"Baklosan": patient reviews, instructions for use and composition

In the article, we consider the instructions for use, price and reviews of “Baklosan”.

It is a pharmacological drug that is part of the muscle relaxant group. Under its influence, the tension and tone of the striated muscles decreases. Use it to reduce the severity of muscle cramps and tension, as well as for muscle relaxation in a variety of pathologies of the structures of the central nervous system. Reviews about "Baklosan" are in large numbers.

Composition, release form

The drug "Baklosan" is produced by the manufacturer in a single pharmacological form - in tablets. Tablets can be in two dosages - 10 and 25 mg. The tablets have a biconvex shape, their color is white. The main active ingredient is baclofen. As additional components are used: ethyl cellulose, talc, magnesium stearate, gelatin, lactose, potato starch.

Tablets are packed in plastic bottles of 50 pieces. Each carton pack contains one bottle. Such packaging is due to long courses of use of the drug.

The price, reviews, analogues of "Baklosan" are of interest to many.

The properties

The main active component of the drug - the substance baclofen - is a derivative of gamma-aminobutyric acid. It is part of the pharmacological group of central muscle relaxants. Baclofen is able to exert muscle relaxant (relaxing striated muscles) and antispastic (eliminating muscle cramps) effects due to the following pharmacological effects:

1. It reduces the excitability of afferent (sensitive) nerve fibers located in the spinal cord and in the brain. As a result, the excitability of the NS decreases and its readiness for the formation of muscle cramps.
2. Reduces the preliminary tension of the fibers forming the striated muscles.
3. It inhibits the activity and functionality of the intermediate neurons responsible for the transmission of impulses to afferent nerve fibers.

Pharmacokinetics

The indicated pharmacological effects of the active component determine the ability of Baklosan to reduce muscle readiness for cramps, reduce contractile tension in them, and increase the volume of joint movement through muscle relaxation (muscle fiber relaxation). The drug does not have a direct effect on the transmission of impulses between nerves and muscles.

The therapeutic concentration in the blood occurs half an hour after taking the pill orally. The maximum concentration is reached after 2-3 hours. Baclofen has a high bioavailability, is able to penetrate the blood-brain barrier and accumulate in the tissues of the central nervous system. In addition, the active component is able to overcome the placental barrier and accumulate in the fetus during pregnancy. It is also excreted along with breast milk during lactation. Baclofen is metabolized in the tissues of the liver, unchanged substance, as well as its metabolites, are excreted by the kidneys, along with urine.

This confirms the instructions for the drug "Baklosan". Reviews about this drug are mostly positive.

Indications for admission

Baklosan tablets are used as part of the complex treatment of pathologies accompanied by an increased tone of various groups of striated muscles. Among these diseases:

1. Neoplasms of a benign or malignant nature, localized in the spinal cord or brain, to varying degrees affecting intermediate neurons and motor centers.
2. Multiple sclerosis, which is a chronic pathology of nerve fibers and CNS structures. It is always accompanied by the appearance of foci of increased nervous excitability.
3. Syringomyelia, accompanied by a violation of the process of formation of the membranes of the nerve fiber and a change in the process of conducting an impulse in them.
4. Pathologies of the brain or spinal cord having an infectious etymology.
5. Past injuries of the central nervous system - TBI open or closed type, damage to the brain or spinal cord.
6. A stroke of the brain that affects the motor centers.
7. Meningitis. It is a process of inflammation that occurs in the membranes of the brain and spinal cord, which affects the functionality of the structures of the central nervous system.
8. Cerebral palsy, which is a consequence of acute cerebral hypoxia transferred to the perinatal period. Often accompanied by the development of severe spasms of striated muscles.
9. Alcoholism in chronic form, accompanied by alcoholic toxic damage to a variety of structures that form the brain and spinal cord.

The need for taking the drug is determined individually by a neurologist, after an appropriate examination.

Reviews on the use of "Baklosan" consider below.

Contraindications

The use of the drug is strictly contraindicated if the patient has the following pathologies or physiological conditions:

1. Any gestational age, lactation. If there is an urgent need to take "Baklosan" during lactation, a woman should transfer the child to feed with adapted milk mixtures and only after that start taking the tablets.
2. Renal failure in chronic or acute form. In this condition, the rate of excretion of baclofen and its metabolites decreases sharply.
3. Parkinson's disease, in which there is a pronounced pathology of the transmission of impulses between the centers of the brain, as well as the spinal cord and motor structures.
4. Psychoses. Diseases in which the functional activity of the cerebral cortex is impaired. It is accompanied by the appearance of delusional thoughts, motor and speech agitation, hallucinations.
5. A history of seizures.
6. Epilepsy. It is a severe pathology of the central nervous system, in which attacks of tonic-clonic seizures develop.
7. Hypersensitivity and individual sensitivity to any component that is part of the drug.

“Baklosan” should be prescribed with extreme caution if the patient has cerebrovascular insufficiency (the intensity and volume of blood circulation in the brain decreases), gastrointestinal ulcers. And also if the patient is in old age or has not reached 12 years.

This is indicated in the instructions for use with "Baklosan." According to reviews, the price of the drug is quite reasonable.

Dosage

Baclosan tablets should be taken orally, as a whole, without crushing or chewing. Reception must be carried out after a meal, drink it with a large amount of liquid. The duration of use of the drug, as well as the required dosage, should be established by the doctor individually. The average dose of the drug depends on the age of the patient:

1. Children 12-24 months of age are shown to take no more than 10-20 mg daily.
2. Children 2-6 years old - several doses daily of 20-30 mg.
3. Children 6-10 years old are shown a dosage of 30-60 mg, which should be divided into several doses.
4. For children from 10 years old, the dosage is calculated according to the formula 2 mg / kg. Thus, the daily dosage is obtained, which must be divided into several doses.
5. Adult patients should start taking with a minimum dosage of 5 mg three times a day. After a few days, it must be increased in order to achieve therapeutic efficacy. On average, it is up to 75 mg. It is permissible to take no more than 100 mg of the substance per day.
6. For patients over 65 years of age, the dosage is calculated similarly to adult patients, but it is recommended to increase the therapeutic dose gradually, over a longer period. Throughout the course of treatment, laboratory indicators of liver and kidney function should be monitored.

The course of therapy is most often time-consuming. Its duration should be established individually by a neurologist, taking into account the general condition of the patient, his age and underlying pathology.

Side effects

According to reviews of Baklosan, against the background of its administration some undesirable effects from the side of different systems and organs may develop. Among them:

1. Violations of the stool, vomiting, dry mouth, nausea - from the gastrointestinal tract.
2. Arterial hypotension - from the CCC.
3. Of varying severity, cramps, hallucinations, ataxia, anxiety, depression, apathy and indifference, decreased mood, confusion, increased fatigue - from the central nervous system.
4. Tremor of the extremities, in particular, of the hands, muscle weakness, severe myalgia - from the musculoskeletal system.
5. Spasm of accommodation and nystagmus - from the eyes.
6. Enuresis, dysuria, acute urinary retention - from the urinary system. When using the drug for a very long time, kidney failure can develop.

If the patient develops any of these undesirable effects when taking Baklosan, it is recommended to stop using the drug and consult a neurologist for advice. This is confirmed by the Baklosan product instructions for use and reviews.

Special instructions for use

It is a potent drug. Before using them, it is imperative that you carefully study the annotation, exclude the presence of contraindications, familiarize yourself with specific instructions, including:

1. Patients who have liver pathologies should periodically monitor the activity of hepatic transaminases (markers of the destruction of liver cells) in plasma.
2. Baclofen is able to enhance the therapeutic effect of medications that affect the functionality of the central nervous system.
3. Baclofen enhances the effect of alcohol on the central nervous system.
4. Long-term use of the drug involves periodic laboratory monitoring of renal activity.
5. Against the background of taking “Baklosan”, the patient’s attention concentration and psychomotor speed are reduced.

The drug can be purchased in pharmacies only with a doctor’s prescription. Pills are prescribed by a doctor after a neurological examination. The dosage and duration of the course of therapy should be regulated by a doctor.

According to reviews, analogues of Baklosan are also very effective.

Overdose

In case of an overdose of a medication, the patient develops muscular hypotension, and the respiratory center of the medulla oblongata is inhibited. The risk of respiratory arrest increases. Significant overdose causes coma.

The specific antidote is currently unknown to medicine. If overdose symptoms are detected, bowel and stomach rinsing should be performed, symptomatic therapy should be prescribed to the patient.

Below we consider the price and reviews of Baklosan.

Cost, analogues

The average cost of a drug in a dosage of 10 mg is 250 rubles per bottle of 50 tablets. At a dosage of 25 mg - 450 rubles for the same number of tablets.

Among the analogues of "Baklosan" according to the active substance, rectal suppositories "Lyorezal", tablets "Baklofen" are distinguished.

Reviews about "Baklosan"

Reviews of the drug indicate that for many patients, “Baklosan” was really effective and at the same time affordable drug. Negative reviews also occur, and they are mainly associated with the development of adverse reactions while taking the medication.

There is information in the reviews about Baklosan that patients of drug treatment clinics take the drug in parallel with certain narcotic substances. This combination can cause trip and addiction. Rarely, patients note that withdrawal syndrome occurs even when using therapeutic doses of the drug. If this happened, then the abolition of the medication should be carried out gradually, over two to three weeks.

We reviewed the Baklosan tool, instructions, price and reviews.