The name of the medicine “Cefotaxime” absolutely coincides with its International Patent Name. The drug belongs to the clinical and pharmacological group of 3rd generation cephalosporins. Pronounced bactericidal action of the drug is due to the inhibitory effect of the drug on the bacterial cell wall . A wide range of action of the drug “Cefotaxime” is noted. Instructions for use indicate its high activity against a large group of gram-negative bacteria, some of which are resistant to other antibiotics.
Due to the fact that the drug is administered parenterally, the form of release of the drug “Cefotaxime” is the powder from which the solution for injection is made.
Good pharmacokinetic properties of the cefotaxime antibiotic are noted. Instructions for use indicate its fairly rapid distribution in the tissues of the body, especially high concentrations of the drug reaches in the cerebrospinal fluid. The drug is excreted completely during the day, its main part leaves the body with urine (up to 60%).
The drug "cefotaxime." Indications for use
Taking the medicine “Cefotaxime” is recommended for patients who have been diagnosed with infectious and inflammatory diseases caused by microorganisms sensitive to the medication. Such pathologies include, first of all, CNS infections, for example, meningitis. There is a high effectiveness of the drug in the treatment of ENT organs and respiratory tract infections.
The list of indications for use continues the following diseases:
- urinary tract infections;
- septicemia, bacteremia, peritonitis;
- Infectious lesions of the joints and bones of the body;
- soft tissue infections, including infection with burns.
As a prophylaxis of the occurrence of infections, the use of Cefotaxime is also recommended.
The use of the medicine after surgical interventions (operations on the digestive tract, urological, gynecological) helps to prevent complications associated with the accidental entry of pathogens into the wounds.
The drug "cefotaxime." Description of contraindications for use
A broad-spectrum antibiotic, which is Cefotaxime, in some cases can have an adverse effect on the patient's body. At the same time, they speak of contraindications to the use of this tool. To the list of cases when treatment with Cefotaxime is not recommended, the instructions for use include:
- children's age of the patient;
- particular sensitivity to the cefotaxime antibiotic. It is contraindicated in people who have a high sensitivity to penicillins, carbapenems, and other cephalosporins.
With caution, cefotaxime should be prescribed to newborns, patients with severe renal failure (chronic forms), with peptic ulcer.
If during the period of lactation there is a need for treatment with Cefotaxime, the instructions for use recommend that you stop breastfeeding the baby for this period.
To date, there is no information about medical observations regarding the administration of the drug “Cefotaxime” during pregnancy. Treatment can be considered justified if it is vital for a woman and prevails over the potential risk to the health of the fetus.
The drug "cefotaxime." Side effects
Taking the cefotaxime antibiotic can cause the patient some negative reactions that occur symptomatically from various body systems.
In the first place, the digestive system can negatively react, since Cefotaxime has a strong inhibitory effect on the intestinal microflora. Often in such cases, the patient is concerned about vomiting, nausea, diarrhea. A negative effect can manifest itself even in the form of cholestatic jaundice, hepatitis.
Often there are changes in the hematopoietic system, manifested in the form of thrombocytopenia, leukopenia, hemolytic anemia.
It reacts negatively to taking this antibiotic and central nervous system, in some cases dizziness is noted and headaches are disturbing. Rash, itching, Quincke's edema (rarely) are allergic reactions resulting from the use of the drug in treatment.
In medical practice, there are cases of negative effects of the active substance of the drug on the cardiovascular, urinary systems, as well as the manifestation of local reactions (pain at the site of intravenous administration).
There are no special instructions for storing the drug “Cefotaxime”, it is enough just to observe the expiration date indicated on its packaging and find a cool dark place, inaccessible to children.