (doctors' reviews - direct confirmation of this) includes pregnancy and the period of breastfeeding, as well as the patient's age under 18 years.
With extreme caution, this drug should be prescribed to patients with pronounced excitability and with a febrile state. Organic or physiological changes in the functions of the urinary system, which caused the inability of the kidneys to excrete nitrogen-containing metabolites, should also raise concerns about taking the medicine. As a rule, if therapy with this drug is necessary, the patient remains under round-the-clock supervision of medical staff.
How to take the drug "Glutargin"
Let's move on to the main issue - the rules for taking the drug, depending on its dosage form. The medicine "Glutargin" (tablets), the instruction advises to take 750 mg three times a day. Based on the patient’s condition, the attending physician can increase the dosage, which in any case should not exceed 2 g per dose. Tablets should be washed down with a sufficient amount of water (about 100 ml).
Powder, better known as "Glutargin 4", the instructions for use recommends using in the form of a solution. For this, it is necessary to dilute the contents of one packet in 75 ml of water immediately before administration. In acute alcohol intoxication, the solution is taken four times a day on the first day, the next 2-3 days - one serving of the drink twice a day. As a prophylactic, the Glutargin preparation (powder) is drunk in a double dose (2 packets per 1/2 glass of water) an hour before the meal.
Glutargin solution (ampoules) is recommended for use in acute alcohol poisoning. A drug prepared or prepared from a concentrate is administered intravenously twice daily by the drip method at the rate of 2 g of the drug per procedure. The rate of administration should not exceed 70 drops per minute. The course of treatment lasts at least five, but no more than 10 days. Upon completion of therapy, it is recommended to take Glutargin powder or tablets (no more than 1 g per day) for 20 days.
Adverse Reactions and Overdose
Among the adverse reactions during treatment with the drug, patients and doctors in their reviews call such phenomena as nausea and discomfort in the stomach. As a rule, unpleasant symptoms disappear on their own in a short time and do not require special medications.
If the norms recommended by the instruction are not observed, the Glutargin preparation can cause an overdose. Symptoms of it are a short decrease in blood pressure, lack of sleep, pain behind the sternum, nausea and the urge to vomit. Also, according to expert reviews, the patient may be disturbed by allergic reactions. Treatment for an overdose is symptomatic, in rare cases, the introduction of antihistamines and / or glucocorticosteroids is required.
Special instructions and compatibility with other drugs
All dosage forms of the Glutargin preparation do not affect the ability to drive vehicles and complex mechanisms. The drug does not affect vision and the speed of psychomotor reactions.
Particular attention when prescribing the maximum dosage is required by patients with impaired endocrine system: diabetes, acromegaly. Doctors say that the drug itself causes slight fluctuations in hormone levels, but in combination with the Aminophylline medication it can cause a surge in the content of endogenous insulin and growth hormone in the blood.
In addition, drugs containing arginine glutamate (including Glutargin Alcocline) do not recommend taking the drug together with Vinblastine and Dipyridamole, as they significantly reduce each other's effectiveness.
Analogues of the drug "Glutargin", prices
To date, the pharmaceutical market may present several analogues of the drug "Glutargin." Some instruction It belongs to the pharmacological group of hepatoprotectors of synthetic or natural origin: Karsil, Thiotriazolin, Dipana and Hepa-Merz. A complete analogue of the drug - “Glutargin Alcocline” - contains the same active substance, that is, arginine glutamate.
Compared with its analogues, the Glutargin preparation has a lower cost: about 75 rubles per 10 tablets with a dosage of 0.25 g and 100 rubles per package of the same 10 tablets containing 1 g each of arginine glutamate. Powder costs a little more - from 97 to 130 rubles for a package containing 10 bags. The most expensive dosage form is a solution in ampoules. One package of 10 ampoules of 5 ml each costs at least 1000 rubles.
Opinion about the drug
Reviews about the drug "Glutargin" a lot. Patients in most cases talk about a good effect of the drug. At the same time, they mention the appearance of some discomfort in the stomach (up to nausea). According to those who have repeatedly resorted to Glutargin medication, unpleasant symptoms quickly disappeared without taking any special drugs. In addition, consumers noted the availability of the drug, as it is inexpensive.